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HCRTR1

Description hypocretin receptor 1
Image
GO Annotations Cellular Component
  • Cell
  • Plasma Membrane
  • Integral Component Of Plasma Membrane
  • Synapse
Molecular Function
  • G Protein-coupled Receptor Activity
  • Protein Binding
  • Orexin Receptor Activity
  • Peptide Hormone Binding
  • Peptide Binding
Biological Process
  • G Protein-coupled Receptor Signaling Pathway
  • Neuropeptide Signaling Pathway
  • Chemical Synaptic Transmission
  • Feeding Behavior
  • Cellular Response To Hormone Stimulus
  • Regulation Of Cytosolic Calcium Ion Concentration
  • Positive Regulation Of ERK1 And ERK2 Cascade
Pathways
  • Orexin and neuropeptides FF and QRFP bind to their respective receptors
  • G alpha (q) signalling events
Drugs
  • Suvorexant
Diseases
GWAS
  • Body mass index ( 26426971)
  • Cognitive ability ( 29186694)
  • Cognitive ability (MTAG) ( 29186694)
  • General cognitive ability ( 29844566)
Interacting Genes 6 interacting genes: ARRB1 ARRB2 ATP1B1 CNR1 HCRT PABPC4
Entrez ID 3061
HPRD ID 03863
Ensembl ID ENSG00000121764
Uniprot IDs A6NMV7 O43613
PDB IDs 4ZJ8 4ZJC
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025

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