ACKR2 |
atypical chemokine receptor 2 |
- Chemokine receptors bind chemokines
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AGAP1 |
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 |
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AGAP2 |
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 |
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AKAP13 |
A-kinase anchoring protein 13 |
- NRAGE signals death through JNK
- Rho GTPase cycle
- G alpha (12/13) signalling events
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AMT |
aminomethyltransferase |
|
- Tetrahydrofolic acid
- NADH
- 5-methyltetrahydrofolic acid
|
- Nonketotic hyperglycinemia; Glycine encephalopathy (GCE)
|
ARF4 |
ADP ribosylation factor 4 |
- VxPx cargo-targeting to cilium
- VxPx cargo-targeting to cilium
- COPI-mediated anterograde transport
- COPI-dependent Golgi-to-ER retrograde traffic
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ARHGAP1 |
Rho GTPase activating protein 1 |
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ARHGAP10 |
Rho GTPase activating protein 10 |
- Rho GTPase cycle
- Regulation of PAK-2p34 activity by PS-GAP/RHG10
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ARHGAP21 |
Rho GTPase activating protein 21 |
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ARHGAP26 |
Rho GTPase activating protein 26 |
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ARHGAP32 |
Rho GTPase activating protein 32 |
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ARHGAP35 |
Rho GTPase activating protein 35 |
- Rho GTPase cycle
- Sema4D mediated inhibition of cell attachment and migration
- PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
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ARHGAP5 |
Rho GTPase activating protein 5 |
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ARHGAP8 |
Rho GTPase activating protein 8 |
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ARHGDIA |
Rho GDP dissociation inhibitor alpha |
- Axonal growth inhibition (RHOA activation)
- Rho GTPase cycle
- Axonal growth stimulation
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ARHGDIB |
Rho GDP dissociation inhibitor beta |
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ARHGDIG |
Rho GDP dissociation inhibitor gamma |
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ARHGEF1 |
Rho guanine nucleotide exchange factor 1 |
- NRAGE signals death through JNK
- Rho GTPase cycle
- G alpha (12/13) signalling events
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ARHGEF11 |
Rho guanine nucleotide exchange factor 11 |
- NRAGE signals death through JNK
- Rho GTPase cycle
- G alpha (12/13) signalling events
- Sema4D induced cell migration and growth-cone collapse
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ARHGEF12 |
Rho guanine nucleotide exchange factor 12 |
- NRAGE signals death through JNK
- Rho GTPase cycle
- G alpha (12/13) signalling events
- Sema4D induced cell migration and growth-cone collapse
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ARHGEF18 |
Rho/Rac guanine nucleotide exchange factor 18 |
- NRAGE signals death through JNK
- Rho GTPase cycle
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- G alpha (12/13) signalling events
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ARHGEF2 |
Rho/Rac guanine nucleotide exchange factor 2 |
- NRAGE signals death through JNK
- Rho GTPase cycle
- G alpha (12/13) signalling events
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ARHGEF25 |
Rho guanine nucleotide exchange factor 25 |
- G alpha (q) signalling events
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ARHGEF28 |
Rho guanine nucleotide exchange factor 28 |
- EPHB-mediated forward signaling
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ARHGEF3 |
Rho guanine nucleotide exchange factor 3 |
- NRAGE signals death through JNK
- Rho GTPase cycle
- G alpha (12/13) signalling events
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ARHGEF4 |
Rho guanine nucleotide exchange factor 4 |
- NRAGE signals death through JNK
- Rho GTPase cycle
- G alpha (12/13) signalling events
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ARIH2 |
ariadne RBR E3 ubiquitin protein ligase 2 |
- Antigen processing: Ubiquitination & Proteasome degradation
|
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ARNTL |
