FDFT1

Description		farnesyl-diphosphate farnesyltransferase 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Farnesyl-diphosphate Farnesyltransferase Activity Protein Binding Metal Ion Binding Squalene Synthase Activity
	Biological Process	Steroid Biosynthetic Process Cholesterol Biosynthetic Process Ergosterol Biosynthetic Process Regulation Of Lipid Metabolic Process Farnesyl Diphosphate Metabolic Process Regulation Of Cholesterol Biosynthetic Process
Pathways		Cholesterol biosynthesis PPARA activates gene expression Activation of gene expression by SREBF (SREBP)
Drugs		TAK-475
Diseases
GWAS		Blood protein levels ( 28240269) C-reactive protein levels ( 30388399) Ejection fraction in Tripanosoma cruzi seropositivity ( 24324551) General factor of neuroticism ( 30867560) Heschl's gyrus morphology ( 25130324) Metabolite levels ( 23823483) Non-alcoholic fatty liver disease histology (lobular) ( 20708005) Non-alcoholic fatty liver disease histology (other) ( 20708005) Polycystic ovary syndrome ( 26284813)
Interacting Genes		8 interacting genes: ANXA5 ARL6IP1 CREB3 LMNA RFLNA RUVBL2 SHPRH TMEM43
Entrez ID		2222
HPRD ID		01694
Ensembl ID		ENSG00000079459
Uniprot IDs		A0A1W2PQ47 B4DND3 B4DWP0 B7Z9R8 P37268 Q6IAX1
PDB IDs		1EZF 3ASX 3LEE 3Q2Z 3Q30 3V66 3VJ8 3VJ9 3VJA 3VJB 3VJC 3WC9 3WCD 3WCF 3WCH 3WCI 3WCJ 3WCL 3WCM 3WEF 3WEG 3WEH 3WEI 3WEJ 3WEK 3WSA
Enriched GO Terms of Interacting Partners?
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