Pulmonary - Wiki-CORONA

Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide	Diseases 1 Hide
A2M and NOS3	alpha-2-macroglobulin	nitric oxide synthase 3	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Degradation of the extracellular matrix Rho GTPase cycle HDL assembly	ROS and RNS production in phagocytes Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation eNOS activation NOSTRIN mediated eNOS trafficking NOSIP mediated eNOS trafficking Nitric oxide stimulates guanylate cyclase VEGFR2 mediated vascular permeability Extra-nuclear estrogen signaling	Becaplermin Cisplatin Bacitracin Zinc Ocriplasmin	L-Arginine L-Citrulline Sapropterin Miconazole N,N-dimethylarginine L-N(Omega)-Nitroarginine-2,4-L-Diaminobutyric Amide L-2-Amino-4-(Guanidinooxy)Butyric Acid 3-Bromo-7-Nitroindazole N-{(4s)-4-Amino-5-[(2-Aminoethyl)Amino]Pentyl}-N'-Nitroguanidine N-(3-(Aminomethyl)Benzyl)Acetamidine 1,2,4-Triazole-Carboxamidine L-N(Omega)-Nitroarginine-(4r)-Amino-L-Proline Amide S,S'-(1,4-Phenylene-Bis(1,2-Ethanediyl))Bis-Isothiourea 7-Nitroindazole S-Ethylisothiourea 2-Aminothiazoline Se-Ethyl-Isoselenourea 2,4-Diamino-6-Phenyl-5,6,7,8,-Tetrahydropteridine N1,N14-Bis((S-Methyl)Isothioureido)Tetradecane Cacodylic acid 7-Nitroindazole-2-Carboxamidine 6-Nitroindazole N-Omega-Hydroxy-L-Arginine N5-Iminoethyl-L-Ornithine 5,6-Cyclic-Tetrahydropteridine S-Ethyl-N-Phenyl-Isothiourea S,S'-(1,3-Phenylene-Bis(1,2-Ethanediyl))Bis-Isothiourea 6S-5,6,7,8-Tetrahydrobiopterin S-(Dimethylarsenic)Cysteine L-Homoarginine S-Isopropyl-Isothiourea Nitroarginine 5-Nitroindazole N-(Chlorophenyl)-N'-Hydroxyguanidine Apremilast (3S,5E)-3-propyl-3,4-dihydrothieno[2,3-f][1,4]oxazepin-5(2H)-imine 5-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamine
A2M and EGLN2	alpha-2-macroglobulin	egl-9 family hypoxia inducible factor 2	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Degradation of the extracellular matrix Rho GTPase cycle HDL assembly	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	Becaplermin Cisplatin Bacitracin Zinc Ocriplasmin	Vitamin C Roxadustat
A2M and LRP1	alpha-2-macroglobulin	LDL receptor related protein 1	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Degradation of the extracellular matrix Rho GTPase cycle HDL assembly	Scavenging of heme from plasma Retinoid metabolism and transport	Becaplermin Cisplatin Bacitracin Zinc Ocriplasmin	Antihemophilic factor, human recombinant Tenecteplase Coagulation Factor IX (Recombinant) Coagulation Factor IX Human
SERPINA3 and CTRB1	serpin family A member 3	chymotrypsinogen B1	Platelet degranulation Neutrophil degranulation	Activation of Matrix Metalloproteinases Cobalamin (Cbl, vitamin B12) transport and metabolism	Zinc	Trans-O-Hydroxy-Alpha-Methyl Cinnamate 2,4-Dihydroxy-Trans Cinnamic Acid Phenylethane Boronic Acid Phosphorylisopropane Aprotinin 1,1,1-TRIFLUORO-3-ACETAMIDO-4-PHENYL BUTAN-2-ONE(N-ACETYL-L-PHENYLALANYL TRIFLUOROMETHYL KETONE) N-(1-BENZYL-3,3,3-TRIFLUORO-2,2-DIHYDROXY-PROPYL)-ACETAMIDE 3-(4-DIETHYLAMINO-2-HYDROXY-PHENYL)-2-METHYL-PROPIONIC ACID 2-ACETYLAMINO-4-METHYL-PENTANOIC ACID (1-FORMYL-2-PHENYL-ETHYL)-AMIDE (2S) N-acetyl-L-alanyl-Î±L-phenylalanyl-chloroethylketone 1,1,1-TRIFLUORO-3-((N-ACETYL)-L-LEUCYLAMIDO)-4-PHENYL-BUTAN-2-ONE(N-ACETYL-L-LEUCYL-L-PHENYLALANYL TRIFLUOROMETHYL KETONE) (3S)-3-Amino-1-chloro-4-phenyl-2-butanone L-1-naphthyl-2-acetamido-ethane boronic acid D-1-naphthyl-2-acetamido-ethane boronic acid D-1-(4-chlorophenyl)-2-(acetamido)ethane boronic acid L-1-(4-chlorophenyl)-2-(acetamido)ethane boronic acid
ABCA1 and SHANK1	ATP binding cassette subfamily A member 1	SH3 and multiple ankyrin repeat domains 1	PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Neurexins and neuroligins Neurexins and neuroligins	ATP Glyburide Probucol		Tangier disease Hypoalphalipoproteinemia
ABCA1 and LIN7B	ATP binding cassette subfamily A member 1	lin-7 homolog B, crumbs cell polarity complex component	PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Dopamine Neurotransmitter Release Cycle RHO GTPases Activate Rhotekin and Rhophilins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors	ATP Glyburide Probucol		Tangier disease Hypoalphalipoproteinemia
ABCA1 and PDLIM3	ATP binding cassette subfamily A member 1	PDZ and LIM domain 3	PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux		ATP Glyburide Probucol		Tangier disease Hypoalphalipoproteinemia
ABCA1 and TGM2	ATP binding cassette subfamily A member 1	transglutaminase 2	PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux		ATP Glyburide Probucol	Guanosine-5'-Diphosphate	Tangier disease Hypoalphalipoproteinemia
ABCA1 and DLG5	ATP binding cassette subfamily A member 1	discs large MAGUK scaffold protein 5	PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux		ATP Glyburide Probucol		Tangier disease Hypoalphalipoproteinemia
