ACTN3

Description		actinin alpha 3 (gene/pseudogene)
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GO Annotations	Cellular Component	Cytosol Actin Filament Focal Adhesion Pseudopodium Extracellular Exosome
	Molecular Function	Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Ion Channel Binding
	Biological Process	Regulation Of The Force Of Skeletal Muscle Contraction Skeletal Muscle Atrophy Transition Between Fast And Slow Fiber Response To Denervation Involved In Regulation Of Muscle Adaptation Muscle Filament Sliding Regulation Of Apoptotic Process Negative Regulation Of Glycolytic Process Focal Adhesion Assembly Positive Regulation Of Skeletal Muscle Tissue Growth Negative Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Oxidative Phosphorylation Negative Regulation Of Cold-induced Thermogenesis Regulation Of Aerobic Respiration Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate
Pathways		Nephrin family interactions Striated Muscle Contraction
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972) Frontotemporal dementia with GRN mutation ( 29724592)
Interacting Genes		17 interacting genes: ABI3 ACTN1 ACTN2 ACTN4 ADORA2A BRCA1 C1orf94 KCTD6 MYPN NEBL NRAP PLEKHG2 REL RNF111 SUMO1P1 TRAF1 TRAF2
Entrez ID		89
HPRD ID		02148
Ensembl ID		ENSG00000248746
Uniprot IDs		A0A087WSZ2 B4DZQ2 Q08043
PDB IDs		1TJT 1WKU 3LUE
Enriched GO Terms of Interacting Partners?
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