SDHB - Wiki-MPM

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	RPL11	ribosomal protein L11	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	(S)-3-phenyllactic acid Anisomycin Puromycin	Diamond-Blackfan anemia (DBA)
Novel	FLOT1	flotillin 1	RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Synaptic adhesion-like molecules
Novel	MFAP2	microfibril associated protein 2	Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres
Novel	RAP1GAP	RAP1 GTPase activating protein	Rap1 signalling RET signaling
Novel	SLC9A1	solute carrier family 9 member A1	Hyaluronan uptake and degradation Sodium/Proton exchangers	Amiloride Homoserine Lactone Cariporide
Novel	CA6	carbonic anhydrase 6	Reversible hydration of carbon dioxide	Benzthiazide Cyclothiazide Zonisamide Mafenide Ellagic acid
Novel	STMN1	stathmin 1	Nuclear signaling by ERBB4
Novel	SLC45A1	solute carrier family 45 member 1
Novel	TARBP1	TAR (HIV-1) RNA binding protein 1
	PIK3R5	phosphoinositide-3-kinase regulatory subunit 5	GPVI-mediated activation cascade Synthesis of PIPs at the plasma membrane G beta:gamma signalling through PI3Kgamma Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
	ABCA1	ATP binding cassette subfamily A member 1	PPARA activates gene expression Defective ABCA1 causes TGD HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	ATP Glyburide Probucol	Tangier disease Hypoalphalipoproteinemia
	XRN1	5'-3' exoribonuclease 1	mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
	SPRY2	sprouty RTK signaling antagonist 2	Spry regulation of FGF signaling EGFR downregulation
	CARTPT	CART prepropeptide		Amphetamine
	GEM	GTP binding protein overexpressed in skeletal muscle

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