| GPR161 |
G protein-coupled receptor 161 |
- Hedgehog 'off' state
- Hedgehog 'on' state
|
|
|
| KIFAP3 |
kinesin associated protein 3 |
- Translocation of SLC2A4 (GLUT4) to the plasma membrane
- MHC class II antigen presentation
- Intraflagellar transport
- COPI-dependent Golgi-to-ER retrograde traffic
- Kinesins
- Kinesins
|
|
|
| LMNA |
lamin A/C |
- XBP1(S) activates chaperone genes
- Signaling by BRAF and RAF fusions
|
|
- Restrictive dermopathy
- Emery-Dreifuss muscular dystrophy
- Dilated cardiomyopathy (DCM)
- Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
- Mandibuloacral dysplasia
- Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
- Limb-girdle muscular dystrophy (LGMD)
- Familial partial lipodystrophy (FPL), including the following four diseases: Kobberling-type lipodystrophy (FPLD1); Dunnigan-type lipodystrophy (FPLD2); Dunnigan-like lipodystrophy (FPLD3); AKT2 associated lipodystrophy
- Hutchinson-Gilford progeria syndrome
|
| LMNB1 |
lamin B1 |
- Meiotic synapsis
- Formation of Senescence-Associated Heterochromatin Foci (SAHF)
- Nuclear Envelope Breakdown
- Initiation of Nuclear Envelope (NE) Reformation
- Breakdown of the nuclear lamina
- Depolymerisation of the Nuclear Lamina
- Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
- Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
|
|
|
| PPP1CA |
protein phosphatase 1 catalytic subunit alpha |
- Triglyceride catabolism
- DARPP-32 events
- Downregulation of TGF-beta receptor signaling
- Circadian Clock
|
- 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
|
|
| PPP1CC |
protein phosphatase 1 catalytic subunit gamma |
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
- Triglyceride catabolism
- Downregulation of TGF-beta receptor signaling
- Separation of Sister Chromatids
- Resolution of Sister Chromatid Cohesion
- Circadian Clock
- RHO GTPases Activate Formins
- Mitotic Prometaphase
- EML4 and NUDC in mitotic spindle formation
|
- 9,10-Deepithio-9,10-Didehydroacanthifolicin
- Calyculin A
- Motuporin
|
|
| TERF2 |
telomeric repeat binding factor 2 |
- Recognition and association of DNA glycosylase with site containing an affected pyrimidine
- Cleavage of the damaged pyrimidine
- Recognition and association of DNA glycosylase with site containing an affected purine
- Recognition and association of DNA glycosylase with site containing an affected purine
- Cleavage of the damaged purine
- Cleavage of the damaged purine
- Meiotic synapsis
- Packaging Of Telomere Ends
- Telomere Extension By Telomerase
- DNA Damage/Telomere Stress Induced Senescence
|
|
|
| TERF2IP |
TERF2 interacting protein |
- Recognition and association of DNA glycosylase with site containing an affected pyrimidine
- Cleavage of the damaged pyrimidine
- Recognition and association of DNA glycosylase with site containing an affected purine
- Recognition and association of DNA glycosylase with site containing an affected purine
- Cleavage of the damaged purine
- Cleavage of the damaged purine
- Meiotic synapsis
- Packaging Of Telomere Ends
- Telomere Extension By Telomerase
- DNA Damage/Telomere Stress Induced Senescence
|
|
|