ABCA1 and LIMK1	ATP binding cassette subfamily A member 1	LIM domain kinase 1	PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling Sema3A PAK dependent Axon repulsion Sema3A PAK dependent Axon repulsion Sema4D induced cell migration and growth-cone collapse RHO GTPases Activate ROCKs RHO GTPases activate PAKs	ATP Glyburide Probucol	Dabrafenib	Tangier disease Hypoalphalipoproteinemia
ABCA1 and RIMS2	ATP binding cassette subfamily A member 1	regulating synaptic membrane exocytosis 2	PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux		ATP Glyburide Probucol		Tangier disease Hypoalphalipoproteinemia
ABCA1 and RAPGEF6	ATP binding cassette subfamily A member 1	Rap guanine nucleotide exchange factor 6	PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux		ATP Glyburide Probucol		Tangier disease Hypoalphalipoproteinemia
ABCA1 and ARHGEF12	ATP binding cassette subfamily A member 1	Rho guanine nucleotide exchange factor 12	PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse	ATP Glyburide Probucol		Tangier disease Hypoalphalipoproteinemia
ABCA1 and GOPC	ATP binding cassette subfamily A member 1	golgi associated PDZ and coiled-coil motif containing	PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	RHO GTPases regulate CFTR trafficking	ATP Glyburide Probucol		Tangier disease Hypoalphalipoproteinemia
ABCA1 and SNTA1	ATP binding cassette subfamily A member 1	syntrophin alpha 1	PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux		ATP Glyburide Probucol		Tangier disease Hypoalphalipoproteinemia
ABCA1 and TIAM1	ATP binding cassette subfamily A member 1	TIAM Rac1 associated GEF 1	PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	NRAGE signals death through JNK Rho GTPase cycle EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells G alpha (12/13) signalling events Activated NTRK2 signals through CDK5	ATP Glyburide Probucol		Tangier disease Hypoalphalipoproteinemia
ABCA1 and LMO7	ATP binding cassette subfamily A member 1	LIM domain 7	PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Neddylation Antigen processing: Ubiquitination & Proteasome degradation	ATP Glyburide Probucol		Tangier disease Hypoalphalipoproteinemia
ABCA1 and CSNK2A1	ATP binding cassette subfamily A member 1	casein kinase 2 alpha 1	PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Synthesis of PC WNT mediated activation of DVL Condensation of Prometaphase Chromosomes Signal transduction by L1 Regulation of TP53 Activity through Phosphorylation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Receptor Mediated Mitophagy RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN stability and activity	ATP Glyburide Probucol	ATP (5-Oxo-5,6-Dihydro-Indolo[1,2-a]Quinazolin-7-Yl)-Acetic Acid 1,8-Di-Hydroxy-4-Nitro-Xanthen-9-One Resveratrol 1,8-Di-Hydroxy-4-Nitro-Anthraquinone Benzamidine 5,8-Di-Amino-1,4-Dihydroxy-Anthraquinone Quercetin Phosphoaminophosphonic Acid-Adenylate Ester Tetrabromo-2-Benzotriazole DIMETHYL-(4,5,6,7-TETRABROMO-1H-BENZOIMIDAZOL-2-YL)-AMINE S-METHYL-4,5,6,7-TETRABROMO-BENZIMIDAZOLE N1,N2-ETHYLENE-2-METHYLAMINO-4,5,6,7-TETRABROMO-BENZIMIDAZOLE Emodin 3,8-DIBROMO-7-HYDROXY-4-METHYL-2H-CHROMEN-2-ONE 19-(cyclopropylamino)-4,6,7,15-tetrahydro-5H-16,1-(azenometheno)-10,14-(metheno)pyrazolo[4,3-o][1,3,9]triazacyclohexadecin-8(9H)-one N,N'-DIPHENYLPYRAZOLO[1,5-A][1,3,5]TRIAZINE-2,4-DIAMINE 4-(2-(1H-IMIDAZOL-4-YL)ETHYLAMINO)-2-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE 2-(CYCLOHEXYLMETHYLAMINO)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE 2-(4-CHLOROBENZYLAMINO)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE 2-(4-ETHYLPIPERAZIN-1-YL)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE N-(3-(8-CYANO-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZIN-2-YLAMINO)PHENYL)ACETAMIDE 5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole 1,2,5,8-tetrahydroxyanthracene-9,10-dione Ellagic Acid	Tangier disease Hypoalphalipoproteinemia
ABCA1 and CSNK2A2	ATP binding cassette subfamily A member 1	casein kinase 2 alpha 2	PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Synthesis of PC WNT mediated activation of DVL Condensation of Prometaphase Chromosomes Signal transduction by L1 Regulation of TP53 Activity through Phosphorylation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Receptor Mediated Mitophagy RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN stability and activity	ATP Glyburide Probucol	[1-(6-{6-[(1-methylethyl)amino]-1H-indazol-1-yl}pyrazin-2-yl)-1H-pyrrol-3-yl]acetic acid	Tangier disease Hypoalphalipoproteinemia
ABCA1 and ARHGEF11	ATP binding cassette subfamily A member 1	Rho guanine nucleotide exchange factor 11	PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse	ATP Glyburide Probucol		Tangier disease Hypoalphalipoproteinemia

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