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ESR2 |
estrogen receptor 2 |
- PIP3 activates AKT signaling
- Constitutive Signaling by Aberrant PI3K in Cancer
- Nuclear Receptor transcription pathway
- PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
- ESR-mediated signaling
- Extra-nuclear estrogen signaling
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- Diethylstilbestrol
- Conjugated estrogens
- Progesterone
- Raloxifene
- Estrone
- Tamoxifen
- Estradiol
- Trilostane
- Estramustine
- Oxybenzone
- Genistein
- Prasterone
- Benzophenone
- Phthalic Acid
- Pyrazole
- Para-Mercury-Benzenesulfonic Acid
- Naringenin
- ICI-164384
- 5-Alpha-Androstane-3-Beta,17beta-Diol
- 4-(2-{[4-{[3-(4-Chlorophenyl)Propyl]Sulfanyl}-6-(1-Piperazinyl)-1,3,5-Triazin-2-Yl]Amino}Ethyl)Phenol
- Quercetin
- Afimoxifene
- Estriol
- Estrone sulfate
- MF101
- CHF 4227
- TAS-108
- Lasofoxifene
- Arzoxifene
- Bazedoxifene
- Prinaberel
- ERB-196
- [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE
- 4-(6-HYDROXY-BENZO[D]ISOXAZOL-3-YL)BENZENE-1,3-DIOL
- 2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OL
- 2-(4-HYDROXY-PHENYL)BENZOFURAN-5-OL
- (3aS,4R,9bR)-2,2-difluoro-4-(4-hydroxyphenyl)-6-(methoxymethyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-ol
- 1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL
- 4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME
- 5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILE
- 3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONE
- 3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OL
- (3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL
- 17alpha-Estriol
- (9aS)-4-bromo-9a-butyl-7-hydroxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one
- Erteberel
- (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL
- Eugenol
- Octocrylene
- Enzacamene
- Equol
- 2-Methoxy-6-{(E)-[(4-methylphenyl)imino]methyl}phenol
- Estradiol acetate
- Estradiol benzoate
- Estradiol cypionate
- Estradiol dienanthate
- Estradiol valerate
- Estriol tripropionate
- Fluoroestradiol F-18
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ESRRA |
estrogen related receptor alpha |
- PPARA activates gene expression
- Transcriptional activation of mitochondrial biogenesis
- Transcriptional activation of mitochondrial biogenesis
- Nuclear Receptor transcription pathway
- Regulation of RUNX2 expression and activity
- Regulation of RUNX2 expression and activity
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- Troglitazone
- Diethylstilbestrol
- Genistein
- Afimoxifene
- beta-Naphthoflavone
- 1-CYCLOHEXYL-N-{[1-(4-METHYLPHENYL)-1H-INDOL-3-YL]METHYL}METHANAMINE
- Flavone
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ESRRB |
estrogen related receptor beta |
- Nuclear Receptor transcription pathway
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- Diethylstilbestrol
- Genistein
- Flavone
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ESRRG |
estrogen related receptor gamma |
- Nuclear Receptor transcription pathway
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- Troglitazone
- Diethylstilbestrol
- Tamoxifen
- Cholic Acid
- Afimoxifene
- 4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE
- p-Cumylphenol
- Bisphenol A
- Bisphenol Z
- Estradiol acetate
- Estradiol benzoate
- Estradiol cypionate
- Estradiol dienanthate
- Estradiol valerate
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ETS1 |
ETS proto-oncogene 1, transcription factor |
- Oncogene Induced Senescence
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GABPA |
GA binding protein transcription factor subunit alpha |
- Transcriptional activation of mitochondrial biogenesis
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GATA1 |
GATA binding protein 1 |
- RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
- RUNX1 regulates transcription of genes involved in differentiation of HSCs
- Factors involved in megakaryocyte development and platelet production
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- Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
- Congenital dyserythropoietic anemias (CDAs)
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GATA3 |
GATA binding protein 3 |
- Ub-specific processing proteases
- Interleukin-4 and Interleukin-13 signaling
- RUNX1 regulates transcription of genes involved in differentiation of HSCs
- Estrogen-dependent gene expression
- Factors involved in megakaryocyte development and platelet production
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GATA4 |
GATA binding protein 4 |
- YAP1- and WWTR1 (TAZ)-stimulated gene expression
- Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
- Physiological factors
- Transcriptional regulation of testis differentiation
- Factors involved in megakaryocyte development and platelet production
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HBZ |
hemoglobin subunit zeta |
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HCFC1 |
host cell factor C1 |
- Transcriptional activation of mitochondrial biogenesis
- HATs acetylate histones
- UCH proteinases
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HDAC1 |
histone deacetylase 1 |
- Transcription of E2F targets under negative control by DREAM complex
- Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
- G0 and Early G1
- p75NTR negatively regulates cell cycle via SC1
- Formation of the beta-catenin:TCF transactivating complex
