FZD8

Description		frizzled class receptor 8
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GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Membrane Wnt-Frizzled-LRP5/6 Complex
	Molecular Function	G Protein-coupled Receptor Activity Signaling Receptor Binding Protein Binding Wnt-protein Binding PDZ Domain Binding Ubiquitin Protein Ligase Binding Wnt-activated Receptor Activity
	Biological Process	Angiogenesis G Protein-coupled Receptor Signaling Pathway Neuron Differentiation T Cell Differentiation In Thymus Non-canonical Wnt Signaling Pathway Positive Regulation Of JUN Kinase Activity Canonical Wnt Signaling Pathway
Pathways		Class B/2 (Secretin family receptors) Asymmetric localization of PCP proteins Regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation
Drugs
Diseases
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Periodontal microbiota ( 22699663) Protein quantitative trait loci ( 18464913)
Interacting Genes		7 interacting genes: CUL2 GOPC LRP5 LRP6 RAE1 RYK WNT1
Entrez ID		8325
HPRD ID		05852
Ensembl ID		ENSG00000177283
Uniprot IDs		Q9H461
PDB IDs		5UN5 5UN6 6NDZ
Enriched GO Terms of Interacting Partners?
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