aryl hydrocarbon receptor nuclear translocator like |
- BMAL1:CLOCK,NPAS2 activates circadian gene expression
- BMAL1:CLOCK,NPAS2 activates circadian gene expression
- PPARA activates gene expression
- Circadian Clock
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BCR |
BCR activator of RhoGEF and GTPase |
- Signaling by cytosolic FGFR1 fusion mutants
- Rho GTPase cycle
- Signaling by FGFR1 in disease
|
- Dasatinib
- Bosutinib
- Ponatinib
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- Chronic myeloid leukemia (CML)
- Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
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BIRC2 |
baculoviral IAP repeat containing 2 |
- Apoptotic cleavage of cellular proteins
- NOD1/2 Signaling Pathway
- TICAM1, RIP1-mediated IKK complex recruitment
- RIPK1-mediated regulated necrosis
- Regulation of TNFR1 signaling
- TNFR1-induced NFkappaB signaling pathway
- TNFR2 non-canonical NF-kB pathway
- Regulation of necroptotic cell death
- TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
- Ub-specific processing proteases
- IKK complex recruitment mediated by RIP1
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C1QA |
complement C1q A chain |
- Initial triggering of complement
- Classical antibody-mediated complement activation
- Regulation of Complement cascade
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- Cetuximab
- Etanercept
- Adalimumab
- Abciximab
- Gemtuzumab ozogamicin
- Trastuzumab
- Rituximab
- Basiliximab
- Muromonab
- Ibritumomab tiuxetan
- Tositumomab
- Alemtuzumab
- Alefacept
- Efalizumab
- Natalizumab
- Palivizumab
- Daclizumab
- Bevacizumab
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- Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
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CAMP |
cathelicidin antimicrobial peptide |
- Neutrophil degranulation
- Antimicrobial peptides
|
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CAV1 |
caveolin 1 |
- Triglyceride catabolism
- eNOS activation
- NOSTRIN mediated eNOS trafficking
- Basigin interactions
- Disassembly of the destruction complex and recruitment of AXIN to the membrane
- VEGFR2 mediated vascular permeability
- Extra-nuclear estrogen signaling
- FOXO-mediated transcription of cell cycle genes
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- Congenital generalized lipodystrophy (CGL)
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CIT |
citron rho-interacting serine/threonine kinase |
- RHO GTPases activate CIT
- RHO GTPases activate CIT
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CLOCK |
clock circadian regulator |
- BMAL1:CLOCK,NPAS2 activates circadian gene expression
- BMAL1:CLOCK,NPAS2 activates circadian gene expression
- PPARA activates gene expression
- HATs acetylate histones
- Circadian Clock
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CNKSR1 |
connector enhancer of kinase suppressor of Ras 1 |
- MAP2K and MAPK activation
- Signaling by moderate kinase activity BRAF mutants
- Signaling by high-kinase activity BRAF mutants
- Signaling by BRAF and RAF fusions
- Paradoxical activation of RAF signaling by kinase inactive BRAF
- Signaling downstream of RAS mutants
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CNTNAP1 |
contactin associated protein 1 |
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DAAM1 |
dishevelled associated activator of morphogenesis 1 |
- PCP/CE pathway
- RHO GTPases Activate Formins
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DCUN1D1 |
defective in cullin neddylation 1 domain containing 1 |
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DEF6 |
DEF6 guanine nucleotide exchange factor |
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DGKQ |
diacylglycerol kinase theta |
- Effects of PIP2 hydrolysis
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DIAPH1 |
diaphanous related formin 1 |
- RHO GTPases Activate Formins
- ERBB2 Regulates Cell Motility
- Neutrophil degranulation
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DIAPH3 |
diaphanous related formin 3 |
- RHO GTPases Activate Formins
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DOCK7 |
dedicator of cytokinesis 7 |
- MET activates RAP1 and RAC1
- Factors involved in megakaryocyte development and platelet production
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DVL2 |
