ATIC

Description		5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	IMP Cyclohydrolase Activity Phosphoribosylaminoimidazolecarboxamide Formyltransferase Activity Protein Homodimerization Activity Cadherin Binding
	Biological Process	Brainstem Development Nucleobase-containing Compound Metabolic Process 'de Novo' IMP Biosynthetic Process Nucleoside Metabolic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Response To Inorganic Substance Cerebellum Development Cerebral Cortex Development Animal Organ Regeneration Dihydrofolate Metabolic Process Tetrahydrofolate Biosynthetic Process Cellular Response To Interleukin-7
Pathways		Purine ribonucleoside monophosphate biosynthesis
Drugs		Tetrahydrofolic acid Pemetrexed AICA ribonucleotide Guanosine-5'-Monophosphate 5--Monophosphate-9-Beta-D-Ribofuranosyl Xanthine 2-[5-Hydroxy-3-Methyl-1-(2-Methyl-4-Sulfo-Phenyl)-1h-Pyrazol-4-Ylazo]-4-Sulfo-Benzoic Acid Beta-Dadf, Msa, Multisubstrate Adduct Inhibitor
Diseases		AICA-ribosiduria; ATIC deficiency
GWAS		Airway imaging phenotypes ( 26030696) Metabolite levels ( 23823483)
Interacting Genes		4 interacting genes: EGFR MTNR1A PRNP SERPINB5
Entrez ID		471
HPRD ID		03434
Ensembl ID		ENSG00000138363
Uniprot IDs		P31939 V9HWH7
PDB IDs		1P4R 1PKX 1PL0 5UY8 5UZ0
Enriched GO Terms of Interacting Partners?
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