| BAIAP2 |
BAR/IMD domain containing adaptor protein 2 |
- Regulation of actin dynamics for phagocytic cup formation
- Regulation of actin dynamics for phagocytic cup formation
- VEGFA-VEGFR2 Pathway
- RHO GTPases Activate WASPs and WAVEs
- RHO GTPases Activate WASPs and WAVEs
- FCGR3A-mediated phagocytosis
- FCGR3A-mediated phagocytosis
|
|
|
| BCL2 |
BCL2 apoptosis regulator |
- Activation of BAD and translocation to mitochondria
- BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
- Interleukin-4 and Interleukin-13 signaling
- The NLRP1 inflammasome
- Estrogen-dependent gene expression
- Estrogen-dependent nuclear events downstream of ESR-membrane signaling
|
- Ibuprofen
- Paclitaxel
- Docetaxel
- Rasagiline
- S-8184
- Paclitaxel docosahexaenoic acid
- Glycine betaine
- Eribulin
- Dexibuprofen
- Venetoclax
- Obatoclax
- Navitoclax
|
- Choriocarcinoma
- Gastric cancer
- Chronic lymphocytic leukemia (CLL)
- Small cell lung cancer
- Kaposi's sarcoma
- Nasopharyngeal cancer
- Cervical cancer
|
| BCL2L1 |
BCL2 like 1 |
- BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
- Interleukin-4 and Interleukin-13 signaling
- The NLRP1 inflammasome
|
- 4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID
- Gossypol
|
|
| CERT1 |
ceramide transporter 1 |
|
|
|
| CGREF1 |
cell growth regulator with EF-hand domain 1 |
|
|
|
| CHMP6 |
charged multivesicular body protein 6 |
- Budding and maturation of HIV virion
- Macroautophagy
- Endosomal Sorting Complex Required For Transport (ESCRT)
- HCMV Late Events
- Late endosomal microautophagy
- Sealing of the nuclear envelope (NE) by ESCRT-III
|
|
|
| CLN8 |
CLN8 transmembrane ER and ERGIC protein |
|
|
- Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10)
- Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
|
| CNTNAP1 |
contactin associated protein 1 |
|
|
|
| CRMP1 |
collapsin response mediator protein 1 |
- CRMPs in Sema3A signaling
|
|
|
| FXR2 |
FMR1 autosomal homolog 2 |
|
|
|
| GLP1R |
glucagon like peptide 1 receptor |
- Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
- Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
- G alpha (s) signalling events
- Glucagon-type ligand receptors
- ADORA2B mediated anti-inflammatory cytokines production
|
- Glucagon recombinant
- Exenatide
- Liraglutide
- Albiglutide
- Dulaglutide
- Lixisenatide
- Semaglutide
|
|
| HLA-DPB1 |
major histocompatibility complex, class II, DP beta 1 |
- Downstream TCR signaling
- Phosphorylation of CD3 and TCR zeta chains
- Translocation of ZAP-70 to Immunological synapse
- Generation of second messenger molecules
- MHC class II antigen presentation
- PD-1 signaling
- Interferon gamma signaling
|
|
- Dilated cardiomyopathy (DCM)
|
| IPP |
intracisternal A particle-promoted polypeptide |
|
|
|
| LAMA4 |
laminin subunit alpha 4 |
- Laminin interactions
- Laminin interactions
- Non-integrin membrane-ECM interactions
- ECM proteoglycans
- MET activates PTK2 signaling
|
|
|
| LMNA |
lamin A/C |
- XBP1(S) activates chaperone genes
- Signaling by BRAF and RAF fusions
|
|
- Restrictive dermopathy
- Emery-Dreifuss muscular dystrophy
- Dilated cardiomyopathy (DCM)
- Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
- Mandibuloacral dysplasia
- Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
- Limb-girdle muscular dystrophy (LGMD)
- Familial partial lipodystrophy (FPL), including the following four diseases: Kobberling-type lipodystrophy (FPLD1); Dunnigan-type lipodystrophy (FPLD2); Dunnigan-like lipodystrophy (FPLD3); AKT2 associated lipodystrophy
- Hutchinson-Gilford progeria syndrome
