MAP2K5

Description		mitogen-activated protein kinase kinase 5
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GO Annotations	Cellular Component	Nucleus Cytoplasm Spindle Cytosol
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Activation Of MAPK Activity Signal Transduction Regulation Of Mitotic Cell Cycle Heart Development Peptidyl-tyrosine Phosphorylation Signal Transduction By Protein Phosphorylation Positive Regulation Of Cell Growth Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of NF-kappaB Transcription Factor Activity Activation Of Protein Kinase Activity Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Response To Cytokine Stimulus ERK5 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Signalling to ERK5
Drugs
Diseases
GWAS		Bipolar disorder or body mass index ( 31754094) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 28552196 22344219 26961502 24861553 28892062 25673413 20935630 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Dental caries (decayed and filled deciduous teeth) ( 31533690) Menarche (age at onset) ( 25231870) Motion sickness ( 25628336) Obesity ( 23563607) Restless legs syndrome ( 17637780 29029846 21779176) Smoking status (ever vs never smokers) ( 30643258) Type 2 diabetes ( 30297969) Verbal declarative memory ( 25648963) Waist circumference ( 25673412) Weight ( 28552196)
Interacting Genes		49 interacting genes: AKT1 ARAF ARNT ASRGL1 BAD BECN1 CCND2 CD44 CDC42BPB CDK4 CDK6 CDKN2A CDKN2B CDKN2C EPHA2 ERBB2 ESRRA FGFR4 FZR1 GLIS2 GRM1 HGF HIF1A LATS2 LNX2 MAP2K3 MAP2K6 MAP3K2 MAP3K3 MAPK7 MDM4 MET MYC NF2 PARD6A PDGFRA PRKCI PRKCZ RAF1 RPL28 SQSTM1 STAMBP STK11 TEAD2 TERT TP53 TSC1 XRCC6 YWHAZ
Entrez ID		5607
HPRD ID		03951
Ensembl ID		ENSG00000137764
Uniprot IDs		A0A024R5X5 A0A024R5Y2 Q13163
PDB IDs		2NPT 2O2V 4IC7
Enriched GO Terms of Interacting Partners?
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