LYN - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
SPHK1	sphingosine kinase 1	Sphingolipid de novo biosynthesis Association of TriC/CCT with target proteins during biosynthesis VEGFR2 mediated cell proliferation Extra-nuclear estrogen signaling
SPHK2	sphingosine kinase 2	Sphingolipid de novo biosynthesis	Opaganib
SRC	SRC proto-oncogene, non-receptor tyrosine kinase	Signaling by ERBB2 Nuclear signaling by ERBB4 Downregulation of ERBB4 signaling PIP3 activates AKT signaling GAB1 signalosome Downstream signal transduction Constitutive Signaling by Aberrant PI3K in Cancer Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events DCC mediated attractive signaling DCC mediated attractive signaling Netrin mediated repulsion signals Regulation of commissural axon pathfinding by SLIT and ROBO RAF activation MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates PTK2 signaling InlA-mediated entry of Listeria monocytogenes into host cells Regulation of RUNX1 Expression and Activity RUNX2 regulates osteoblast differentiation Regulation of RUNX3 expression and activity Extra-nuclear estrogen signaling Activated NTRK2 signals through FYN Activated NTRK3 signals through PI3K Activated NTRK3 signals through PI3K Long-term potentiation Signaling downstream of RAS mutants Signaling by RAF1 mutants	Dasatinib RU84687 RU79256 N6-Benzyl Adenosine-5'-Diphosphate RU85493 RU78262 Phosphonotyrosine Malonic acid RU83876 RU90395 RU79072 RU78783 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine PASBN 2-[4-[(Z)-2-Acetamido-3-oxo-3-[[(3S)-2-oxo-1-[(4-phenylphenyl)methyl]azepan-3-yl]amino]prop-1-enyl]-2-formylphenyl]acetic acid PAS219 DPI59 RU82197 Phenylphosphate RU78300 RU79073 RU82209 ISO24 RU85053 RU78299 Oxalic Acid RU78191 Citric acid Paratoulene phosphate 4-[(4-METHYL-1-PIPERAZINYL)METHYL]-N-[3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]AMINO]PHENYL]-BENZAMIDE Purvalanol A XL228 Tirbanibulin Bosutinib 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-phenylurea 3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL PD-168393 [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl}amino)phenyl]acetonitrile PP-121 1-cyclobutyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 1-(1-methylethyl)-3-quinolin-6-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 2-(4-CARCOXY-5-ISOPROPYLTHIAZOLYL)BENZOPIPERIDINE N-(4-PHENYLAMINO-QUINAZOLIN-6-YL)-ACRYLAMIDE (2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide Ponatinib Nintedanib Fostamatinib
STAT3	signal transducer and activator of transcription 3	Interleukin-6 signaling BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction Signalling to STAT3 Senescence-Associated Secretory Phenotype (SASP) Signaling by Leptin POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Association of TriC/CCT with target proteins during biosynthesis Transcriptional regulation of pluripotent stem cells Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling PTK6 Activates STAT3 PTK6 Activates STAT3 Interleukin-20 family signaling MET activates STAT3 MET activates STAT3 Interleukin-15 signaling Interleukin-35 Signalling Interleukin-9 signaling Interleukin-37 signaling Interleukin-23 signaling Interleukin-23 signaling Interleukin-27 signaling Interleukin-21 signaling Transcriptional regulation of granulopoiesis Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Growth hormone receptor signaling	ENMD-1198	Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) Oral cancer
SYK	spleen associated tyrosine kinase	GPVI-mediated activation cascade GPVI-mediated activation cascade FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis DAP12 signaling Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Integrin signaling CLEC7A (Dectin-1) signaling Dectin-2 family Dectin-2 family Interleukin-2 signaling Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis FLT3 signaling through SRC family kinases Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Staurosporine N-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-carboxamide Tamatinib 2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide Ellagic acid Fostamatinib
TEC	tec protein tyrosine kinase	Signaling by SCF-KIT FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Interleukin-3, Interleukin-5 and GM-CSF signaling	Fostamatinib Zanubrutinib
TNF	tumor necrosis factor	Transcriptional regulation of white adipocyte differentiation TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR1-mediated ceramide production TNFR2 non-canonical NF-kB pathway Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling TNF signaling	Etanercept Adalimumab Infliximab Chloroquine Epinephrine Pseudoephedrine Thalidomide Glucosamine Clenbuterol Pranlukast Amrinone Afelimomab YSIL6 SD118 PN0621 OMS-103HP Talmapimod VX-702 Atiprimod CRx-139 CYT007-TNFQb Andrographolide Ethyl pyruvate AME-527 PR-104 Plinabulin Dexanabinol Onercept Golimumab Certolizumab pegol Pomalidomide Polaprezinc Foreskin fibroblast (neonatal) Foreskin keratinocyte (neonatal) Bryostatin 1 Binimetinib Dilmapimod Glycyrrhizic acid	Graft-versus-host disease Asthma Allograft rejection Systemic lupus erythematosus
TRAT1	T cell receptor associated transmembrane adaptor 1	PIP3 activates AKT signaling Downstream TCR signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
TRIM28	tripartite motif containing 28	Generic Transcription Pathway SUMOylation of transcription cofactors HCMV Early Events
TRIM55	tripartite motif containing 55
TRIM63	tripartite motif containing 63	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Antigen processing: Ubiquitination & Proteasome degradation
