Pulmonary - Wiki-CORONA

Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide	Diseases 1 Hide	Diseases 2 Hide
ABCA1 and PDZK1	ATP binding cassette subfamily A member 1	PDZ domain containing 1	PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux		ATP Glyburide Probucol		Tangier disease Hypoalphalipoproteinemia
ABCA1 and LIN7C	ATP binding cassette subfamily A member 1	lin-7 homolog C, crumbs cell polarity complex component	PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Dopamine Neurotransmitter Release Cycle Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors	ATP Glyburide Probucol		Tangier disease Hypoalphalipoproteinemia
ABCA1 and AOX1	ATP binding cassette subfamily A member 1	aldehyde oxidase 1	PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Vitamins B6 activation to pyridoxal phosphate	ATP Glyburide Probucol	Eniluracil	Tangier disease Hypoalphalipoproteinemia	Xanthinuria
ABCA1 and SPTLC1	ATP binding cassette subfamily A member 1	serine palmitoyltransferase long chain base subunit 1	PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Sphingolipid de novo biosynthesis	ATP Glyburide Probucol	Pyridoxal Phosphate Serine	Tangier disease Hypoalphalipoproteinemia
ABCA1 and UGP2	ATP binding cassette subfamily A member 1	UDP-glucose pyrophosphorylase 2	PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Formation of the active cofactor, UDP-glucuronate Glycogen synthesis	ATP Glyburide Probucol		Tangier disease Hypoalphalipoproteinemia
ABCA1 and SLC25A34	ATP binding cassette subfamily A member 1	solute carrier family 25 member 34	PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux		ATP Glyburide Probucol		Tangier disease Hypoalphalipoproteinemia
ABCA1 and FADD	ATP binding cassette subfamily A member 1	Fas associated via death domain	PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Caspase activation via Death Receptors in the presence of ligand TRIF-mediated programmed cell death Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Dimerization of procaspase-8 FasL/ CD95L signaling TRAIL signaling TLR3-mediated TICAM1-dependent programmed cell death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	ATP Glyburide Probucol		Tangier disease Hypoalphalipoproteinemia
ABCA1 and IKBKG	ATP binding cassette subfamily A member 1	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells ER-Phagosome pathway NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 Downstream TCR signaling FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 SUMOylation of immune response proteins Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway IKBKB deficiency causes SCID IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Ub-specific processing proteases Ovarian tumor domain proteases Interleukin-1 signaling TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	ATP Glyburide Probucol	AGRO100 Tarenflurbil	Tangier disease Hypoalphalipoproteinemia	Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases: NF-kappa-B essential modulator (NEMO) defect; Inhibitor of kappa-B (I-kappa-B) defect Incontinentia pigmenti Osteoporosis, lymphedema, anhydrotic ectodermal dysplasia with immunodeficiency (OLEDAID); Ectodermal dysplasia, anhidrotic, with immunodeficiency, osteopetrosis, and lymphedema
ABCA1 and MPDZ	ATP binding cassette subfamily A member 1	multiple PDZ domain crumbs cell polarity complex component	PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux		ATP Glyburide Probucol		Tangier disease Hypoalphalipoproteinemia
ABCA1 and DLG3	ATP binding cassette subfamily A member 1	discs large MAGUK scaffold protein 3	PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	ATP Glyburide Probucol		Tangier disease Hypoalphalipoproteinemia	Non-syndromic X-linked mental retardation
ABCA1 and APOA1	ATP binding cassette subfamily A member 1	apolipoprotein A1	PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Platelet degranulation ABC transporters in lipid homeostasis PPARA activates gene expression Scavenging of heme from plasma Scavenging by Class B Receptors Scavenging by Class B Receptors Scavenging by Class A Receptors Scavenging by Class A Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Defective ABCA1 causes Tangier disease Post-translational protein phosphorylation Chylomicron assembly HDL assembly Chylomicron remodeling HDL clearance HDL remodeling Retinoid metabolism and transport Retinoid metabolism and transport Amyloid fiber formation	ATP Glyburide Probucol	Zinc Copper	Tangier disease Hypoalphalipoproteinemia	Hypoalphalipoproteinemia Familial amyloidosis
ABCA1 and TRIM27	ATP binding cassette subfamily A member 1	tripartite motif containing 27	PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	SUMOylation of ubiquitinylation proteins Regulation of PTEN stability and activity Suppression of apoptosis	ATP Glyburide Probucol		Tangier disease Hypoalphalipoproteinemia
ABCA1 and ATXN10	ATP binding cassette subfamily A member 1	ataxin 10	PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux		ATP Glyburide Probucol		Tangier disease Hypoalphalipoproteinemia
ABCA1 and LIN7A	ATP binding cassette subfamily A member 1	lin-7 homolog A, crumbs cell polarity complex component	PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Dopamine Neurotransmitter Release Cycle Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors	ATP Glyburide Probucol		Tangier disease Hypoalphalipoproteinemia
ABCA1 and MPP6	ATP binding cassette subfamily A member 1	membrane palmitoylated protein 6	PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux		ATP Glyburide Probucol		Tangier disease Hypoalphalipoproteinemia
ABCA1 and PRPF8	ATP binding cassette subfamily A member 1	pre-mRNA processing factor 8	PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway	ATP Glyburide Probucol		Tangier disease Hypoalphalipoproteinemia	Retinitis pigmentosa (RP)
ABCA1 and LNX1	ATP binding cassette subfamily A member 1	ligand of numb-protein X 1	PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Antigen processing: Ubiquitination & Proteasome degradation	ATP Glyburide Probucol		Tangier disease Hypoalphalipoproteinemia
ABCA1 and ERBIN	ATP binding cassette subfamily A member 1	erbb2 interacting protein	PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Signaling by ERBB2 Downregulation of ERBB2 signaling Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants	ATP Glyburide Probucol		Tangier disease Hypoalphalipoproteinemia
ABCA1 and PLTP	ATP binding cassette subfamily A member 1	phospholipid transfer protein	PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux		ATP Glyburide Probucol		Tangier disease Hypoalphalipoproteinemia
ABCA1 and SNTB1	ATP binding cassette subfamily A member 1	syntrophin beta 1	PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux		ATP Glyburide Probucol		Tangier disease Hypoalphalipoproteinemia

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