CHPF - Wiki-CORONA

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
ARHGEF5	Rho guanine nucleotide exchange factor 5	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
ATG9A	autophagy related 9A	Macroautophagy
BTRC	beta-transducin repeat containing E3 ubiquitin protein ligase	Activation of NF-kappaB in B cells Prolactin receptor signaling SCF-beta-TrCP mediated degradation of Emi1 Vpu mediated degradation of CD4 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Deactivation of the beta-catenin transactivating complex Circadian Clock Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome NIK - noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Neddylation Interleukin-1 signaling Antigen processing: Ubiquitination & Proteasome degradation
CERS5	ceramide synthase 5	Sphingolipid de novo biosynthesis
EXOSC10	exosome component 10	Major pathway of rRNA processing in the nucleolus and cytosol
EXOSC6	exosome component 6	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
GLB1L	galactosidase beta 1 like	Glycosphingolipid metabolism Keratan sulfate degradation HS-GAG degradation
ITGB2	integrin subunit beta 2	Toll Like Receptor 4 (TLR4) Cascade Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Integrin cell surface interactions Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation	Simvastatin	Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency
LINC00839	long intergenic non-protein coding RNA 839
NKX3-1	NK3 homeobox 1			Prostate cancer
NPBWR2	neuropeptides B and W receptor 2	Peptide ligand-binding receptors G alpha (i) signalling events
PIN1	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	ISG15 antiviral mechanism RHO GTPases Activate NADPH Oxidases Regulation of TP53 Activity through Phosphorylation PI5P Regulates TP53 Acetylation Negative regulators of DDX58/IFIH1 signaling	Beta-(2-Naphthyl)-Alanine 3,6,9,12,15,18-HEXAOXAICOSANE
PRKN	parkin RBR E3 ubiquitin protein ligase	Pink/Parkin Mediated Mitophagy Josephin domain DUBs Aggrephagy Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation		Parkinson's disease (PD)
RAC2	Rac family small GTPase 2	GPVI-mediated activation cascade ROS and RNS production in phagocytes PIP3 activates AKT signaling Rho GTPase cycle Constitutive Signaling by Aberrant PI3K in Cancer PCP/CE pathway RHO GTPases Activate NADPH Oxidases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Dextromethorphan	Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency
RNF25	ring finger protein 25	Antigen processing: Ubiquitination & Proteasome degradation
SKIL	SKI like proto-oncogene	Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD9	SMAD family member 9	Signaling by BMP
TUBA4B	tubulin alpha 4b

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