PLEKHF2 - Wiki-CORONA

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
ACY3	aminoacylase 3	Aflatoxin activation and detoxification	L-Aspartic Acid
AIDA	axin interactor, dorsalization associated
AIMP2	aminoacyl tRNA synthetase complex interacting multifunctional protein 2	Selenoamino acid metabolism Cytosolic tRNA aminoacylation
APP	amyloid beta precursor protein	Platelet degranulation ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (q) signalling events G alpha (i) signalling events Lysosome Vesicle Biogenesis Formyl peptide receptors bind formyl peptides and many other ligands TAK1 activates NFkB by phosphorylation and activation of IKKs complex The NLRP3 inflammasome Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Post-translational protein phosphorylation TRAF6 mediated NF-kB activation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Purinergic signaling in leishmaniasis infection Amyloid fiber formation	Deferoxamine Aluminium Zinc L-methionine (R)-S-oxide Resveratrol Phenserine Tiomolibdate ion CAD106 Mito-4509 Dimercaprol Copper Florbetaben (18F) Florbetapir (18F) Flutemetamol (18F)	Alzheimer's disease (AD)
APPL1	adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1	Caspase activation via Dependence Receptors in the absence of ligand
ARL14EP	ADP ribosylation factor like GTPase 14 effector protein
BEND7	BEN domain containing 7
BLOC1S6	biogenesis of lysosomal organelles complex 1 subunit 6	Golgi Associated Vesicle Biogenesis
BSCL2	BSCL2 lipid droplet biogenesis associated, seipin			Hereditary spastic paraplegia (SPG) Congenital generalized lipodystrophy (CGL) Distal hereditary motor neuropathies (dHMN)
CAVIN2	caveolae associated protein 2
CCDC172	coiled-coil domain containing 172
CCDC85B	coiled-coil domain containing 85B
CEP44	centrosomal protein 44
CGGBP1	CGG triplet repeat binding protein 1
CHIC2	cysteine rich hydrophobic domain 2
DPPA4	developmental pluripotency associated 4	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
DRAP1	DR1 associated protein 1	Signaling by NODAL Signaling by Activin
DTX2	deltex E3 ubiquitin ligase 2	Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus
DUT	deoxyuridine triphosphatase		Deoxyuridine-5'-Diphosphate 1-{(2S,5S)-4-FLUORO-5-[(TRITYLOXY)METHYL]TETRAHYDROFURAN-2-YL}PYRIMIDINE-2,4(1H,3H)-DIONE
ESRP1	epithelial splicing regulatory protein 1	Signaling by BRAF and RAF fusions FGFR2 alternative splicing
FBXO28	F-box protein 28
FHL3	four and a half LIM domains 3
FOXA1	forkhead box A1	Estrogen-dependent gene expression
FRMD8	FERM domain containing 8
GFER	growth factor, augmenter of liver regeneration	Mitochondrial protein import	Flavin adenine dinucleotide
GLUL	glutamate-ammonia ligase	Astrocytic Glutamate-Glutamine Uptake And Metabolism Glutamate and glutamine metabolism	L-Glutamine Glutamic Acid	Congenital systemic glutamine deficiency (CSGD); Glutamine synthetase deficiency
GNMT	glycine N-methyltransferase	Metabolism of ingested SeMet, Sec, MeSec into H2Se Glyoxylate metabolism and glycine degradation	Ademetionine Glycine S-adenosyl-L-homocysteine Citric Acid	Hypermethioninemia; Methionine adenosyltransferase deficiency; S-adenosylhomocysteine hydrolase deficiency
GPBP1	GC-rich promoter binding protein 1
GPBP1L1	GC-rich promoter binding protein 1 like 1
HEY1	hes related family bHLH transcription factor with YRPW motif 1	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants RUNX2 regulates osteoblast differentiation NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription
HSPB7	heat shock protein family B (small) member 7
L3MBTL3	L3MBTL histone methyl-lysine binding protein 3
LDOC1	LDOC1 regulator of NFKB signaling
