|
|
TUBB |
tubulin beta class I |
- Regulation of PLK1 Activity at G2/M Transition
- Loss of Nlp from mitotic centrosomes
- Recruitment of mitotic centrosome proteins and complexes
- Loss of proteins required for interphase microtubule organization from the centrosome
- Recruitment of NuMA to mitotic centrosomes
- Anchoring of the basal body to the plasma membrane
- Neutrophil degranulation
- AURKA Activation by TPX2
- Potential therapeutics for SARS
|
- Vinorelbine
- Vincristine
- Vinblastine
- Podofilox
- Colchicine
- Epothilone D
- Patupilone
- CYT997
- CA4P
- ZEN-012
- Tirbanibulin
- Copper
- Artenimol
- Vinflunine
- Depatuxizumab mafodotin
- Milataxel
- Colchiceine
|
|
|
|
UBE2D3 |
ubiquitin conjugating enzyme E2 D3 |
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- TICAM1, RIP1-mediated IKK complex recruitment
- Signaling by BMP
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- E3 ubiquitin ligases ubiquitinate target proteins
- Neddylation
- Peroxisomal protein import
- Negative regulators of DDX58/IFIH1 signaling
- IKK complex recruitment mediated by RIP1
- Antigen processing: Ubiquitination & Proteasome degradation
|
|
|
|
|
VAV1 |
vav guanine nucleotide exchange factor 1 |
- GPVI-mediated activation cascade
- GPVI-mediated activation cascade
- PIP3 activates AKT signaling
- Signaling by SCF-KIT
- NRAGE signals death through JNK
- Rho GTPase cycle
- Regulation of actin dynamics for phagocytic cup formation
- Constitutive Signaling by Aberrant PI3K in Cancer
- FCERI mediated MAPK activation
- FCERI mediated Ca+2 mobilization
- FCERI mediated Ca+2 mobilization
- CD28 dependent Vav1 pathway
- G alpha (12/13) signalling events
- VEGFA-VEGFR2 Pathway
- VEGFA-VEGFR2 Pathway
- Interleukin-3, Interleukin-5 and GM-CSF signaling
- VEGFR2 mediated vascular permeability
- PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
- Erythropoietin activates RAS
- Erythropoietin activates RAS
- Regulation of signaling by CBL
- FCGR3A-mediated phagocytosis
- FCGR3A-mediated phagocytosis
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
|
|
|
|
|
VCL |
vinculin |
- Platelet degranulation
- Smooth Muscle Contraction
- MAP2K and MAPK activation
- Neutrophil degranulation
- Signaling by moderate kinase activity BRAF mutants
- Signaling by high-kinase activity BRAF mutants
- Signaling by BRAF and RAF fusions
- Paradoxical activation of RAF signaling by kinase inactive BRAF
- Signaling downstream of RAS mutants
- Signaling by RAF1 mutants
|
|
|
|
|
YWHAQ |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta |
- Activation of BAD and translocation to mitochondria
- Translocation of SLC2A4 (GLUT4) to the plasma membrane
- RHO GTPases activate PKNs
- TP53 Regulates Metabolic Genes
- Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
- Regulation of localization of FOXO transcription factors
|
|
|
|
|
ZAP70 |
zeta chain of T cell receptor associated protein kinase 70 |
- Translocation of ZAP-70 to Immunological synapse
- Generation of second messenger molecules
|
- Staurosporine
- Fostamatinib
|
- Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
|