GIGYF2 - Wiki-CORONA

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
APC	APC regulator of WNT signaling pathway	Apoptotic cleavage of cellular proteins Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Deactivation of the beta-catenin transactivating complex Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Misspliced GSK3beta mutants stabilize beta-catenin S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants are not K63 polyubiquitinated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Ovarian tumor domain proteases		Familial adenomatous polyposis Esophageal cancer Gastric cancer Cancer of the anal canal Gallbladder cancer
ARL4C	ADP ribosylation factor like GTPase 4C	NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
ATG16L1	autophagy related 16 like 1	Macroautophagy Macroautophagy		Crohn's disease
CAB39	calcium binding protein 39	Energy dependent regulation of mTOR by LKB1-AMPK Neutrophil degranulation
CNOT9	CCR4-NOT transcription complex subunit 9	Deadenylation of mRNA Activation of anterior HOX genes in hindbrain development during early embryogenesis TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
EPHA2	EPH receptor A2	EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells	Dasatinib Phosphoaminophosphonic Acid-Adenylate Ester Regorafenib
GRB10	growth factor receptor bound protein 10	Signaling by SCF-KIT IRS activation Signal attenuation Insulin receptor signalling cascade RET signaling Response of EIF2AK1 (HRI) to heme deficiency
GRB14	growth factor receptor bound protein 14	Tie2 Signaling
GRB7	growth factor receptor bound protein 7	GRB7 events in ERBB2 signaling Signaling by SCF-KIT Downstream signal transduction Tie2 Signaling RET signaling
METTL21A	methyltransferase like 21A	Protein methylation
NMUR1	neuromedin U receptor 1	Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
RBM12	RNA binding motif protein 12
SNRPB	small nuclear ribonucleoprotein polypeptides B and B1	SLBP independent Processing of Histone Pre-mRNAs snRNP Assembly mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
WBP11	WW domain binding protein 11	mRNA Splicing - Major Pathway

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