TRIP10	thyroid hormone receptor interactor 10	Rho GTPase cycle Clathrin-mediated endocytosis
TRPV4	transient receptor potential cation channel subfamily V member 4	TRP channels	Cannabidiol Butamben Medical Cannabis Nabiximols	Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD) TRPV4-related skeletal dysplasias, including: Autosomal dominant brachyolmia; Spondylometaphyseal dysplasia, Kozlowski type (SMDK); Metatropic dysplasia; Spondyloepiphyseal dysplasia, Maroteaux type ; Parastremmatic dysplasia TRPV4-related peripheral neuropathies, including: Congenital distal spinal muscular atrophy (CDSMA); Scapuloperoneal spinal muscle atrophy (SPSMA); Hereditary motor and sensory neuropathy type IIC (HMSN IIC) Distal hereditary motor neuropathies (dHMN)
TYK2	tyrosine kinase 2	Interleukin-6 signaling Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Other interleukin signaling Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions Interleukin-20 family signaling Interleukin-35 Signalling Interleukin-12 signaling Interleukin-12 signaling Interleukin-23 signaling Interleukin-23 signaling Interleukin-27 signaling Interleukin-27 signaling Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling Potential therapeutics for SARS	2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one Tofacitinib Fostamatinib	Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
UBB	ubiquitin B	Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Activation of NF-kappaB in B cells ISG15 antiviral mechanism Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants ER-Phagosome pathway Downregulation of ERBB4 signaling Spry regulation of FGF signaling Downregulation of ERBB2:ERBB3 signaling Budding and maturation of HIV virion NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment DDX58/IFIH1-mediated induction of interferon-alpha/beta APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Membrane binding and targetting of GAG proteins Assembly Of The HIV Virion APC-Cdc20 mediated degradation of Nek2A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G EGFR downregulation SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex TCF dependent signaling in response to WNT Downstream TCR signaling NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival Regulation of activated PAK-2p34 by proteasome mediated degradation NOTCH1 Intracellular Domain Regulates Transcription Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Separation of Sister Chromatids Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Regulation of PLK1 Activity at G2/M Transition Constitutive Signaling by NOTCH1 PEST Domain Mutants Stimuli-sensing channels Constitutive Signaling by NOTCH1 HD Domain Mutants FCERI mediated NF-kB activation Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus Regulation of innate immune responses to cytosolic DNA Glycogen synthesis Autodegradation of the E3 ubiquitin ligase COP1 Deactivation of the beta-catenin transactivating complex Myoclonic epilepsy of Lafora ABC-family proteins mediated transport Circadian Clock TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Regulation of FZD by ubiquitination PINK1-PRKN Mediated Mitophagy N-glycan trimming in the ER and Calnexin/Calreticulin cycle Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Hedgehog 'on' state Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway Negative regulation of MAPK pathway Regulation of necroptotic cell death NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAP3K8 (TPL2)-dependent MAPK1/3 activation HDR through Homologous Recombination (HRR) MAPK6/MAPK4 signaling UCH proteinases UCH proteinases Josephin domain DUBs Ub-specific processing proteases Ovarian tumor domain proteases Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Processing of DNA double-strand break ends DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation Negative regulation of MET activity CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 Cyclin D associated events in G1 G2/M Checkpoints Stabilization of p53 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Downregulation of ERBB2 signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins InlB-mediated entry of Listeria monocytogenes into host cell InlB-mediated entry of Listeria monocytogenes into host cell InlA-mediated entry of Listeria monocytogenes into host cells RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN localization Regulation of PTEN stability and activity Neddylation ER Quality Control Compartment (ERQC) Regulation of expression of SLITs and ROBOs Regulation of expression of SLITs and ROBOs NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus TICAM1-dependent activation of IRF3/IRF7 TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling Peroxisomal protein import Peroxisomal protein import Regulation of signaling by CBL Endosomal Sorting Complex Required For Transport (ESCRT) Iron uptake and transport Negative regulators of DDX58/IFIH1 signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Negative regulation of NOTCH4 signaling Chaperone Mediated Autophagy Late endosomal microautophagy Prevention of phagosomal-lysosomal fusion Modulation by Mtb of host immune system Alpha-protein kinase 1 signaling pathway Aggrephagy Aggrephagy RAS processing Pexophagy Maturation of protein E Maturation of protein E Negative regulation of FLT3 FLT3 signaling by CBL mutants TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation	(4s)-5-Fluoro-L-Leucine
UHRF2	ubiquitin like with PHD and ring finger domains 2	SUMOylation of transcription cofactors
UNC119	unc-119 lipid binding chaperone

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