dishevelled segment polarity protein 2 |
- TCF dependent signaling in response to WNT
- WNT mediated activation of DVL
- Signaling by Hippo
- PCP/CE pathway
- PCP/CE pathway
- Asymmetric localization of PCP proteins
- Degradation of DVL
- Disassembly of the destruction complex and recruitment of AXIN to the membrane
- Disassembly of the destruction complex and recruitment of AXIN to the membrane
- WNT5A-dependent internalization of FZD4
- Negative regulation of TCF-dependent signaling by DVL-interacting proteins
- RHO GTPases Activate Formins
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- WNT5:FZD7-mediated leishmania damping
- WNT5:FZD7-mediated leishmania damping
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ENTPD3 |
ectonucleoside triphosphate diphosphohydrolase 3 |
- Phosphate bond hydrolysis by NTPDase proteins
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FLNA |
filamin A |
- Platelet degranulation
- GP1b-IX-V activation signalling
- Cell-extracellular matrix interactions
- RHO GTPases activate PAKs
- OAS antiviral response
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- Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
- Fronto-Otopalatodigital Osteodysplasia, including: Otopalatodigital syndrome, type I; Otopalatodigital syndrome, type II; Melnick-Needles syndrome; Frontometaphyseal dysplasia
- Periventricular nodular heterotopia (PVNH)
- FG syndrome (FGS); Opitz-Kaveggia syndrome
|
FMN2 |
formin 2 |
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GMIP |
GEM interacting protein |
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GPX1 |
glutathione peroxidase 1 |
- Synthesis of 5-eicosatetraenoic acids
- Synthesis of 12-eicosatetraenoic acid derivatives
- Synthesis of 15-eicosatetraenoic acid derivatives
- Detoxification of Reactive Oxygen Species
- Purine catabolism
|
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- Anemia due to disorders of glutathione metabolism, including: Glucose-6-phosphate dehydrogenase (G6PD) deficiency; Glutathione peroxidase (GPX) deficiency; Gamma-glutamylcysteine synthetase (GCLC) deficiency; Glutathione synthetase (GSS) deficiency
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HSPA1A |
heat shock protein family A (Hsp70) member 1A |
- Viral RNP Complexes in the Host Cell Nucleus
- Regulation of HSF1-mediated heat shock response
- HSP90 chaperone cycle for steroid hormone receptors (SHR)
- Attenuation phase
- HSF1-dependent transactivation
- AUF1 (hnRNP D0) binds and destabilizes mRNA
- Neutrophil degranulation
- Regulation of HSF1-mediated heat shock response
- HSP90 chaperone cycle for steroid hormone receptors (SHR)
- Attenuation phase
- HSF1-dependent transactivation
- Neutrophil degranulation
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ICMT |
isoprenylcysteine carboxyl methyltransferase |
- Gamma carboxylation, hypusine formation and arylsulfatase activation
|
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IKBKG |
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma |
- Activation of NF-kappaB in B cells
- Activation of NF-kappaB in B cells
- ER-Phagosome pathway
- NOD1/2 Signaling Pathway
- TICAM1, RIP1-mediated IKK complex recruitment
- RIP-mediated NFkB activation via ZBP1
- Downstream TCR signaling
- FCERI mediated NF-kB activation
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- activated TAK1 mediates p38 MAPK activation
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- SUMOylation of immune response proteins
- Regulation of TNFR1 signaling
- TNFR1-induced NFkappaB signaling pathway
- IKBKB deficiency causes SCID
- IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
- IkBA variant leads to EDA-ID
- CLEC7A (Dectin-1) signaling
- MAP3K8 (TPL2)-dependent MAPK1/3 activation
- Ub-specific processing proteases
- Ovarian tumor domain proteases
- Interleukin-1 signaling
- TRAF6 mediated NF-kB activation
- NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
- IRAK1 recruits IKK complex
- IKK complex recruitment mediated by RIP1
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
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- Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases: NF-kappa-B essential modulator (NEMO) defect; Inhibitor of kappa-B (I-kappa-B) defect
- Incontinentia pigmenti
