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PORCN

Description porcupine O-acyltransferase
Image No pdb structure
GO Annotations Cellular Component
  • Endoplasmic Reticulum
  • Endoplasmic Reticulum Membrane
  • Integral Component Of Endoplasmic Reticulum Membrane
  • AMPA Glutamate Receptor Complex
  • Glutamatergic Synapse
Molecular Function
  • Wnt-protein Binding
  • Palmitoleoyltransferase Activity
Biological Process
  • Protein Lipidation
  • Glycoprotein Metabolic Process
  • Wnt Signaling Pathway
  • Protein Palmitoleylation
  • Canonical Wnt Signaling Pathway
  • Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Pathways
  • WNT ligand biogenesis and trafficking
  • WNT ligand secretion is abrogated by the PORCN inhibitor LGK974
Drugs
Diseases
  • Focal dermal hypoplasia; Goltz-Gorlin syndrome
GWAS
Interacting Genes 6 interacting genes: WNT1 WNT3A WNT4 WNT5B WNT6 WNT7B
Entrez ID 64840
HPRD ID 06680
Ensembl ID ENSG00000102312
Uniprot IDs Q9H237
PDB IDs
Enriched GO Terms of Interacting Partners?
Tagcloud ?

© Madhavi K. Ganapathiraju 2012-2025

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