HLA-DRB5

Description		major histocompatibility complex, class II, DR beta 5
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GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Plasma Membrane ER To Golgi Transport Vesicle Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Extracellular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Peptide Antigen Binding
	Biological Process	Adaptive Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Receptor Signaling Pathway Interferon-gamma-mediated Signaling Pathway
Pathways		Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling
Drugs
Diseases
GWAS		Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 30617256 24162737) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Antinuclear antibody levels ( 25186300) Asthma ( 30929738 27182965 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Automobile speeding propensity ( 30643258) Blood protein levels ( 29875488) Body mass index ( 28892062) Childhood ear infection ( 27182965) Chronic lymphocytic leukemia ( 21131588 26956414) Crohn's disease ( 23850713) Epstein Barr virus nuclear antigen 1 IgG levels ( 26819262) Frontotemporal dementia ( 24943344) Hand grip strength ( 29691431) Heart rate response to exercise ( 29769521) Hypothyroidism ( 22493691) Immune response to measles vaccine (measles-induced IFN gamma) ( 28289848) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Joint damage in rheumatoid arthritis ( 31596875) Lymphoma ( 23349640) Parkinson's disease ( 21292315 27182965) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Prostate cancer ( 23535732) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Sarcoidosis (non-Lofgren's syndrome) ( 26651848) SjÃ¶gren's syndrome ( 24097066) Tuberculosis ( 29036319) Type 2 diabetes ( 28869590) Ulcerative colitis ( 28067908 21297633 19122664) Vogt-Koyanagi-Harada syndrome ( 25108386) Waist-to-hip ratio adjusted for body mass index ( 26785701)
Interacting Genes		2 interacting genes: CTAG1B HLA-DRA
Entrez ID		3127
HPRD ID		09209
Ensembl ID		ENSG00000198502
Uniprot IDs		A0A2Z4LKS3 Q30154
PDB IDs		1FV1 1H15 1HQR 1ZGL
Enriched GO Terms of Interacting Partners?
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