- Osteoporosis, lymphedema, anhydrotic ectodermal dysplasia with immunodeficiency (OLEDAID); Ectodermal dysplasia, anhidrotic, with immunodeficiency, osteopetrosis, and lymphedema
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IKZF3 |
IKAROS family zinc finger 3 |
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ITIH3 |
inter-alpha-trypsin inhibitor heavy chain 3 |
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ITPR1 |
inositol 1,4,5-trisphosphate receptor type 1 |
- PLC beta mediated events
- Effects of PIP2 hydrolysis
- Elevation of cytosolic Ca2+ levels
- DAG and IP3 signaling
- Role of phospholipids in phagocytosis
- FCERI mediated Ca+2 mobilization
- Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
- Ca2+ pathway
- cGMP effects
- Regulation of insulin secretion
- VEGFR2 mediated cell proliferation
- Ion homeostasis
- Ion homeostasis
- CLEC7A (Dectin-1) induces NFAT activation
- FCGR3A-mediated IL10 synthesis
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
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- Caffeine
- 1D-myo-inositol 1,4,5-trisphosphate
- Glycerin
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- Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
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KCNA2 |
potassium voltage-gated channel subfamily A member 2 |
- Voltage gated Potassium channels
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KCTD13 |
potassium channel tetramerization domain containing 13 |
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KLRG1 |
killer cell lectin like receptor G1 |
- Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
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KTN1 |
kinectin 1 |
- Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
- RHO GTPases activate KTN1
- Post-translational protein phosphorylation
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LRP2 |
LDL receptor related protein 2 |
- Vitamin D (calciferol) metabolism
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- Retinoid metabolism and transport
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- Urokinase
- Insulin Human
- Insulin Pork
- Gentamicin
|
- Donnai-Barrow syndrome; Faciooculoacousticorenal syndrome
|
MCF2 |
MCF.2 cell line derived transforming sequence |
- Axonal growth inhibition (RHOA activation)
- NRAGE signals death through JNK
- Rho GTPase cycle
- G alpha (12/13) signalling events
|
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MCF2L |
MCF.2 cell line derived transforming sequence like |
- NRAGE signals death through JNK
- Rho GTPase cycle
- G alpha (12/13) signalling events
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MPRIP |
myosin phosphatase Rho interacting protein |
- Signaling by BRAF and RAF fusions
|
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NET1 |
neuroepithelial cell transforming 1 |
- NRAGE signals death through JNK
- Rho GTPase cycle
- G alpha (12/13) signalling events
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NOTCH1 |
notch receptor 1 |
- Pre-NOTCH Processing in the Endoplasmic Reticulum
- Pre-NOTCH Transcription and Translation
- Pre-NOTCH Transcription and Translation
- Pre-NOTCH Processing in Golgi
- Pre-NOTCH Processing in Golgi
- Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
- NOTCH1 Intracellular Domain Regulates Transcription
- NOTCH1 Intracellular Domain Regulates Transcription
- Activated NOTCH1 Transmits Signal to the Nucleus
- Activated NOTCH1 Transmits Signal to the Nucleus
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
- Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Constitutive Signaling by NOTCH1 HD Domain Mutants
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Notch-HLH transcription pathway
- Defective LFNG causes SCDO3
- RUNX3 regulates NOTCH signaling
- RUNX3 regulates NOTCH signaling
- NOTCH3 Intracellular Domain Regulates Transcription
- NOTCH3 Intracellular Domain Regulates Transcription
- NOTCH4 Intracellular Domain Regulates Transcription
|
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- Bicuspid aortic valve
- Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
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OPHN1 |
oligophrenin 1 |
|
|
- Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
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OTUB1 |
