Search Results for: TUBB2A

Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
ACD ACD shelterin complex subunit and telomerase recruitment factor
  • Recognition and association of DNA glycosylase with site containing an affected pyrimidine
  • Cleavage of the damaged pyrimidine
  • Recognition and association of DNA glycosylase with site containing an affected purine
  • Recognition and association of DNA glycosylase with site containing an affected purine
  • Cleavage of the damaged purine
  • Cleavage of the damaged purine
  • Meiotic synapsis
  • Packaging Of Telomere Ends
  • Telomere Extension By Telomerase
  • Polymerase switching on the C-strand of the telomere
  • Processive synthesis on the C-strand of the telomere
  • Telomere C-strand (Lagging Strand) Synthesis
  • Telomere C-strand synthesis initiation
  • Removal of the Flap Intermediate from the C-strand
  • DNA Damage/Telomere Stress Induced Senescence
  • Inhibition of DNA recombination at telomere
ARL15 ADP ribosylation factor like GTPase 15
ARNT aryl hydrocarbon receptor nuclear translocator
  • Regulation of gene expression by Hypoxia-inducible Factor
  • PPARA activates gene expression
  • Phase I - Functionalization of compounds
  • Endogenous sterols
  • Xenobiotics
  • Aryl hydrocarbon receptor signalling
CHGB chromogranin B
  • Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
  • Post-translational protein phosphorylation
DISC1 DISC1 scaffold protein
DUX4 double homeobox 4
HDAC6 histone deacetylase 6
  • NOTCH1 Intracellular Domain Regulates Transcription
  • Constitutive Signaling by NOTCH1 PEST Domain Mutants
  • Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
  • HSF1 activation
  • Notch-HLH transcription pathway
  • Cilium Assembly
  • Transcriptional regulation by RUNX2
  • RUNX2 regulates osteoblast differentiation
  • Chaperone Mediated Autophagy
  • Late endosomal microautophagy
  • Aggrephagy
  • Aggrephagy
  • Vorinostat
  • Belinostat
  • Pracinostat
  • Romidepsin
  • Panobinostat
  • Bufexamac
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
  • EGFR downregulation
  • Lysosome Vesicle Biogenesis
  • Ub-specific processing proteases
  • Negative regulation of MET activity
  • Cargo recognition for clathrin-mediated endocytosis
  • Clathrin-mediated endocytosis
  • InlB-mediated entry of Listeria monocytogenes into host cell
  • Endosomal Sorting Complex Required For Transport (ESCRT)
  • Inhibition of membrane repair
  • Prevention of phagosomal-lysosomal fusion
  • RHOBTB3 ATPase cycle
  • Citric acid
HMMR hyaluronan mediated motility receptor
  • Hyaluronan uptake and degradation
  • AURKA Activation by TPX2
  • Hyaluronic acid
LAMA4 laminin subunit alpha 4
  • Laminin interactions
  • Laminin interactions
  • Non-integrin membrane-ECM interactions
  • ECM proteoglycans
  • MET activates PTK2 signaling
LINC01554 long intergenic non-protein coding RNA 1554
PAFAH1B3 platelet activating factor acetylhydrolase 1b catalytic subunit 3
  • COPI-independent Golgi-to-ER retrograde traffic
  • (1R)-1,2,2-trimethylpropyl (R)-methylphosphinate
POT1 protection of telomeres 1
  • Recognition and association of DNA glycosylase with site containing an affected pyrimidine
  • Cleavage of the damaged pyrimidine
  • Recognition and association of DNA glycosylase with site containing an affected purine
  • Recognition and association of DNA glycosylase with site containing an affected purine
  • Cleavage of the damaged purine
  • Cleavage of the damaged purine
  • Meiotic synapsis
  • Packaging Of Telomere Ends
  • Telomere Extension By Telomerase
  • Polymerase switching on the C-strand of the telomere
  • Processive synthesis on the C-strand of the telomere
  • Telomere C-strand (Lagging Strand) Synthesis
  • Telomere C-strand synthesis initiation
  • Removal of the Flap Intermediate from the C-strand
  • DNA Damage/Telomere Stress Induced Senescence
  • Inhibition of DNA recombination at telomere
PSMD11 proteasome 26S subunit, non-ATPase 11
  • Activation of NF-kappaB in B cells
  • Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
  • ER-Phagosome pathway
  • Cross-presentation of soluble exogenous antigens (endosomes)
  • Autodegradation of Cdh1 by Cdh1:APC/C
  • SCF-beta-TrCP mediated degradation of Emi1
  • APC/C:Cdc20 mediated degradation of Securin
  • APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
  • Cdc20:Phospho-APC/C mediated degradation of Cyclin A
  • Vpu mediated degradation of CD4
  • Vif-mediated degradation of APOBEC3G
  • SCF(Skp2)-mediated degradation of p27/p21
