PAPOLA

Gene Name		poly(A) polymerase alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Magnesium Ion Binding RNA Binding Polynucleotide Adenylyltransferase Activity ATP Binding Manganese Ion Binding
	Biological Process	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription RNA Splicing Gene Expression MRNA 3'-end Processing RNA Polyadenylation
Pathways		mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Processing of Capped Intronless Pre-mRNA mRNA Splicing - Major Pathway Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs mRNA 3'-end processing
Drugs
Diseases
GWAS
Protein-protein Interactions		6 interactors: CPSF1 CPSF3 RRAGA SMAD2 SNRPA YWHAE
Entrez ID		10914
HPRD ID		10407
Ensembl ID		ENSG00000090060
Uniprot IDs		G3XAH6 P51003
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Processing MRNA Cleavage MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Polyadenylation RNA Polyadenylation Termination Of RNA Polymerase II Transcription RNA Splicing Cellular Localization MRNA Processing MRNA Export From Nucleus DNA-templated Transcription, Termination RNA Export From Nucleus MRNA 3'-end Processing MRNA Metabolic Process RNA 3'-end Processing Nuclear Export MRNA Transport Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Negative Regulation Of Peptidyl-serine Dephosphorylation Regulation Of Heart Rate By Hormone RNA Transport RNA Localization Establishment Of Localization In Cell Zygotic Specification Of Dorsal/ventral Axis Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Transcription From RNA Polymerase II Promoter Positive Regulation Of Cytolysis Histone MRNA 3'-end Processing Negative Regulation Of Protein Dephosphorylation Positive Regulation Of Mesoderm Development Primary MiRNA Processing Regulation Of Nodal Signaling Pathway Common-partner SMAD Protein Phosphorylation Nucleocytoplasmic Transport Nuclear Transport Positive Regulation Of Activin Receptor Signaling Pathway Regulation Of Heart Rate By Chemical Signal Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Nucleic Acid Phosphodiester Bond Hydrolysis Positive Regulation Of Signal Transduction SMAD Protein Complex Assembly Membrane Repolarization Paraxial Mesoderm Morphogenesis RNA Metabolic Process Nodal Signaling Pathway Intracellular Transport Gene Expression Histone MRNA Metabolic Process
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