|
| LRCH4 |
leucine rich repeats and calponin homology domain containing 4 |
|
|
|
| LRPAP1 |
LDL receptor related protein associated protein 1 |
|
|
|
| MBP |
myelin basic protein |
- EGR2 and SOX10-mediated initiation of Schwann cell myelination
|
|
|
| NAPA |
NSF attachment protein alpha |
- COPII-mediated vesicle transport
- Golgi Associated Vesicle Biogenesis
- COPI-mediated anterograde transport
- COPI-dependent Golgi-to-ER retrograde traffic
- Intra-Golgi traffic
- Retrograde transport at the Trans-Golgi-Network
|
|
|
| NR4A1 |
nuclear receptor subfamily 4 group A member 1 |
- AKT phosphorylates targets in the nucleus
- Nuclear Receptor transcription pathway
- Constitutive Signaling by AKT1 E17K in Cancer
|
|
|
| NRXN1 |
neurexin 1 |
- Neurexins and neuroligins
- Neurexins and neuroligins
- Non-integrin membrane-ECM interactions
- Neurexins and neuroligins
- Neurexins and neuroligins
|
- Calcium Citrate
- Calcium Phosphate
|
- Pitt-Hopkins syndrome, including: Pitt-Hopkins syndrome; Pitt-Hopkins-like syndrome
|
| NSD1 |
nuclear receptor binding SET domain protein 1 |
- PKMTs methylate histone lysines
|
|
- Beckwith-Wiedemann syndrome
- Sotos syndrome and Weaver syndrome
|
| PLEKHF2 |
pleckstrin homology and FYVE domain containing 2 |
|
|
|
| POT1 |
protection of telomeres 1 |
- Recognition and association of DNA glycosylase with site containing an affected pyrimidine
- Cleavage of the damaged pyrimidine
- Recognition and association of DNA glycosylase with site containing an affected purine
- Recognition and association of DNA glycosylase with site containing an affected purine
- Cleavage of the damaged purine
- Cleavage of the damaged purine
- Meiotic synapsis
- Packaging Of Telomere Ends
- Telomere Extension By Telomerase
- DNA Damage/Telomere Stress Induced Senescence
|
|
|
| PPP1R21 |
protein phosphatase 1 regulatory subunit 21 |
|
|
|
| PRR13 |
proline rich 13 |
|
|
|
| RAB33A |
RAB33A, member RAS oncogene family |
- TBC/RABGAPs
- RAB geranylgeranylation
|
|
|
| RPS27 |
ribosomal protein S27 |
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
- L13a-mediated translational silencing of Ceruloplasmin expression
- Peptide chain elongation
- SRP-dependent cotranslational protein targeting to membrane
- SRP-dependent cotranslational protein targeting to membrane
- Viral mRNA Translation
- Selenocysteine synthesis
- Separation of Sister Chromatids
- Resolution of Sister Chromatid Cohesion
- RHO GTPases Activate Formins
- Major pathway of rRNA processing in the nucleolus and cytosol
- Mitotic Prometaphase
- Translation initiation complex formation
- Formation of a pool of free 40S subunits
- Formation of the ternary complex, and subsequently, the 43S complex
- Ribosomal scanning and start codon recognition
- GTP hydrolysis and joining of the 60S ribosomal subunit
- Eukaryotic Translation Termination
- Regulation of expression of SLITs and ROBOs
- Response of EIF2AK4 (GCN2) to amino acid deficiency
- EML4 and NUDC in mitotic spindle formation
- Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
|
|
|
| RTN3 |
reticulon 3 |
- Synaptic adhesion-like molecules
|
|
|
| RTN4IP1 |
reticulon 4 interacting protein 1 |
|
|
|
| RTN4R |
reticulon 4 receptor |
- Axonal growth inhibition (RHOA activation)
|
|
|
| SNX1 |
sorting nexin 1 |
|
|
|
| SNX15 |
sorting nexin 15 |
|
|
|
| SPG21 |
SPG21 abhydrolase domain containing, maspardin |
|
|
- Hereditary spastic paraplegia (SPG)
|
| STON1 |
stonin 1 |
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
|
|
|
| SYT16 |
synaptotagmin 16 |
|
|
|
| TERF1 |
