PTEN - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Associated Diseases Hide
DAP3	death associated protein 3	Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination
DAXX	death domain associated protein	SUMOylation of transcription cofactors Regulation of TP53 Degradation HCMV Early Events Inhibition of DNA recombination at telomere Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations
DBN1	drebrin 1
DCAF11	DDB1 and CUL4 associated factor 11	Neddylation
DCAF13	DDB1 and CUL4 associated factor 13	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol Neddylation
DDB1	damage specific DNA binding protein 1	Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation	Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
DDOST	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	SRP-dependent cotranslational protein targeting to membrane Asparagine N-linked glycosylation Neutrophil degranulation Advanced glycosylation endproduct receptor signaling Maturation of spike protein
DDX1	DEAD-box helicase 1	tRNA processing in the nucleus
DDX21	DExD-box helicase 21	B-WICH complex positively regulates rRNA expression Major pathway of rRNA processing in the nucleolus and cytosol
DDX24	DEAD-box helicase 24
DDX47	DEAD-box helicase 47	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
DDX50	DExD-box helicase 50
DHX15	DEAH-box helicase 15	mRNA Splicing - Major Pathway
DHX9	DExH-box helicase 9	RIP-mediated NFkB activation via ZBP1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production mRNA Splicing - Major Pathway
DLC1	DLC1 Rho GTPase activating protein	Rho GTPase cycle
DLG1	discs large MAGUK scaffold protein 1	Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
DNAJA1	DnaJ heat shock protein family (Hsp40) member A1	HSP90 chaperone cycle for steroid hormone receptors (SHR)
DNAJA2	DnaJ heat shock protein family (Hsp40) member A2	HSP90 chaperone cycle for steroid hormone receptors (SHR)
DNAJA3	DnaJ heat shock protein family (Hsp40) member A3
DNAJB6	DnaJ heat shock protein family (Hsp40) member B6	Regulation of HSF1-mediated heat shock response

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