DCAF7 - Wiki-CORONA

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
ACE	angiotensin I converting enzyme	Metabolism of Angiotensinogen to Angiotensins	Ramipril Fosinopril Trandolapril Benazepril Enalapril Candoxatril Moexipril Lisinopril Perindopril Quinapril Omapatrilat Rescinnamine Captopril Cilazapril Spirapril 1-(3-Mercapto-2-Methyl-Propionyl)-Pyrrolidine-2-Carboxylic Acid N-acetyl-alpha-D-glucosamine Temocapril Enalaprilat Zofenopril	Renal tubular dysgenesis Allograft rejection
AIFM1	apoptosis inducing factor mitochondria associated 1		Flavin adenine dinucleotide MCC	Combined oxidative phosphorylation deficiency (COXPD)
APP	amyloid beta precursor protein	Platelet degranulation ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (q) signalling events G alpha (i) signalling events Lysosome Vesicle Biogenesis Formyl peptide receptors bind formyl peptides and many other ligands TAK1 activates NFkB by phosphorylation and activation of IKKs complex The NLRP3 inflammasome Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Post-translational protein phosphorylation TRAF6 mediated NF-kB activation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Purinergic signaling in leishmaniasis infection Amyloid fiber formation	Deferoxamine Aluminium Zinc L-methionine (R)-S-oxide Resveratrol Phenserine Tiomolibdate ion CAD106 Mito-4509 Dimercaprol Copper Florbetaben (18F) Florbetapir (18F) Flutemetamol (18F)	Alzheimer's disease (AD)
ATP13A2	ATPase cation transporting 13A2	Ion transport by P-type ATPases		Parkinson's disease (PD)
ATP5PD	ATP synthase peripheral stalk subunit d	Formation of ATP by chemiosmotic coupling Cristae formation
BMPR1B	bone morphogenetic protein receptor type 1B	Signaling by BMP		Acromesomelic dysplasia with genital anomalies Brachydactyly, including: type A; type B; type D; type E
CBX1	chromobox 1	HCMV Early Events
DYRK1B	dual specificity tyrosine phosphorylation regulated kinase 1B
LIG1	DNA ligase 1	POLB-Dependent Long Patch Base Excision Repair Early Phase of HIV Life Cycle Processive synthesis on the C-strand of the telomere Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Gap-filling DNA repair synthesis and ligation in GG-NER Gap-filling DNA repair synthesis and ligation in TC-NER Processive synthesis on the lagging strand	Bleomycin	DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
PCTP	phosphatidylcholine transfer protein	Synthesis of PC Mitochondrial Fatty Acid Beta-Oxidation	Palmitoyl-Linoleoyl Phosphatidylcholine Di-Linoleoyl-3-Sn-Phosphatidylcholine
PWP2	PWP2 small subunit processome component	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
SPDYA	speedy/RINGO cell cycle regulator family member A
TANC2	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TK1	thymidine kinase 1	G1/S-Specific Transcription Pyrimidine salvage	Dithioerythritol Thymidine-5'-Triphosphate
TLK2	tousled like kinase 2
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane mTOR signalling mTORC1-mediated signalling Frs2-mediated activation Frs2-mediated activation ARMS-mediated activation Signaling by Hippo Rap1 signalling Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA RHO GTPases activate PKNs TP53 Regulates Metabolic Genes RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Regulation of localization of FOXO transcription factors Signaling downstream of RAS mutants	Copper Phenethyl Isothiocyanate
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex AURKA Activation by TPX2 Regulation of localization of FOXO transcription factors

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