telomeric repeat binding factor 1 |
- Recognition and association of DNA glycosylase with site containing an affected pyrimidine
- Cleavage of the damaged pyrimidine
- Recognition and association of DNA glycosylase with site containing an affected purine
- Recognition and association of DNA glycosylase with site containing an affected purine
- Cleavage of the damaged purine
- Cleavage of the damaged purine
- Meiotic synapsis
- Packaging Of Telomere Ends
- Telomere Extension By Telomerase
- DNA Damage/Telomere Stress Induced Senescence
|
|
|
| TUBA4A |
tubulin alpha 4a |
- Platelet degranulation
- Translocation of SLC2A4 (GLUT4) to the plasma membrane
- Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
- Gap junction assembly
- MHC class II antigen presentation
- Separation of Sister Chromatids
- Resolution of Sister Chromatid Cohesion
- Regulation of PLK1 Activity at G2/M Transition
- HSP90 chaperone cycle for steroid hormone receptors (SHR)
- Loss of Nlp from mitotic centrosomes
- Recruitment of mitotic centrosome proteins and complexes
- Loss of proteins required for interphase microtubule organization from the centrosome
- Recruitment of NuMA to mitotic centrosomes
- Prefoldin mediated transfer of substrate to CCT/TriC
- Formation of tubulin folding intermediates by CCT/TriC
- Post-chaperonin tubulin folding pathway
- Recycling pathway of L1
- Recycling pathway of L1
- Hedgehog 'off' state
- Cilium Assembly
- Anchoring of the basal body to the plasma membrane
- Intraflagellar transport
- RHO GTPases activate IQGAPs
- RHO GTPases Activate Formins
- COPI-mediated anterograde transport
- COPI-dependent Golgi-to-ER retrograde traffic
- COPI-independent Golgi-to-ER retrograde traffic
- Mitotic Prometaphase
- The role of GTSE1 in G2/M progression after G2 checkpoint
- AURKA Activation by TPX2
- Carboxyterminal post-translational modifications of tubulin
- Carboxyterminal post-translational modifications of tubulin
- HCMV Early Events
- Assembly and cell surface presentation of NMDA receptors
- Activation of AMPK downstream of NMDARs
- Aggrephagy
- Aggrephagy
- EML4 and NUDC in mitotic spindle formation
- Sealing of the nuclear envelope (NE) by ESCRT-III
- Kinesins
|
- Vincristine
- Podofilox
- Epothilone D
- Patupilone
- CYT997
- S-8184
- Cabazitaxel
- Phenethyl Isothiocyanate
|
|
| UQCRC1 |
ubiquinol-cytochrome c reductase core protein 1 |
- Respiratory electron transport
|
- 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol
- Myxothiazol
- 5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole
- METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE
- (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE
- FAMOXADONE
- METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE
- 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE
- UBIQUINONE-2
|
|
| UQCRC2 |
ubiquinol-cytochrome c reductase core protein 2 |
- Respiratory electron transport
|
- 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol
- 5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole
- METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE
- (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE
- FAMOXADONE
- METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE
- 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE
- UBIQUINONE-2
|
|
| WWP1 |
WW domain containing E3 ubiquitin protein ligase 1 |
- Downregulation of ERBB4 signaling
- Stimuli-sensing channels
- Regulation of RUNX2 expression and activity
- Antigen processing: Ubiquitination & Proteasome degradation
|
|
|
| ZFYVE21 |
zinc finger FYVE-type containing 21 |
|
|
|