PLA2G6

Description		phospholipase A2 group VI
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cell Mitochondrion Cytosol Membrane Centriolar Satellite
	Molecular Function	Phospholipase A2 Activity Calmodulin Binding Hydrolase Activity Serine Hydrolase Activity Protein Kinase Binding ATP-dependent Protein Binding Calcium-independent Phospholipase A2 Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)
	Biological Process	Positive Regulation Of Protein Phosphorylation Chemotaxis Positive Regulation Of Cytosolic Calcium Ion Concentration Memory Urinary Bladder Smooth Muscle Contraction Lipid Catabolic Process Antibacterial Humoral Response Cardiolipin Biosynthetic Process Response To Endoplasmic Reticulum Stress Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Exocytosis Negative Regulation Of Synaptic Transmission, Glutamatergic Maternal Process Involved In Female Pregnancy Positive Regulation Of Protein Kinase C Signaling Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Arachidonic Acid Secretion Positive Regulation Of Blood Vessel Diameter Regulation Of Store-operated Calcium Channel Activity Positive Regulation Of Ceramide Biosynthetic Process
Pathways		Acyl chain remodelling of PC Acyl chain remodeling of CL Acyl chain remodelling of PE Role of phospholipids in phagocytosis COPI-independent Golgi-to-ER retrograde traffic
Drugs		Quinacrine
Diseases		Neurodegeneration with brain iron accumulation (NBIA); Hallervorden-Spatz syndrome; Neuroferritinopathy; Aceruloplasminemia Parkinson's disease (PD)
GWAS		Body fat percentage ( 26833246) Breast cancer ( 29059683) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Cutaneous nevi ( 21478494 19578365) Mammographic density (dense area) ( 25342443) Melanoma ( 21983787 28212542) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 30429480) Percent mammographic density ( 25342443) Triglyceride levels ( 28334899) Triglycerides ( 24097068 20686565)
Interacting Genes		1 interacting genes: CALM1
Entrez ID		8398
HPRD ID		04675
Ensembl ID		ENSG00000184381
Uniprot IDs		O60733
PDB IDs
Enriched GO Terms of Interacting Partners?
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