NRG3

Gene Name		neuregulin 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Integral Component Of Plasma Membrane
	Molecular Function	Receptor Binding Growth Factor Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Tyrosine Kinase Binding
	Biological Process	Regulation Of Cell Growth Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Pattern Specification Process Intracellular Signal Transduction Organ Development Mammary Placode Formation
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT SHC1 events in ERBB2 signaling Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation GRB2 events in ERBB2 signaling PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Nuclear signaling by ERBB4 SHC1 events in ERBB4 signaling Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS		Cardiac hypertrophy ( 21348951) Obesity-related traits ( 23251661) Response to iloperidone treatment (QT prolongation) ( 18521091) Retinopathy in non-diabetics ( 23393555)
Protein-protein Interactions		1 interactors: ERBB4
Entrez ID		10718
HPRD ID		16115
Ensembl ID		ENSG00000185737
Uniprot IDs		B3KVG8 B9EGV5 D9ZHP6 D9ZHP8 D9ZHP9 D9ZHQ2 D9ZHQ5 D9ZHQ6 D9ZHQ7 P56975
PDB IDs
Enriched GO Terms of Interacting Partners?		Cardiac Muscle Tissue Regeneration Central Nervous System Morphogenesis Positive Regulation Of STAT Protein Import Into Nucleus Mitochondrial Fragmentation Involved In Apoptotic Process Olfactory Bulb Interneuron Differentiation Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Mammary Gland Epithelial Cell Differentiation Mitochondrial Fission Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Heart Growth Olfactory Bulb Development Olfactory Lobe Development Mammary Gland Alveolus Development Mammary Gland Lobule Development Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Organ Growth Neural Crest Cell Migration Regulation Of Phosphatidylinositol 3-kinase Activity Tissue Regeneration Lactation Regulation Of Heart Growth Regulation Of Lipid Kinase Activity Regulation Of Cardiac Muscle Tissue Development Positive Regulation Of JAK-STAT Cascade Forebrain Neuron Differentiation Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Muscle Tissue Development Neural Crest Cell Development Apoptotic Mitochondrial Changes Forebrain Generation Of Neurons Neural Crest Cell Differentiation Embryonic Pattern Specification Regulation Of JAK-STAT Cascade Positive Regulation Of Protein Import Into Nucleus Mammary Gland Epithelium Development Regulation Of Organ Growth Body Fluid Secretion Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Mesenchymal Cell Development Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Striated Muscle Tissue Development Mesenchymal Cell Differentiation Phosphatidylinositol-mediated Signaling Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Developmental Growth Positive Regulation Of Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway
Tagcloud ?		190b 219a 28a addiction adhd amygdala bioinformatics biologically bot bxd compulsive coregulation determines genenetwork impu1 impulse impulsive impulsivity malfunction meaningful mirnas neuregulin outgrowth overrepresentation overrepresented plasticity psychiatric synaptic traits