DGKI

Description		diacylglycerol kinase iota
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Synaptic Vesicle Guanyl-nucleotide Exchange Factor Complex Protein-containing Complex Neuronal Cell Body Dendritic Spine Axon Terminus Synapse Perinuclear Region Of Cytoplasm Excitatory Synapse Schaffer Collateral - CA1 Synapse Extrinsic Component Of Presynaptic Active Zone Membrane Glutamatergic Synapse Extrinsic Component Of Postsynaptic Density Membrane
	Molecular Function	NAD+ Kinase Activity Diacylglycerol Kinase Activity GTPase Inhibitor Activity Protein Binding ATP Binding Ras GTPase Binding Metal Ion Binding
	Biological Process	Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Neurotransmitter Secretion Platelet Activation Negative Regulation Of GTPase Activity Intracellular Signal Transduction Diacylglycerol Metabolic Process Glycerolipid Metabolic Process Positive Regulation Of Ras Protein Signal Transduction Lipid Phosphorylation Habituation Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Regulation Of Long-term Synaptic Depression Regulation Of Synaptic Vesicle Exocytosis
Pathways		Effects of PIP2 hydrolysis
Drugs
Diseases
GWAS		Adventurousness ( 30643258) AIDS progression ( 21502085) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26865924) Cognitive decline (age-related) ( 24468470) General risk tolerance (MTAG) ( 30643258) Lean body mass ( 28552196) Schizophrenia ( 28991256 25056061 29483656 30285260) Testosterone levels in polycystic ovary syndrome ( 26284813)
Interacting Genes		2 interacting genes: RAB5C VHL
Entrez ID		9162
HPRD ID		07238
Ensembl ID		ENSG00000157680
Uniprot IDs		E7EWQ4 E9PFX6 O75912 Q59GE2
PDB IDs
Enriched GO Terms of Interacting Partners?
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