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KDM6A

Description lysine demethylase 6A
Image
GO Annotations Cellular Component
  • Nuclear Chromatin
  • Nucleus
  • Nucleoplasm
  • Histone Methyltransferase Complex
  • MLL3/4 Complex
Molecular Function
  • RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding
  • Chromatin Binding
  • Chromatin DNA Binding
  • Identical Protein Binding
  • Sequence-specific DNA Binding
  • Metal Ion Binding
  • Dioxygenase Activity
  • Histone Demethylase Activity (H3-K27 Specific)
Biological Process
  • In Utero Embryonic Development
  • Neural Tube Closure
  • Heart Morphogenesis
  • Respiratory System Process
  • Chromatin Remodeling
  • Positive Regulation Of Gene Expression
  • Somite Rostral/caudal Axis Specification
  • Multicellular Organism Growth
  • Mesodermal Cell Differentiation
  • Notochord Morphogenesis
  • Histone H3-K4 Methylation
  • Oxidation-reduction Process
  • Canonical Wnt Signaling Pathway
  • Histone H3-K27 Demethylation
  • Cardiovascular System Development
Pathways
  • HDMs demethylate histones
  • Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS
Interacting Genes 9 interacting genes: H3-4 H3C1 H3C14 MTDH NKX2-5 SMAD9 SRF TBX5 TLE1
Entrez ID 7403
HPRD ID 02131
Ensembl ID ENSG00000147050
Uniprot IDs B4E0L8 B7ZKN1 B7ZKN5 B7ZKN6 E1U0S6 O15550 Q59HG3 Q86TD1
PDB IDs 3AVR 3AVS 6FUK 6FUL
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025

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