BRIP1

Description		BRCA1 interacting protein C-terminal helicase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Membrane
	Molecular Function	DNA Binding DNA Helicase Activity Chromatin Binding RNA Helicase Activity Protein Binding ATP Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	DNA Damage Checkpoint DNA Replication Nucleotide-excision Repair Double-strand Break Repair Regulation Of Transcription By RNA Polymerase II Spermatogonial Cell Division Spermatid Development Negative Regulation Of Cell Proliferation Response To Toxic Substance Negative Regulation Of Gene Expression Meiotic DNA Double-strand Break Processing Involved In Reciprocal Meiotic Recombination DNA Duplex Unwinding Chiasma Assembly Cellular Response To Vitamin Cellular Response To Hypoxia Seminiferous Tubule Development Regulation Of Signal Transduction By P53 Class Mediator Cellular Response To Angiotensin Double-strand Break Repair Involved In Meiotic Recombination
Pathways		Cytosolic iron-sulfur cluster assembly HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases		Fanconi anemia
GWAS		Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Ovarian cancer ( 21964575) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		9 interacting genes: BLM BRCA1 CREBBP FANCD2 HDAC3 HNRNPC RPA1 SIRT1 TOPBP1
Entrez ID		83990
HPRD ID		05797
Ensembl ID		ENSG00000136492
Uniprot IDs		Q9BX63
PDB IDs		1T15 1T29 3AL3
Enriched GO Terms of Interacting Partners?
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