CDK5RAP2 - Wiki-CORONA

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
ABCA2	ATP binding cassette subfamily A member 2	ABC transporters in lipid homeostasis
CDK5	cyclin dependent kinase 5	DARPP-32 events CRMPs in Sema3A signaling CRMPs in Sema3A signaling Regulation of TP53 Activity through Phosphorylation Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models NGF-stimulated transcription Activated NTRK2 signals through CDK5 Factors involved in megakaryocyte development and platelet production	Indirubin-3'-Monoxime Olomoucine Hymenialdisine SU9516 Alvocidib Alsterpaullone 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
CDK5R1	cyclin dependent kinase 5 regulatory subunit 1	CRMPs in Sema3A signaling CRMPs in Sema3A signaling Regulation of TP53 Activity through Phosphorylation Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models NGF-stimulated transcription NGF-stimulated transcription Activated NTRK2 signals through CDK5	Indirubin-3'-Monoxime 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
CRMP1	collapsin response mediator protein 1	CRMPs in Sema3A signaling
EEF1G	eukaryotic translation elongation factor 1 gamma	Eukaryotic Translation Elongation
ERG28	ergosterol biosynthesis 28 homolog
FBXO25	F-box protein 25
HAP1	huntingtin associated protein 1
KAT5	lysine acetyltransferase 5	Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex DNA Damage/Telomere Stress Induced Senescence HATs acetylate histones HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Estrogen-dependent gene expression	Coenzyme A S-Acetyl-Cysteine
LUC7L2	LUC7 like 2, pre-mRNA splicing factor
MAGEH1	MAGE family member H1
MAPRE1	microtubule associated protein RP/EB family member 1	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
MRRF	mitochondrial ribosome recycling factor	Mitochondrial translation termination
NEFL	neurofilament light	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
PCBD1	pterin-4 alpha-carbinolamine dehydratase 1	Phenylalanine metabolism	L-erythro-7,8-dihydrobiopterin	Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
PHF19	PHD finger protein 19	PRC2 methylates histones and DNA
PTN	pleiotrophin
RBM48	RNA binding motif protein 48
REPS2	RALBP1 associated Eps domain containing 2	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
SENP2	SUMO specific peptidase 2	SUMO is proteolytically processed
STARD9	StAR related lipid transfer domain containing 9
STK36	serine/threonine kinase 36
TBC1D4	TBC1 domain family member 4	Translocation of SLC2A4 (GLUT4) to the plasma membrane
TRIM37	tripartite motif containing 37	Antigen processing: Ubiquitination & Proteasome degradation
TSNAX	translin associated factor X	Small interfering RNA (siRNA) biogenesis
ZPR1	ZPR1 zinc finger

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