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CCNE2

Description cyclin E2
Image No pdb structure
GO Annotations Cellular Component
  • Cyclin-dependent Protein Kinase Holoenzyme Complex
  • Nucleus
  • Nucleoplasm
  • Cytoplasm
  • Centrosome
  • Cytosol
  • Cyclin E1-CDK2 Complex
  • Cyclin E2-CDK2 Complex
Molecular Function
  • Protein Kinase Activity
  • Protein Binding
  • Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
  • Protein Kinase Binding
Biological Process
  • Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
  • G1/S Transition Of Mitotic Cell Cycle
  • Telomere Maintenance
  • DNA Replication Initiation
  • Protein Phosphorylation
  • Synapsis
  • Mitotic Cell Cycle Phase Transition
  • Cell Division
  • Regulation Of Cellular Protein Localization
Pathways
  • G0 and Early G1
  • SCF(Skp2)-mediated degradation of p27/p21
  • DNA Damage/Telomere Stress Induced Senescence
  • Association of TriC/CCT with target proteins during biosynthesis
  • TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
  • CDK-mediated phosphorylation and removal of Cdc6
  • Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
  • Cyclin E associated events during G1/S transition
  • p53-Dependent G1 DNA Damage Response
Drugs
Diseases
  • Laryngeal cancer
  • Gastric cancer
GWAS
Interacting Genes 12 interacting genes: APP CDK2 CDK3 CDKN1A CDKN1B CDKN1C FBXO7 FBXW7 ORC3 SUMO2 SUMO3 ZDHHC17
Entrez ID 9134
HPRD ID 04801
Ensembl ID ENSG00000175305
Uniprot IDs A0A024R9B0 O96020
PDB IDs
Enriched GO Terms of Interacting Partners?
Tagcloud ?

© Madhavi K. Ganapathiraju 2012-2025

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