PRKAR2A - Wiki-CORONA

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
AKAP1	A-kinase anchoring protein 1	Mitochondrial calcium ion transport Factors involved in megakaryocyte development and platelet production
AKAP10	A-kinase anchoring protein 10	Factors involved in megakaryocyte development and platelet production
AKAP11	A-kinase anchoring protein 11
AKAP12	A-kinase anchoring protein 12
AKAP13	A-kinase anchoring protein 13	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
AKAP14	A-kinase anchoring protein 14
AKAP3	A-kinase anchoring protein 3
AKAP4	A-kinase anchoring protein 4
AKAP5	A-kinase anchoring protein 5	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Trafficking of AMPA receptors ROBO receptors bind AKAP5 ROBO receptors bind AKAP5
AKAP6	A-kinase anchoring protein 6
AKAP7	A-kinase anchoring protein 7
AKAP8	A-kinase anchoring protein 8
AKAP9	A-kinase anchoring protein 9	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Phase 3 - rapid repolarisation Phase 2 - plateau phase Anchoring of the basal body to the plasma membrane Signaling by BRAF and RAF fusions AURKA Activation by TPX2		Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
APBB1	amyloid beta precursor protein binding family B member 1	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
ARFGEF2	ADP ribosylation factor guanine nucleotide exchange factor 2	Association of TriC/CCT with target proteins during biosynthesis		Periventricular nodular heterotopia (PVNH)
CBFA2T3	CBFA2/RUNX1 partner transcriptional co-repressor 3
CFTR	CF transmembrane conductance regulator	ABC-family proteins mediated transport RHO GTPases regulate CFTR trafficking Defective CFTR causes cystic fibrosis Ub-specific processing proteases Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy	ATP Bumetanide Glyburide Ibuprofen Colforsin Phosphoaminophosphonic Acid-Adenylate Ester Dexfosfoserine Crofelemer Lonidamine Ivacaftor Dexibuprofen Lumacaftor	Cystic fibrosis (CF) Hereditary pancreatitis; Hereditary chronic pancreatitis Congenital bilateral absence of vas deferens
EZR	ezrin	Netrin-1 signaling Recycling pathway of L1 Recycling pathway of L1
GABARAPL2	GABA type A receptor associated protein like 2	Macroautophagy TBC/RABGAPs
HYAL1	hyaluronidase 1	CS/DS degradation Hyaluronan uptake and degradation MPS IX - Natowicz syndrome		Mucopolysaccharidosis type IX (MPS9); Hyaluronidase deficiency
MAP2	microtubule associated protein 2		Estramustine Paclitaxel Docetaxel
MSN	moesin	Recycling pathway of L1 Recycling pathway of L1 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
MYCBPAP	MYCBP associated protein
NBEA	neurobeachin	Neurotransmitter receptors and postsynaptic signal transmission PKA activation NOTCH1 Intracellular Domain Regulates Transcription Assembly and cell surface presentation of NMDA receptors
P4HA2	prolyl 4-hydroxylase subunit alpha 2	Collagen biosynthesis and modifying enzymes	Succinic acid L-Proline
PJA2	praja ring finger ubiquitin ligase 2	Antigen processing: Ubiquitination & Proteasome degradation
PPP1CB	protein phosphatase 1 catalytic subunit beta	Triglyceride catabolism Downregulation of TGF-beta receptor signaling Regulation of PLK1 Activity at G2/M Transition Circadian Clock RHO GTPases activate PKNs RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs
PRKX	protein kinase X-linked	PKA-mediated phosphorylation of CREB CREB1 phosphorylation through the activation of Adenylate Cyclase ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis
RAB32	RAB32, member RAS oncogene family	RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
RBM6	RNA binding motif protein 6
RET	ret proto-oncogene	RAF/MAP kinase cascade RET signaling	Sorafenib 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Vandetanib Cabozantinib Regorafenib Ponatinib Amuvatinib	Hirschsprung disease (HD) Renal agenesis and Renal adysplasia Thyroid cancer Congenital central hypoventilation syndrome (CCHS)
RPL29	ribosomal protein L29	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
RUNX1T1	RUNX1 partner transcriptional co-repressor 1			Acute myeloid leukemia (AML)
RYR2	ryanodine receptor 2	Stimuli-sensing channels Ion homeostasis	Tetracaine	Arrhythmogenic right ventricular cardiomyopathy (ARVC) Catecholaminergic polymorphic ventricular tachycardia
SCTR	secretin receptor	G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production	Secretin
SEMG2	semenogelin 2
SMAD3	SMAD family member 3	Signaling by NODAL Signaling by NODAL Signaling by Activin Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/3 Phosphorylation Motif Mutants in Cancer SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Ub-specific processing proteases RUNX3 regulates CDKN1A transcription RUNX3 regulates BCL2L11 (BIM) transcription Interleukin-37 signaling NOTCH4 Intracellular Domain Regulates Transcription FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes
SMAD4	SMAD family member 4	Signaling by NODAL Signaling by Activin Signaling by BMP TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Transcriptional regulation of pluripotent stem cells Ub-specific processing proteases RUNX2 regulates bone development RUNX3 regulates CDKN1A transcription RUNX3 regulates BCL2L11 (BIM) transcription FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes		Colorectal cancer Hereditary hemorrhagic telangiectasia (HHT) Pancreatic cancer Juvenile polyposis syndrome
TCAIM	T cell activation inhibitor, mitochondrial
WASF1	WASP family member 1	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
XCR1	X-C motif chemokine receptor 1	Chemokine receptors bind chemokines G alpha (q) signalling events

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