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ABCC8

Description ATP binding cassette subfamily C member 8
Image
GO Annotations Cellular Component
  • Plasma Membrane
  • Inward Rectifying Potassium Channel
  • Membrane
  • Potassium Ion-transporting ATPase Complex
Molecular Function
  • Potassium Channel Activity
  • ATP Binding
  • Sulfonylurea Receptor Activity
  • ATP-activated Inward Rectifier Potassium Channel Activity
  • ATPase Activity
  • Cation-transporting ATPase Activity
  • ATPase Activity, Coupled To Transmembrane Movement Of Substances
  • Ion Channel Binding
Biological Process
  • Potassium Ion Transport
  • Regulation Of Insulin Secretion
  • Transmembrane Transport
  • Potassium Ion Transmembrane Transport
  • Inorganic Cation Transmembrane Transport
Pathways
  • ATP sensitive Potassium channels
  • Regulation of insulin secretion
  • Defective ABCC8 can cause hypoglycemias and hyperglycemias
Drugs
  • ATP
  • Glimepiride
  • Chlorpropamide
  • Nateglinide
  • Tolazamide
  • Repaglinide
  • Glyburide
  • Glipizide
  • Gliclazide
  • Tolbutamide
  • Gliquidone
  • Mitiglinide
  • Glycodiazine
Diseases
  • Permanent neonatal diabetes mellitus (PNDM)
  • Transient neonatal diabetes mellitus (TNDM)
GWAS
  • Alcohol dependence symptom count ( 29460428)
  • Body mass index ( 26426971)
  • Gout ( 22179738)
  • Mean arterial pressure ( 27618448)
  • Metabolite levels ( 23823483)
  • Type 2 diabetes ( 29632382)
  • Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes 4 interacting genes: CRYBB1 ENSA KCNJ11 KCNJ8
Entrez ID 6833
HPRD ID 02741
Ensembl ID ENSG00000006071
Uniprot IDs Q09428
PDB IDs 6C3O 6C3P
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025

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