OTU deubiquitinase, ubiquitin aldehyde binding 1 |
- Ub-specific processing proteases
- Ovarian tumor domain proteases
|
|
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PDCD10 |
programmed cell death 10 |
|
|
- Cerebral cavernous malformation
|
PDE6D |
phosphodiesterase 6D |
- ARL13B-mediated ciliary trafficking of INPP5E
|
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|
PITPNM1 |
phosphatidylinositol transfer protein membrane associated 1 |
|
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PKN1 |
protein kinase N1 |
- RHO GTPases activate PKNs
- Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
|
|
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PKN2 |
protein kinase N2 |
- RHO GTPases activate PKNs
|
|
|
PLCG1 |
phospholipase C gamma 1 |
- ISG15 antiviral mechanism
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- PLCG1 events in ERBB2 signaling
- DAG and IP3 signaling
- PLC-gamma1 signalling
- Synthesis of IP3 and IP4 in the cytosol
- Downstream signal transduction
- Generation of second messenger molecules
- Role of phospholipids in phagocytosis
- Role of phospholipids in phagocytosis
- PECAM1 interactions
- EGFR interacts with phospholipase C-gamma
- DAP12 signaling
- FCERI mediated MAPK activation
- FCERI mediated Ca+2 mobilization
- FCERI mediated Ca+2 mobilization
- Role of second messengers in netrin-1 signaling
- VEGFR2 mediated cell proliferation
- VEGFR2 mediated cell proliferation
- Constitutive Signaling by EGFRvIII
- Phospholipase C-mediated cascade: FGFR1
- Phospholipase C-mediated cascade; FGFR2
- Phospholipase C-mediated cascade; FGFR3
- Phospholipase C-mediated cascade; FGFR4
- Signaling by FGFR2 in disease
- Signaling by FGFR4 in disease
- Signaling by FGFR1 in disease
- Signaling by FGFR3 point mutants in cancer
- RET signaling
- Activated NTRK2 signals through PLCG1
- Activated NTRK2 signals through PLCG1
- Erythropoietin activates Phospholipase C gamma (PLCG)
- Activated NTRK3 signals through PLCG1
- Activated NTRK3 signals through PLCG1
- FCGR3A-mediated IL10 synthesis
- Signaling by ERBB2 KD Mutants
- Signaling by ERBB2 ECD mutants
- Signaling by ERBB2 TMD/JMD mutants
|
|
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PLD1 |
phospholipase D1 |
- Synthesis of PG
- Synthesis of PA
- Role of phospholipids in phagocytosis
- Neutrophil degranulation
|
|
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PLEKHG2 |
pleckstrin homology and RhoGEF domain containing G2 |
- NRAGE signals death through JNK
- Rho GTPase cycle
- G alpha (12/13) signalling events
|
|
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PPP1R12A |
protein phosphatase 1 regulatory subunit 12A |
- Regulation of PLK1 Activity at G2/M Transition
- RHO GTPases activate PKNs
- RHO GTPases activate PKNs
- RHO GTPases activate CIT
- RHO GTPases Activate ROCKs
- RHO GTPases activate PAKs
- RHO GTPases activate PAKs
|
|
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PRKACA |
protein kinase cAMP-activated catalytic subunit alpha |
- PKA-mediated phosphorylation of CREB
- PKA-mediated phosphorylation of key metabolic factors
- Triglyceride catabolism
- PKA activation
- PKA activation in glucagon signalling
- DARPP-32 events
- Regulation of PLK1 Activity at G2/M Transition
- Loss of Nlp from mitotic centrosomes
- Recruitment of mitotic centrosome proteins and complexes
- Loss of proteins required for interphase microtubule organization from the centrosome
- Recruitment of NuMA to mitotic centrosomes
- Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
- Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
- Rap1 signalling
- Regulation of insulin secretion
- Vasopressin regulates renal water homeostasis via Aquaporins
- VEGFA-VEGFR2 Pathway
- CREB1 phosphorylation through the activation of Adenylate Cyclase
- CREB1 phosphorylation through the activation of Adenylate Cyclase
- Interleukin-3, Interleukin-5 and GM-CSF signaling
- Ion homeostasis
- Degradation of GLI1 by the proteasome
- Degradation of GLI2 by the proteasome
- GLI3 is processed to GLI3R by the proteasome
- Hedgehog 'off' state
- Anchoring of the basal body to the plasma membrane
- CD209 (DC-SIGN) signaling
- MAPK6/MAPK4 signaling
- RET signaling
- AURKA Activation by TPX2
- HDL assembly
- ROBO receptors bind AKAP5
- Loss of phosphorylation of MECP2 at T308
- Regulation of MECP2 expression and activity
- Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
- ADORA2B mediated anti-inflammatory cytokines production
- ADORA2B mediated anti-inflammatory cytokines production
- FCGR3A-mediated IL10 synthesis
- FCGR3A-mediated IL10 synthesis
- Factors involved in megakaryocyte development and platelet production
|
- Pentanal
- Balanol Analog 2
- Balanol Analog 8
- Phosphonothreonine
- Balanol Analog 1
- 3,5-Diiodotyrosine
- Balanol
- Dexfosfoserine
- S,S-(2-Hydroxyethyl)Thiocysteine
- Hydroxyfasudil
- (1S)-2-(1H-INDOL-3-YL)-1-{[(5-ISOQUINOLIN-6-YLPYRIDIN-3-YL)OXY]METHYL}ETHYLAMINE
- (2S)-1-{[5-(1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}-3-[(7AS)-7AH-INDOL-3-YL]PROPAN-2-AMINE
- (1S)-2-(1H-INDOL-3-YL)-1-[({5-[(E)-2-PYRIDIN-4-YLVINYL]PYRIDIN-3-YL}OXY)METHYL]ETHYLAMINE
- (2S)-1-(6H-INDOL-3-YL)-3-{[5-(7H-PYRAZOLO[3,4-C]PYRIDIN-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
- (1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINE
- N-[(1S)-2-AMINO-1-(2,4-DICHLOROBENZYL)ETHYL]-5-[2-(METHYLAMINO)PYRIMIDIN-4-YL]THIOPHENE-2-CARBOXAMIDE
- 3-(1H-indol-3-yl)-4-{1-[2-(1-methylpyrrolidin-2-yl)ethyl]-1H-indol-3-yl}-1H-pyrrole-2,5-dione
- (4R,2S)-5'-(4-(4-CHLOROBENZYLOXY)PYRROLIDIN-2-YLMETHANESULFONYL)ISOQUINOLINE
- N-METHYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE
- (S)-1-PHENYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE
- 6-{4-[4-(4-CHLOROPHENYL)PIPERIDIN-4-YL]PHENYL}-9H-PURINE
- (2R)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamine
- (2S)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamine
- 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE
- (2R)-2-(4-CHLOROPHENYL)-2-PHENYLETHANAMINE
- (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE
- ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE
- N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE
- 5-(2-methylpiperazine-1-sulfonyl)isoquinoline
- N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE
- 2-[4-(3-METHYL-1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE
- (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
- 3-pyridin-4-yl-1H-indazole
- 5-benzyl-1,3-thiazol-2-amine
- 1-[4-(4-chlorophenyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine
- 1-[4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine
- 4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminium
- Fasudil
- Myristic acid
- (2S)-1-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}-3-PHENYLPROPAN-2-AMINE
- 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.] PYRAZOLE
- (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE
- Ellagic Acid
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PRKCA |
protein kinase C alpha |
- Calmodulin induced events
- Disinhibition of SNARE formation
- SHC1 events in ERBB2 signaling
- Signaling by SCF-KIT
- Regulation of KIT signaling
- EGFR Transactivation by Gastrin
- Inactivation, recovery and regulation of the phototransduction cascade
- Syndecan interactions
- Acetylcholine regulates insulin secretion
- Ca2+ pathway
- Trafficking of GluR2-containing AMPA receptors
- G alpha (z) signalling events
- Depolymerisation of the Nuclear Lamina
- HuR (ELAVL1) binds and stabilizes mRNA
- WNT5A-dependent internalization of FZD4
- VEGFR2 mediated cell proliferation
- RHO GTPases Activate NADPH Oxidases
- Response to elevated platelet cytosolic Ca2+
- RET signaling
- ROBO receptors bind AKAP5
- ROBO receptors bind AKAP5
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- Phosphatidyl serine
- Vitamin E
- Tamoxifen
- Ingenol Mebutate
- Midostaurin
- Ellagic Acid
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PRKCZ |
protein kinase C zeta |
- GPVI-mediated activation cascade
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- VEGFR2 mediated cell proliferation
- RHO GTPases Activate NADPH Oxidases
- Estrogen-stimulated signaling through PRKCZ
- Estrogen-stimulated signaling through PRKCZ
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PTPRF |
protein tyrosine phosphatase receptor type F |
- Receptor-type tyrosine-protein phosphatases
- Synaptic adhesion-like molecules
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RABAC1 |
Rab acceptor 1 |
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RACK1 |
receptor for activated C kinase 1 |
- Regulation of TNFR1 signaling
- TNFR1-induced NFkappaB signaling pathway