  • Degradation of beta-catenin by the destruction complex
  • Downstream TCR signaling
  • Regulation of activated PAK-2p34 by proteasome mediated degradation
  • Separation of Sister Chromatids
  • FCERI mediated NF-kB activation
  • Autodegradation of the E3 ubiquitin ligase COP1
  • Regulation of ornithine decarboxylase (ODC)
  • ABC-family proteins mediated transport
  • AUF1 (hnRNP D0) binds and destabilizes mRNA
  • Asymmetric localization of PCP proteins
  • Degradation of AXIN
  • Degradation of DVL
  • Hedgehog ligand biogenesis
  • Hh mutants are degraded by ERAD
  • Dectin-1 mediated noncanonical NF-kB signaling
  • CLEC7A (Dectin-1) signaling
  • Degradation of GLI1 by the proteasome
  • Degradation of GLI2 by the proteasome
  • GLI3 is processed to GLI3R by the proteasome
  • Hedgehog 'on' state
  • Regulation of RAS by GAPs
  • TNFR2 non-canonical NF-kB pathway
  • NIK-->noncanonical NF-kB signaling
  • Defective CFTR causes cystic fibrosis
  • MAPK6/MAPK4 signaling
  • UCH proteinases
  • Ub-specific processing proteases
  • Neutrophil degranulation
  • CDT1 association with the CDC6:ORC:origin complex
  • Orc1 removal from chromatin
  • CDK-mediated phosphorylation and removal of Cdc6
  • G2/M Checkpoints
  • Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
  • Ubiquitin-dependent degradation of Cyclin D
  • The role of GTSE1 in G2/M progression after G2 checkpoint
  • FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
  • RUNX1 regulates transcription of genes involved in differentiation of HSCs
  • Regulation of RUNX2 expression and activity
  • Regulation of RUNX2 expression and activity
  • Regulation of RUNX3 expression and activity
  • Regulation of PTEN stability and activity
  • Neddylation
  • Regulation of expression of SLITs and ROBOs
  • Interleukin-1 signaling
  • Negative regulation of NOTCH4 signaling
  • Antigen processing: Ubiquitination & Proteasome degradation
PTPRS protein tyrosine phosphatase receptor type S
  • ECM proteoglycans
  • Receptor-type tyrosine-protein phosphatases
  • Synaptic adhesion-like molecules
  • Signaling by NTRK3 (TRKC)
  • Alendronic acid
  • Etidronic acid
RABAC1 Rab acceptor 1
RIC8A RIC8 guanine nucleotide exchange factor A
RPA2 replication protein A2
  • Translesion synthesis by REV1
  • Recognition of DNA damage by PCNA-containing replication complex
  • Translesion Synthesis by POLH
  • Removal of the Flap Intermediate from the C-strand
  • Activation of ATR in response to replication stress
  • Regulation of HSF1-mediated heat shock response
  • HSF1 activation
  • Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
  • Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
  • Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
  • PCNA-Dependent Long Patch Base Excision Repair
  • Translesion synthesis by POLK
  • Translesion synthesis by POLI
  • Termination of translesion DNA synthesis
  • HDR through Single Strand Annealing (SSA)
  • HDR through Homologous Recombination (HRR)
  • Processing of DNA double-strand break ends
  • Presynaptic phase of homologous DNA pairing and strand exchange
  • Formation of Incision Complex in GG-NER
  • Gap-filling DNA repair synthesis and ligation in GG-NER
  • Dual Incision in GG-NER
  • Dual incision in TC-NER
  • Gap-filling DNA repair synthesis and ligation in TC-NER
  • Fanconi Anemia Pathway
  • Regulation of TP53 Activity through Phosphorylation
  • Activation of the pre-replicative complex
  • Removal of the Flap Intermediate
  • G2/M DNA damage checkpoint
  • Meiotic recombination
RPLP1 ribosomal protein lateral stalk subunit P1
  • L13a-mediated translational silencing of Ceruloplasmin expression
  • Peptide chain elongation
  • SRP-dependent cotranslational protein targeting to membrane
  • SRP-dependent cotranslational protein targeting to membrane
  • Viral mRNA Translation
  • Selenocysteine synthesis
  • Major pathway of rRNA processing in the nucleolus and cytosol
  • Formation of a pool of free 40S subunits
  • GTP hydrolysis and joining of the 60S ribosomal subunit
  • Eukaryotic Translation Termination
  • Regulation of expression of SLITs and ROBOs
  • Response of EIF2AK4 (GCN2) to amino acid deficiency
  • Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
  • Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SAT1 spermidine/spermine N1-acetyltransferase 1
  • Interconversion of polyamines
  • N-ethyl-N-[3-(propylamino)propyl]propane-1,3-diamine
  • Keratosis follicularis spinulosa decalvans

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