TGIF1

Description		TGFB induced factor homeobox 1
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleoplasm
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Co-SMAD Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Response To Drug Cellular Response To Growth Factor Stimulus
Pathways		Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Drugs
Diseases		Holoprosencephaly (HPE)
GWAS		Metabolite levels ( 23823483) Periodontitis (DPAL) ( 24024966) Response to methotrexate in juvenile idiopathic arthritis ( 24709693)
Interacting Genes		21 interacting genes: A2M APP AR CTBP1 CTBP2 EEF1A1 HDAC1 HMGB1 IRF2BP1 JUN LRIF1 MAPK1 MAPK3 MDFI MED31 MOB3A PML SIN3A SMAD2 SMAD3 WWP1
Entrez ID		7050
HPRD ID		04023
Ensembl ID		ENSG00000177426
Uniprot IDs		Q15583
PDB IDs		2LK2 6FQP 6FQQ
Enriched GO Terms of Interacting Partners?
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