AREG

Description		amphiregulin
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Nucleus Endoplasmic Reticulum Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Clathrin-coated Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Cytokine Activity Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	MAPK Cascade ER To Golgi Vesicle-mediated Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Proliferation Positive Regulation Of Keratinocyte Proliferation Glial Cell Proliferation Neuron Projection Development Response To Estradiol Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Response To Hydrogen Peroxide Response To Peptide Hormone Negative Regulation Of Osteoblast Differentiation COPII Vesicle Coating Positive Regulation Of Peptidyl-tyrosine Phosphorylation Response To Glucocorticoid Response To CAMP Positive Regulation Of Protein Kinase B Signaling Dichotomous Subdivision Of Terminal Units Involved In Mammary Gland Duct Morphogenesis Mammary Gland Branching Involved In Thelarche Mammary Gland Alveolus Development Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Membrane Organization
Pathways		PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation COPII-mediated vesicle transport EGFR interacts with phospholipase C-gamma Constitutive Signaling by Aberrant PI3K in Cancer Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade Cargo concentration in the ER PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Drugs
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Breast size ( 22747683 27182965) Mammographic density (dense area) ( 25342443) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472)
Interacting Genes		8 interacting genes: APP CCND3 EGFR KRTAP10-3 MMP9 UBQLN4 WDR92 WT1
Entrez ID		374
HPRD ID		00093
Ensembl ID		ENSG00000109321
Uniprot IDs		P15514
PDB IDs		2RNL
Enriched GO Terms of Interacting Partners?
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