COL1A2

Description		collagen type I alpha 2 chain
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GO Annotations	Cellular Component	Extracellular Region Collagen Type I Trimer Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Protease Binding Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Protein Binding, Bridging Identical Protein Binding SMAD Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Skeletal System Development Blood Vessel Development Transforming Growth Factor Beta Receptor Signaling Pathway Rho Protein Signal Transduction Blood Coagulation Regulation Of Blood Pressure Cytokine-mediated Signaling Pathway Platelet Activation Extracellular Matrix Organization Collagen Fibril Organization Bone Mineralization Collagen Metabolic Process Odontogenesis Skin Morphogenesis Regulation Of Immune Response Leukocyte Migration Protein Heterotrimerization Cellular Response To Amino Acid Stimulus Extracellular Matrix Assembly
Pathways		GPVI-mediated activation cascade Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans Scavenging by Class A Receptors GP1b-IX-V activation signalling Interleukin-4 and Interleukin-13 signaling Platelet Adhesion to exposed collagen Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) MET activates PTK2 signaling Collagen chain trimerization
Drugs		Collagenase clostridium histolyticum
Diseases		Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS) Osteogenesis imperfecta
GWAS		Aging ( 22773346) Heel bone mineral density ( 30598549) Immune reponse to smallpox (secreted IL-12p40) ( 22610502) Intelligence ( 22449649) Low bone mineral density (hip) ( 26235824) Low bone mineral density (spine) ( 26235824) Mean forced vital capacity from 2 exams ( 17903307) Post bronchodilator FEV1 ( 26634245) PR interval in Tripanosoma cruzi seropositivity ( 24324551)
Interacting Genes		27 interacting genes: APP BGN CD36 CD44 CD93 COL5A3 DCN FN1 ITGA2 ITGA2B ITGB3 KCNIP4 LIG4 LUM MMP9 MYOC P4HB PDGFA PDGFB SERPINB5 SGTA SGTB SHBG SPARC TGFBI UBQLN1 VWF
Entrez ID		1278
HPRD ID		00363
Ensembl ID		ENSG00000164692
Uniprot IDs		A0A0S2Z3H5 P08123
PDB IDs		5CTD 5CTI 5CVA
Enriched GO Terms of Interacting Partners?
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