- TNFR1-mediated ceramide production
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RAP1GDS1 |
Rap1 GTPase-GDP dissociation stimulator 1 |
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RASGRF1 |
Ras protein specific guanine nucleotide releasing factor 1 |
- Ras activation upon Ca2+ influx through NMDA receptor
- RAF/MAP kinase cascade
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RASSF1 |
Ras association domain family member 1 |
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- Non-small cell lung cancer
- Bladder cancer
- Nasopharyngeal cancer
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RHPN1 |
rhophilin Rho GTPase binding protein 1 |
- RHO GTPases Activate Rhotekin and Rhophilins
- RHO GTPases Activate Rhotekin and Rhophilins
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RHPN2 |
rhophilin Rho GTPase binding protein 2 |
- RHO GTPases Activate Rhotekin and Rhophilins
- RHO GTPases Activate Rhotekin and Rhophilins
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RIPK4 |
receptor interacting serine/threonine kinase 4 |
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RIPOR2 |
RHO family interacting cell polarization regulator 2 |
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ROCK1 |
Rho associated coiled-coil containing protein kinase 1 |
- Apoptotic cleavage of cellular proteins
- EPHB-mediated forward signaling
- EPHB-mediated forward signaling
- EPHA-mediated growth cone collapse
- G alpha (12/13) signalling events
- Sema4D induced cell migration and growth-cone collapse
- Sema4D induced cell migration and growth-cone collapse
- VEGFA-VEGFR2 Pathway
- RHO GTPases Activate ROCKs
- RHO GTPases Activate ROCKs
- Neutrophil degranulation
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- Hydroxyfasudil
- (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE
- Fasudil
- (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE
- Ripasudil
- Netarsudil
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RPN2 |
ribophorin II |
- SRP-dependent cotranslational protein targeting to membrane
- Asparagine N-linked glycosylation
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RTKN |
rhotekin |
- RHO GTPases Activate Rhotekin and Rhophilins
- RHO GTPases Activate Rhotekin and Rhophilins
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SH3BP1 |
SH3 domain binding protein 1 |
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SMAD2 |
SMAD family member 2 |
- Signaling by NODAL
- Signaling by NODAL
- Signaling by Activin
- Downregulation of TGF-beta receptor signaling
- TGF-beta receptor signaling activates SMADs
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- SMAD4 MH2 Domain Mutants in Cancer
- SMAD2/3 MH2 Domain Mutants in Cancer
- TGFBR1 KD Mutants in Cancer
- Transcriptional regulation of pluripotent stem cells
- Ub-specific processing proteases
- FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
- FOXO-mediated transcription of cell cycle genes
- FOXO-mediated transcription of cell cycle genes
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SMURF1 |
SMAD specific E3 ubiquitin protein ligase 1 |
- Signaling by BMP
- Downregulation of TGF-beta receptor signaling
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- Asymmetric localization of PCP proteins
- Hedgehog 'on' state
- Hedgehog 'on' state
- Regulation of RUNX2 expression and activity
- Regulation of RUNX2 expression and activity
- Regulation of RUNX3 expression and activity
- Antigen processing: Ubiquitination & Proteasome degradation
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SMURF2 |
SMAD specific E3 ubiquitin protein ligase 2 |
- Signaling by BMP
- Downregulation of TGF-beta receptor signaling
- Downregulation of TGF-beta receptor signaling
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- Asymmetric localization of PCP proteins
- Degradation of AXIN
- Hedgehog 'on' state
- Hedgehog 'on' state
- Ub-specific processing proteases
- Regulation of RUNX3 expression and activity
- Antigen processing: Ubiquitination & Proteasome degradation
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SPRED2 |
sprouty related EVH1 domain containing 2 |
- Regulation of RAS by GAPs
- FGFRL1 modulation of FGFR1 signaling
- RAS signaling downstream of NF1 loss-of-function variants
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SRGAP1 |
