Search Results for: PTEN

365 interactions involving PTEN - phosphatase and tensin homolog found:

Sort by: Symbol Number of Pathways Number of Drugs Number of Diseases
Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
KDM1A lysine demethylase 1A
  • HDACs deacetylate histones
  • HDMs demethylate histones
  • Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
  • Regulation of PTEN gene transcription
  • Estrogen-dependent gene expression
  • NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
  • Potential therapeutics for SARS
  • Factors involved in megakaryocyte development and platelet production
KPNB1 karyopherin subunit beta 1
  • ISG15 antiviral mechanism
  • Apoptosis induced DNA fragmentation
  • Regulation of cholesterol biosynthesis by SREBP (SREBF)
  • Transport of Ribonucleoproteins into the Host Nucleus
  • NS1 Mediated Effects on Host Pathways
  • Nuclear import of Rev protein
  • Nuclear import of Rev protein
  • Initiation of Nuclear Envelope (NE) Reformation
  • Neutrophil degranulation
  • Postmitotic nuclear pore complex (NPC) reformation
  • Inhibition of nitric oxide production
LATS1 large tumor suppressor kinase 1
  • Signaling by Hippo
  • Fostamatinib
LGALS1 galectin 1
  • Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
  • Post-translational protein phosphorylation
  • Mercaptoethanol
  • Thiodigalactoside
  • 1,4-Dithiothreitol
  • Artenimol
LIMA1 LIM domain and actin binding 1
LINC00839 long intergenic non-protein coding RNA 839
LINC01198 long intergenic non-protein coding RNA 1198
LINC02023 long intergenic non-protein coding RNA 2023
LMNB1 lamin B1
  • Meiotic synapsis
  • Formation of Senescence-Associated Heterochromatin Foci (SAHF)
  • Nuclear Envelope Breakdown
  • Initiation of Nuclear Envelope (NE) Reformation
  • Breakdown of the nuclear lamina
  • Depolymerisation of the Nuclear Lamina
  • Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
  • Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
LRPPRC leucine rich pentatricopeptide repeat containing
  • TP53 Regulates Metabolic Genes
  • Respiratory electron transport
LTV1 LTV1 ribosome biogenesis factor
  • Major pathway of rRNA processing in the nucleolus and cytosol
MAGED2 MAGE family member D2
  • Platelet degranulation
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
  • Nephrin family interactions
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3
MAP2K3 mitogen-activated protein kinase kinase 3
  • Oxidative Stress Induced Senescence
  • activated TAK1 mediates p38 MAPK activation
  • Fostamatinib
MAST1 microtubule associated serine/threonine kinase 1
  • Fostamatinib
MAST2 microtubule associated serine/threonine kinase 2
MAST3 microtubule associated serine/threonine kinase 3
MATR3 matrin 3
  • Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM)
MCM2 minichromosome maintenance complex component 2
  • Activation of ATR in response to replication stress
  • Unwinding of DNA
  • Assembly of the pre-replicative complex
  • Orc1 removal from chromatin
  • Activation of the pre-replicative complex
  • Switching of origins to a post-replicative state

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