MAX	MYC associated factor X	Transcription of E2F targets under negative control by DREAM complex Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by E2F6
MBIP	MAP3K12 binding inhibitory protein 1	HATs acetylate histones
MEAF6	MYST/Esa1 associated factor 6	HATs acetylate histones HATs acetylate histones Regulation of TP53 Activity through Acetylation
NKG7	natural killer cell granule protein 7
NONO	non-POU domain containing octamer binding
NPM2	nucleophosmin/nucleoplasmin 2
PDP1	pyruvate dehyrogenase phosphatase catalytic subunit 1	Regulation of pyruvate dehydrogenase (PDH) complex		Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
PEX2	peroxisomal biogenesis factor 2	E3 ubiquitin ligases ubiquitinate target proteins Peroxisomal protein import Peroxisomal protein import Class I peroxisomal membrane protein import		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
PRDM14	PR/SET domain 14	Transcriptional regulation of pluripotent stem cells
PRKAR1A	protein kinase cAMP-dependent type I regulatory subunit alpha	PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production	Sp-Adenosine-3',5'-Cyclic-Monophosphorothioate Cyclic Guanosine Monophosphate Cyclic Adenosine Monophosphate GEM-231	Pigmented micronodular adrenocortical disease (PPNAD)
PRPSAP1	phosphoribosyl pyrophosphate synthetase associated protein 1
RAB39A	RAB39A, member RAS oncogene family	Intra-Golgi traffic RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
RABAC1	Rab acceptor 1
RADX	RPA1 related single stranded DNA binding protein, X-linked
RSPO2	R-spondin 2	Regulation of FZD by ubiquitination
RTN1	reticulon 1
RTN3	reticulon 3	Synaptic adhesion-like molecules
RTN4	reticulon 4	Axonal growth inhibition (RHOA activation)
S100A1	S100 calcium binding protein A1	Regulation of TLR by endogenous ligand	Olopatadine
S100A13	S100 calcium binding protein A13		Olopatadine Amlexanox Calcium Chloride Calcium Calcium Citrate Calcium Phosphate
SEPTIN2	septin 2	Anchoring of the basal body to the plasma membrane
SEPTIN5	septin 5
SEPTIN6	septin 6
SETBP1	SET binding protein 1			Schinzel-Giedion midface retraction syndrome
SFN	stratifin	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Regulation of localization of FOXO transcription factors
SPEF1	sperm flagellar 1
TBX3	T-box transcription factor 3			Ulnar-mammary syndrome; Schinzel syndrome
TCN2	transcobalamin 2	Cobalamin (Cbl, vitamin B12) transport and metabolism Defective TCN2 causes hereditary megaloblastic anemia Defective CD320 causes methylmalonic aciduria
TNFAIP8	TNF alpha induced protein 8	PI Metabolism
TRAF6	TNF receptor associated factor 6	PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment Regulated proteolysis of p75NTR Downstream TCR signaling NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 CLEC7A (Dectin-1) signaling Ub-specific processing proteases Ovarian tumor domain proteases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation MyD88 dependent cascade initiated on endosome IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation MyD88 cascade initiated on plasma membrane
TRAPPC3	trafficking protein particle complex 3	COPII-mediated vesicle transport RAB GEFs exchange GTP for GDP on RABs	Palmitic Acid Myristic acid S-PALMITOYL-L-CYSTEINE
TSC22D3	TSC22 domain family member 3	Stimuli-sensing channels
TXNL4B	thioredoxin like 4B
UBE2Z	ubiquitin conjugating enzyme E2 Z	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
USF1	upstream transcription factor 1	Estrogen-dependent gene expression		Familial combined hyperlipidemia (FCHL)
ZNF250	zinc finger protein 250	Generic Transcription Pathway
ZNF263	zinc finger protein 263	Generic Transcription Pathway
ZNF398	zinc finger protein 398	Generic Transcription Pathway

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