KLB

Gene Name		klotho beta
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Fibroblast Growth Factor Receptor Binding Protein Binding Fibroblast Growth Factor Binding
	Biological Process	Carbohydrate Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway
Pathways		Signaling by the B Cell Receptor (BCR) Phospholipase C-mediated cascade Signaling by FGFR in disease SHC-mediated cascade Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade PI3K Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R PI3K events in ERBB2 signaling Downstream signaling of activated FGFR FGFR ligand binding and activation Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer betaKlotho-mediated ligand binding Signaling by FGFR Klotho-mediated ligand binding FRS2-mediated cascade IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade
Drugs
Diseases
GWAS
Protein-protein Interactions		1 interactors: FGF21
Entrez ID		152831
HPRD ID		14097
Ensembl ID		ENSG00000134962
Uniprot IDs		B4DYH5 Q86Z14
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Positive Regulation Of Receptor Biosynthetic Process Regulation Of Low-density Lipoprotein Particle Clearance Regulation Of Receptor Biosynthetic Process Positive Regulation Of Glucose Import Positive Regulation Of Glucose Transport Regulation Of Glucose Import Regulation Of Glucose Transport Positive Regulation Of ERK1 And ERK2 Cascade Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Response To Fibroblast Growth Factor
Tagcloud ?		5httlpr 7alpha ba cholesten colonic constipation ct48 fdr fecal fgf19 fgfr4 gpbar1 ibs insert irritable multifaceted pathobiological pathobiology predisposing reuptake rs11554825 rs17618244 rs351855 rs4263839 rs4795541 sensation slc6a4 tnfsf15 transit