SLIT-ROBO Rho GTPase activating protein 1 |
- Rho GTPase cycle
- Inactivation of CDC42 and RAC1
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SUB1 |
SUB1 regulator of transcription |
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TGFBR1 |
transforming growth factor beta receptor 1 |
- Downregulation of TGF-beta receptor signaling
- Downregulation of TGF-beta receptor signaling
- TGF-beta receptor signaling activates SMADs
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- TGFBR1 KD Mutants in Cancer
- TGFBR1 LBD Mutants in Cancer
- UCH proteinases
- Ub-specific processing proteases
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- 4-(3-Pyridin-2-Yl-1h-Pyrazol-4-Yl)Quinoline
- Naphthyridine Inhibitor
- 3-(4-Fluorophenyl)-2-(6-Methylpyridin-2-Yl)-5,6-Dihydro-4h-Pyrrolo[1,2-B]Pyrazole
- N-[4-(5-fluoro-6-methylpyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]acetamide
- 2-(6-methylpyridin-2-yl)-N-pyridin-4-ylquinazolin-4-amine
- N-1H-indazol-5-yl-2-(6-methylpyridin-2-yl)quinazolin-4-amine
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- Loeys-Dietz syndrome (LDS)
- Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
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TGM2 |
transglutaminase 2 |
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TNFAIP1 |
TNF alpha induced protein 1 |
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TRIO |
trio Rho guanine nucleotide exchange factor |
- NRAGE signals death through JNK
- Rho GTPase cycle
- G alpha (q) signalling events
- G alpha (12/13) signalling events
- DCC mediated attractive signaling
- DCC mediated attractive signaling
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TRIP6 |
thyroid hormone receptor interactor 6 |
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TRPC1 |
transient receptor potential cation channel subfamily C member 1 |
- TRP channels
- Role of second messengers in netrin-1 signaling
- Ion homeostasis
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
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VAV1 |
vav guanine nucleotide exchange factor 1 |
- GPVI-mediated activation cascade
- GPVI-mediated activation cascade
- PIP3 activates AKT signaling
- Signaling by SCF-KIT
- NRAGE signals death through JNK
- Rho GTPase cycle
- Regulation of actin dynamics for phagocytic cup formation
- Constitutive Signaling by Aberrant PI3K in Cancer
- FCERI mediated MAPK activation
- FCERI mediated Ca+2 mobilization
- FCERI mediated Ca+2 mobilization
- CD28 dependent Vav1 pathway
- G alpha (12/13) signalling events
- VEGFA-VEGFR2 Pathway
- VEGFA-VEGFR2 Pathway
- Interleukin-3, Interleukin-5 and GM-CSF signaling
- VEGFR2 mediated vascular permeability
- PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
- Erythropoietin activates RAS
- Erythropoietin activates RAS
- Regulation of signaling by CBL
- FCGR3A-mediated phagocytosis
- FCGR3A-mediated phagocytosis
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
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VAV2 |
vav guanine nucleotide exchange factor 2 |
- GPVI-mediated activation cascade
- GPVI-mediated activation cascade
- NRAGE signals death through JNK
- Rho GTPase cycle
- Regulation of actin dynamics for phagocytic cup formation
- DAP12 signaling
- FCERI mediated MAPK activation
- FCERI mediated Ca+2 mobilization
- FCERI mediated Ca+2 mobilization
- EPH-ephrin mediated repulsion of cells
- G alpha (12/13) signalling events
- VEGFA-VEGFR2 Pathway
- VEGFA-VEGFR2 Pathway
- Signal transduction by L1
- VEGFR2 mediated vascular permeability
- FCGR3A-mediated phagocytosis
- FCGR3A-mediated phagocytosis
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VAV3 |
vav guanine nucleotide exchange factor 3 |
- GPVI-mediated activation cascade
- GPVI-mediated activation cascade
- NRAGE signals death through JNK
- Rho GTPase cycle
- Regulation of actin dynamics for phagocytic cup formation
- DAP12 signaling
- FCERI mediated MAPK activation
- FCERI mediated Ca+2 mobilization
- FCERI mediated Ca+2 mobilization
- EPH-ephrin mediated repulsion of cells
- G alpha (12/13) signalling events
- VEGFA-VEGFR2 Pathway
- VEGFA-VEGFR2 Pathway
- VEGFR2 mediated vascular permeability
- FCGR3A-mediated phagocytosis
- FCGR3A-mediated phagocytosis
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