POR - Wiki-CORONA

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
CYB5A	cytochrome b5 type A	Vitamin C (ascorbate) metabolism	Dimethyl Propionate Ester Heme	Methemoglobinemia
CYP17A1	cytochrome P450 family 17 subfamily A member 1	Androgen biosynthesis Glucocorticoid biosynthesis Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)	NADH Progesterone Abiraterone	46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS) Congenital adrenal hyperplasia (CAH)
CYP1A2	cytochrome P450 family 1 subfamily A member 2	Methylation Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Aflatoxin activation and detoxification Biosynthesis of protectins Biosynthesis of maresin-like SPMs	Isoniazid 2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE Diacerein
CYP2A6	cytochrome P450 family 2 subfamily A member 6	Xenobiotics CYP2E1 reactions	Coumarin N,N-DIMETHYL(5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINE N-METHYL(5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINE (5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINE 4,4'-DIPYRIDYL DISULFIDE
CYP2C19	cytochrome P450 family 2 subfamily C member 19	Xenobiotics CYP2E1 reactions Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	Isoniazid Benzbromarone
CYP2C9	cytochrome P450 family 2 subfamily C member 9	Xenobiotics CYP2E1 reactions Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Biosynthesis of maresin-like SPMs	4-Hydroxy-3-[(1s)-3-Oxo-1-Phenylbutyl]-2h-Chromen-2-One Heme C Diacerein Benzbromarone
CYP2D6	cytochrome P450 family 2 subfamily D member 6	Fatty acids Miscellaneous substrates Xenobiotics CYP2E1 reactions Biosynthesis of maresin-like SPMs	Paliperidone Diacerein
CYP2E1	cytochrome P450 family 2 subfamily E member 1	Xenobiotics CYP2E1 reactions Biosynthesis of maresin-like SPMs	Diacerein
CYP3A4	cytochrome P450 family 3 subfamily A member 4	Xenobiotics Aflatoxin activation and detoxification Biosynthesis of maresin-like SPMs	Glutathione Isoniazid Paliperidone Pradefovir Mesylate Diacerein
EHMT2	euchromatic histone lysine methyltransferase 2	Senescence-Associated Secretory Phenotype (SASP) PKMTs methylate histone lysines ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Methylation RNA Polymerase I Transcription Initiation Transcriptional Regulation by VENTX Transcriptional Regulation by E2F6
FANCC	FA complementation group C	Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes		Fanconi anemia
HMOX1	heme oxygenase 1	Heme degradation Interleukin-4 and Interleukin-13 signaling Iron uptake and transport Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	NADH Formic Acid Biliverdine IX Alpha 12-Phenylheme 2-Phenylheme Verdoheme Stannsoporfin 1-({2-[2-(4-CHLOROPHENYL)ETHYL]-1,3-DIOXOLAN-2-YL}METHYL)-1H-IMIDAZOLE 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone
PSPHP1	phosphoserine phosphatase pseudogene 1
RABEPK	Rab9 effector protein with kelch motifs	Retrograde transport at the Trans-Golgi-Network
RPS4X	ribosomal protein S4 X-linked	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SIN3B	SIN3 transcription regulator family member B	NoRC negatively regulates rRNA expression RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
SLC39A2	solute carrier family 39 member 2	Zinc influx into cells by the SLC39 gene family
STAT1	signal transducer and activator of transcription 1	Interleukin-6 signaling ISG15 antiviral mechanism Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction Interleukin-4 and Interleukin-13 signaling Interleukin-20 family signaling Regulation of RUNX2 expression and activity Interleukin-35 Signalling Interleukin-9 signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription Interleukin-27 signaling Interleukin-21 signaling Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Growth hormone receptor signaling		Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF) IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
TGFBI	transforming growth factor beta induced	Amyloid fiber formation		Granular corneal dystrophies (GCD), including: Corneal dystrophy Groenouw type I; Avellino corneal dystrophy; Granular-lattice dystrophy Lattice corneal dystrophies (LCD), including: Biber-Haab-Dimmer dystrophy; Familial amyloid polyneuropathy type IV; Meretoja syndrome Reis-Bucklers corneal dystrophy (RBCD); Corneal dystrophy of Bowman's type I; Granular corneal dystrophy type III Thiel-Behnke dystrophies (TBCD); Corneal dystrophy of Bowman layer type II; Honeycomb corneal dystrophy; Anterior limiting membrane dystrophy type II; Curly fibers corneal dystrophy; Waardenburg-Jonker corneal dystrophy
XRCC6	X-ray repair cross complementing 6	2-LTR circle formation Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) Neutrophil degranulation

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