CASR

Description		calcium sensing receptor
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GO Annotations	Cellular Component	Cell Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Neuronal Cell Body Axon Terminus
	Molecular Function	Phosphatidylinositol Phospholipase C Activity G Protein-coupled Receptor Activity Integrin Binding Calcium Ion Binding Protein Binding Amino Acid Binding Protein Kinase Binding Signaling Receptor Activity Protein Homodimerization Activity Ion Channel Binding
	Biological Process	Ossification Response To Ischemia Detection Of Calcium Ion Cellular Calcium Ion Homeostasis Apoptotic Process G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway JNK Cascade Chemosensory Behavior Positive Regulation Of Cell Proliferation Anatomical Structure Morphogenesis Positive Regulation Of Gene Expression Positive Regulation Of Insulin Secretion Positive Regulation Of ATPase Activity Bile Acid Secretion Cellular Response To Hepatocyte Growth Factor Stimulus Vasodilation Positive Regulation Of Vasoconstriction Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Positive Chemotaxis Regulation Of Calcium Ion Transport Fat Pad Development Positive Regulation Of ERK1 And ERK2 Cascade Calcium Ion Import Cellular Response To Vitamin D Cellular Response To Glucose Stimulus Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Hypoxia Response To Fibroblast Growth Factor Positive Regulation Of Calcium Ion Import Cellular Response To Peptide Chloride Transmembrane Transport
Pathways		G alpha (q) signalling events G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs		Spermine Neomycin Cinacalcet Ronacaleret Calcium Citrate Calcium Phosphate Etelcalcetide
Diseases		Bartter syndrome
GWAS		Calcium levels ( 20661308 25972035 25886283 24068962 29403010 20705733) Cardiac Troponin-T levels ( 23247143) Clinical laboratory measurements ( 27897004) Kidney stones ( 26272126) Metabolite levels ( 31628463) Phosphorus levels ( 20558539) Psoriasis ( 25854761) Serum parathyroid hormone levels ( 27927781) Type 2 diabetes ( 30718926)
Interacting Genes		10 interacting genes: FLNA HIF1A NOTCH1 PI4K2B PRKCA PRKCB PRKCG RNF19A STAMBP VHL
Entrez ID		846
HPRD ID		03122
Ensembl ID		ENSG00000036828
Uniprot IDs		P41180
PDB IDs		5FBH 5FBK 5K5S 5K5T
Enriched GO Terms of Interacting Partners?
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