COMT - Wiki-CORONA

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
ACE	angiotensin I converting enzyme	Metabolism of Angiotensinogen to Angiotensins	Ramipril Fosinopril Trandolapril Benazepril Enalapril Candoxatril Moexipril Lisinopril Perindopril Quinapril Omapatrilat Rescinnamine Captopril Cilazapril Spirapril 1-(3-Mercapto-2-Methyl-Propionyl)-Pyrrolidine-2-Carboxylic Acid N-acetyl-alpha-D-glucosamine Temocapril Enalaprilat Zofenopril	Renal tubular dysgenesis Allograft rejection
BRS3	bombesin receptor subtype 3	Peptide ligand-binding receptors G alpha (q) signalling events
CDC27	cell division cycle 27	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Antigen processing: Ubiquitination & Proteasome degradation
GLP1R	glucagon like peptide 1 receptor	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production	Glucagon recombinant Exenatide Liraglutide Albiglutide Dulaglutide Lixisenatide Semaglutide
HCK	HCK proto-oncogene, Src family tyrosine kinase	Nef and signal transduction FCGR activation Regulation of signaling by CBL Regulation of signaling by CBL FLT3 Signaling FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis	1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Phosphonotyrosine Quercetin Bosutinib
HOPX	HOP homeobox
KRT31	keratin 31	Keratinization Formation of the cornified envelope
KRT40	keratin 40	Keratinization Formation of the cornified envelope
KRTAP5-9	keratin associated protein 5-9	Keratinization
LITAF	lipopolysaccharide induced TNF factor			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
MRPS5	mitochondrial ribosomal protein S5	Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination
MTNR1A	melatonin receptor 1A	Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events	Ramelteon Melatonin Resveratrol Agomelatine Tasimelteon
RGS2	regulator of G protein signaling 2	G alpha (q) signalling events
TRIP13	thyroid hormone receptor interactor 13
VKORC1	vitamin K epoxide reductase complex subunit 1	Metabolism of vitamin K	Menadione Dicoumarol Phenindione Warfarin Phenprocoumon Acenocoumarol	Combined deficiency of vitamin K-dependent clotting factors (VKCFD)
XRN2	5'-3' exoribonuclease 2	Association of TriC/CCT with target proteins during biosynthesis Major pathway of rRNA processing in the nucleolus and cytosol
ZNF43	zinc finger protein 43	Generic Transcription Pathway

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