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FGR
Description
FGR proto-oncogene, Src family tyrosine kinase
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Mitochondrial Inner Membrane
Mitochondrial Intermembrane Space
Cytosol
Cytoskeleton
Plasma Membrane
Actin Cytoskeleton
Aggresome
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Ruffle Membrane
Secretory Granule Lumen
Extracellular Exosome
Molecular Function
Phosphotyrosine Residue Binding
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Protein Kinase Binding
Immunoglobulin Receptor Binding
Fc-gamma Receptor I Complex Binding
Biological Process
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Protein Phosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Integrin-mediated Signaling Pathway
Regulation Of Cell Shape
Response To Virus
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Cell Differentiation
Bone Mineralization
Positive Regulation Of Cell Migration
Negative Regulation Of Natural Killer Cell Activation
Peptidyl-tyrosine Autophosphorylation
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Regulation Of Cell Proliferation
Positive Regulation Of Mast Cell Degranulation
Neutrophil Degranulation
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Innate Immune Response
Regulation Of Innate Immune Response
Regulation Of Protein Kinase Activity
Protein Autophosphorylation
Skeletal System Morphogenesis
Positive Regulation Of Cytokine Secretion
Regulation Of Phagocytosis
Defense Response To Gram-positive Bacterium
Pathways
FCGR activation
Platelet sensitization by LDL
Neutrophil degranulation
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
Drugs
Dasatinib
Diseases
GWAS
Body mass index (
28892062
)
Systolic blood pressure (
30224653
)
Interacting Genes
25 interacting genes:
ARRB1
CBL
CCR3
CSK
DAB2
DOK1
EGFR
ERBB2
FASLG
HCLS1
IKBKG
INPP5D
KHDRBS1
NR1I2
PTK2
SKAP2
SLAMF1
SMURF1
SNCA
SRC
STAT3
SYK
VDR
WAS
YWHAQ
Entrez ID
2268
HPRD ID
01288
Ensembl ID
ENSG00000000938
Uniprot IDs
P09769
P78453
PDB IDs
Enriched GO Terms of Interacting Partners
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