CDK12

Description		cyclin dependent kinase 12
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GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nuclear Chromatin Cyclin K-CDK12 Complex Nucleus Nucleoplasm Nuclear Speck Nuclear Cyclin-dependent Protein Kinase Holoenzyme Complex
	Molecular Function	Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Protein Kinase Binding Cyclin Binding
	Biological Process	MRNA Processing Protein Phosphorylation RNA Splicing Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of MAP Kinase Activity Regulation Of RNA Splicing Protein Autophosphorylation Regulation Of Cell Cycle Phosphorylation Of RNA Polymerase II C-terminal Domain Negative Regulation Of Stem Cell Differentiation
Pathways		TP53 Regulates Transcription of DNA Repair Genes
Drugs
Diseases
GWAS		Asthma ( 31619474) Blood urea nitrogen levels ( 31152163) Estimated glomerular filtration rate ( 31152163 30604766) Glomerular filtration rate ( 27588450) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Lung function (FVC) ( 30061609) Menopause (age at onset) ( 26414677) Triglyceride levels ( 30108155)
Interacting Genes		10 interacting genes: CLK1 EWSR1 MBP PCNT PIN1 POLR2A PRPF40A SRPK2 SRSF1 SRSF2
Entrez ID		51755
HPRD ID		10849
Ensembl ID		ENSG00000167258
Uniprot IDs		Q9NYV4
PDB IDs		4CXA 4NST 4UN0 5ACB 6B3E 6CKX
Enriched GO Terms of Interacting Partners?
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