AIM2

Description		absent in melanoma 2
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol AIM2 Inflammasome Complex
	Molecular Function	Double-stranded DNA Binding Protein Binding Identical Protein Binding
	Biological Process	Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Apoptotic Process Inflammatory Response Immune Response Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Interleukin-1 Beta Production Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Interferon-beta Cellular Response To Drug NLRP3 Inflammasome Complex Assembly Innate Immune Response Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of NF-kappaB Transcription Factor Activity Pyroptosis Pyroptosome Complex Assembly Positive Regulation Of Cysteine-type Endopeptidase Activity
Pathways		The AIM2 inflammasome The AIM2 inflammasome
Drugs
Diseases
GWAS		Neutrophil count in HIV-infection ( 25884002) Obesity-related traits ( 23251661) Psoriasis ( 25854761)
Interacting Genes		1 interacting genes: APPBP2
Entrez ID		9447
HPRD ID		05202
Ensembl ID		ENSG00000163568
Uniprot IDs		O14862
PDB IDs		3RN2 3RN5 3VD8 4O7Q 6MB2
Enriched GO Terms of Interacting Partners?
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