- NOTCH1 Intracellular Domain Regulates Transcription
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- HDACs deacetylate histones
- Notch-HLH transcription pathway
- Deactivation of the beta-catenin transactivating complex
- ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
- NoRC negatively regulates rRNA expression
- SUMOylation of chromatin organization proteins
- Repression of WNT target genes
- Repression of WNT target genes
- Regulation of TP53 Activity through Acetylation
- G1/S-Specific Transcription
- RNA Polymerase I Transcription Initiation
- RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
- Regulation of PTEN gene transcription
- Regulation of PTEN gene transcription
- Estrogen-dependent gene expression
- Loss of MECP2 binding ability to 5mC-DNA
- Regulation of MECP2 expression and activity
- MECP2 regulates neuronal receptors and channels
- MECP2 regulates transcription of neuronal ligands
- FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
- Potential therapeutics for SARS
- Factors involved in megakaryocyte development and platelet production
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- Arsenic trioxide
- Zinc
- Vorinostat
- Belinostat
- Pracinostat
- Romidepsin
- Panobinostat
- Fingolimod
- Mocetinostat
- Abexinostat
- Zinc acetate
- Zinc chloride
- Zinc sulfate, unspecified form
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HDAC2 |
histone deacetylase 2 |
- p75NTR negatively regulates cell cycle via SC1
- NOTCH1 Intracellular Domain Regulates Transcription
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- HDACs deacetylate histones
- Notch-HLH transcription pathway
- ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
- NoRC negatively regulates rRNA expression
- SUMOylation of chromatin organization proteins
- Regulation of TP53 Activity through Acetylation
- RNA Polymerase I Transcription Initiation
- Regulation of PTEN gene transcription
- Regulation of PTEN gene transcription
- Regulation of MECP2 expression and activity
- MECP2 regulates neuronal receptors and channels
- FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
- EGR2 and SOX10-mediated initiation of Schwann cell myelination
- EGR2 and SOX10-mediated initiation of Schwann cell myelination
- Potential therapeutics for SARS
- Factors involved in megakaryocyte development and platelet production
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- Pravastatin
- Lovastatin
- Theophylline
- Valproic acid
- Simvastatin
- Atorvastatin
- Fluvastatin
- Aminophylline
- Oxtriphylline
- Vorinostat
- Belinostat
- Pracinostat
- Romidepsin
- Panobinostat
- Tixocortol
- Mocetinostat
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HIF1A |
hypoxia inducible factor 1 subunit alpha |
- Regulation of gene expression by Hypoxia-inducible Factor
- Cellular response to hypoxia
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- NOTCH1 Intracellular Domain Regulates Transcription
- Circadian Clock
- Ub-specific processing proteases
- Interleukin-4 and Interleukin-13 signaling
- PTK6 Expression
- PTK6 promotes HIF1A stabilization
- Neddylation
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- Carvedilol
- Hydralazine
- 2-Methoxyestradiol
- ENMD-1198
- PX-478
- FG-2216
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HINT1 |
histidine triad nucleotide binding protein 1 |
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- Adenosine phosphate
- Guanosine-5'-Monophosphate
- 5'-O-(N-Ethyl-Sulfamoyl)Adenosine
- Adenosine-5'-ditungstate
- 8-Bromo-Adenosine-5'-Monophosphate
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HLTF |
helicase like transcription factor |
- E3 ubiquitin ligases ubiquitinate target proteins
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HMGA1 |
high mobility group AT-hook 1 |
- Integration of provirus
- 2-LTR circle formation
- Integration of viral DNA into host genomic DNA
- Autointegration results in viral DNA circles
- APOBEC3G mediated resistance to HIV-1 infection
- Vpr-mediated nuclear import of PICs
- Formation of Senescence-Associated Heterochromatin Foci (SAHF)
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HNF4A |
hepatocyte nuclear factor 4 alpha |
- Nuclear Receptor transcription pathway
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- Lauric acid
- AVI-4557
- Myristic acid
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- Maturity onset diabetes of the young (MODY)
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HOXC11 |
homeobox C11 |
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HSPA8 |
heat shock protein family A (Hsp70) member 8 |
- Regulation of HSF1-mediated heat shock response
- HSP90 chaperone cycle for steroid hormone receptors (SHR)
- Attenuation phase
- HSF1-dependent transactivation
- Lysosome Vesicle Biogenesis
- Golgi Associated Vesicle Biogenesis
- CHL1 interactions
- AUF1 (hnRNP D0) binds and destabilizes mRNA
- Interleukin-4 and Interleukin-13 signaling
- Neutrophil degranulation
- mRNA Splicing - Major Pathway
- Clathrin-mediated endocytosis
- Protein methylation
- GABA synthesis, release, reuptake and degradation
- Lipophagy
- Chaperone Mediated Autophagy
- Late endosomal microautophagy
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- Dasatinib
- (2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
- Copper
- Artenimol
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