TLR8

Description		toll like receptor 8
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GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Plasma Membrane External Side Of Plasma Membrane Endosome Membrane Integral Component Of Membrane Endolysosome Membrane
	Molecular Function	DNA Binding RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Transmembrane Signaling Receptor Activity Drug Binding Signaling Receptor Activity Pattern Recognition Receptor Activity
	Biological Process	Microglial Cell Activation Regulation Of Protein Phosphorylation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Immune Response I-kappaB Kinase/NF-kappaB Signaling Response To Virus Immunoglobulin Mediated Immune Response Positive Regulation Of Interleukin-6 Production Toll-like Receptor 8 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Interferon-gamma Biosynthetic Process Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Interferon-alpha Biosynthetic Process Positive Regulation Of Interferon-beta Biosynthetic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Interleukin-1 Beta Secretion Defense Response To Virus Cellular Response To Mechanical Stimulus Positive Regulation Of Interleukin-6 Secretion Negative Regulation Of Interleukin-12 Secretion
Pathways		Trafficking and processing of endosomal TLR Toll Like Receptor 7/8 (TLR7/8) Cascade TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome
Drugs		Imiquimod
Diseases
GWAS		Celiac disease ( 20190752)
Interacting Genes		2 interacting genes: BTK MYD88
Entrez ID		51311
HPRD ID		02296
Ensembl ID		ENSG00000101916
Uniprot IDs		Q9NR97
PDB IDs		3W3G 3W3J 3W3K 3W3L 3W3M 3W3N 3WN4 4QBZ 4QC0 4R07 4R08 4R09 4R0A 4R6A 5AWA 5AWB 5AWC 5AWD 5AZ5 5HDH 5WYX 5WYZ 5Z14 5Z15
Enriched GO Terms of Interacting Partners?
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