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APBA3 |
amyloid beta precursor protein binding family A member 3 |
- Neurexins and neuroligins
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APBB1 |
amyloid beta precursor protein binding family B member 1 |
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
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APBB3 |
amyloid beta precursor protein binding family B member 3 |
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APP |
amyloid beta precursor protein |
- Platelet degranulation
- ECM proteoglycans
- Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
- G alpha (q) signalling events
- G alpha (i) signalling events
- Lysosome Vesicle Biogenesis
- Formyl peptide receptors bind formyl peptides and many other ligands
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- The NLRP3 inflammasome
- Advanced glycosylation endproduct receptor signaling
- Advanced glycosylation endproduct receptor signaling
- Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
- Post-translational protein phosphorylation
- TRAF6 mediated NF-kB activation
- Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
- Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
- Purinergic signaling in leishmaniasis infection
- Amyloid fiber formation
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- Deferoxamine
- Aluminium
- Zinc
- L-methionine (R)-S-oxide
- Resveratrol
- Tromethamine
- Phenserine
- Tetrathiomolybdate
- CAD106
- Mito-4509
- Edonerpic
- Dimercaprol
- Copper
- Florbetaben (18F)
- Florbetapir (18F)
- Flutemetamol (18F)
- Zinc acetate
- Aluminium phosphate
- Aluminum acetate
- Zinc chloride
- Zinc sulfate, unspecified form
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APPL1 |
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 |
- Caspase activation via Dependence Receptors in the absence of ligand
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AR |
androgen receptor |
- HSP90 chaperone cycle for steroid hormone receptors (SHR)
- Nuclear Receptor transcription pathway
- SUMOylation of intracellular receptors
- Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
- Ub-specific processing proteases
- RUNX2 regulates osteoblast differentiation
- RUNX2 regulates osteoblast differentiation
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- Diethylstilbestrol
- Levonorgestrel
- Progesterone
- Spironolactone
- Flutamide
- Oxandrolone
- Fluphenazine
- Testosterone
- Mitotane
- Estrone
- Nilutamide
- Tamoxifen
- Norethisterone
- Drostanolone
- Norgestimate
- Nandrolone phenpropionate
- Ketoconazole
- Acetophenazine
- Bicalutamide
- Fluoxymesterone
- Drospirenone
- Danazol
- Testosterone propionate
- Oxybenzone
- 1-Testosterone
- Boldenone
- Calusterone
- Periciazine
- Prasterone
- Flufenamic acid
- Stanolone
- (R)-Bicalutamide
- Metribolone
- (3AALPHA,4ALPHA,7ALPHA,7AALPHA)- 3A,4,7,7A-TETRAHYDRO-2-(4-NITRO-1-NAPHTHALENYL)-4,7-ETHANO-1H-ISOINDOLE-1,3(2H)-DIONE
- Cyproterone acetate
- LGD2941
- Dimethylcurcumin
- Oxymetholone
- Methyltestosterone
- Norelgestromin
- Stanozolol
- Tetrahydrogestrinone
- (2S)-N-(4-cyano-3-iodophenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide
- BMS-564929
- S-23
- phenoxy)propyl]amino}-2-(trifluoromethyl)benzonitrile
- (2S)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-3-(pentafluorophenoxy)propanamide
- Andarine
- (R)-3-BROMO-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE
- (5S,8R,9S,10S,13R,14S,17S)-13-{2-[(3,5-DIFLUOROBENZYL)OXY]ETHYL}-17-HYDROXY-10-METHYLHEXADECAHYDRO-3H-CYCLOPENTA[A]PHENANTHREN-3-ONE
- S-3-(4-FLUOROPHENOXY)-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE
- 1-TERT-BUTYL-3-(2,5-DIMETHYLBENZYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE
- 4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOL-2(3H)-YL]-1-NAPHTHONITRILE
- 2-chloro-4-{[(1R,3Z,7S,7aS)-7-hydroxy-1-(trifluoromethyl)tetrahydro-1H-pyrrolo[1,2-c][1,3]oxazol-3-ylidene]amino}-3-methylbenzonitrile
- LGD-2226
- 3-[(4-AMINO-1-TERT-BUTYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL)METHYL]PHENOL
- Triclosan
- Nandrolone decanoate
- Ulipristal
- Enzalutamide
- Eugenol
- Dienogest
- Norethynodrel
- Norgestrel
- Homosalate
- Enzacamene
- Mibolerone
- Phenothiazine
- Gestrinone
- Apalutamide
- Clascoterone
- Darolutamide
- Esculin
- Ligandrol
- Testosterone cypionate
- Testosterone enanthate
- Testosterone undecanoate
- Stanolone acetate
- Segesterone acetate
- Boldenone undecylenate
- Echinacoside
- Ketodarolutamide
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- 46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS)
- 46,XY disorders of sex development (Other), including: Persistent Mullerian duct syndrome; Hypospadias; Cryptorchidism
- Prostate cancer
- Spinal and bulbar muscular atrophy (SBMA); Kennedy's disease
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AREG |
amphiregulin |
- PIP3 activates AKT signaling
- Signaling by EGFR
- GRB2 events in EGFR signaling
- GAB1 signalosome
- SHC1 events in EGFR signaling
- EGFR downregulation
- COPII-mediated vesicle transport
- EGFR interacts with phospholipase C-gamma
- Constitutive Signaling by Aberrant PI3K in Cancer
- Inhibition of Signaling by Overexpressed EGFR
- RAF/MAP kinase cascade
- Cargo concentration in the ER
- PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- Extra-nuclear estrogen signaling
- Estrogen-dependent nuclear events downstream of ESR-membrane signaling
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ARF4 |
ADP ribosylation factor 4 |
- VxPx cargo-targeting to cilium
- VxPx cargo-targeting to cilium
- COPI-mediated anterograde transport
- COPI-dependent Golgi-to-ER retrograde traffic
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ARHGEF12 |
Rho guanine nucleotide exchange factor 12 |
- NRAGE signals death through JNK
- Rho GTPase cycle
- G alpha (12/13) signalling events
- Sema4D induced cell migration and growth-cone collapse
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ARHGEF7 |
Rho guanine nucleotide exchange factor 7 |
- EGFR downregulation
- NRAGE signals death through JNK
- Rho GTPase cycle
- Ephrin signaling
- G alpha (12/13) signalling events
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ARRB2 |
arrestin beta 2 |
- Activated NOTCH1 Transmits Signal to the Nucleus
- G alpha (s) signalling events
- Thrombin signalling through proteinase activated receptors (PARs)
- WNT5A-dependent internalization of FZD4
- Activation of SMO
- Activation of SMO
- MAP2K and MAPK activation
- Ub-specific processing proteases
- Signaling by moderate kinase activity BRAF mutants
- Signaling by high-kinase activity BRAF mutants
- Signaling by BRAF and RAF fusions
- Paradoxical activation of RAF signaling by kinase inactive BRAF
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- Signaling downstream of RAS mutants
- Signaling by RAF1 mutants
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ATIC |
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase |
- Purine ribonucleoside monophosphate biosynthesis
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- Tetrahydrofolic acid
- Methotrexate
- Pemetrexed
- AICA ribonucleotide
- Guanosine-5'-Monophosphate
- 5-monophosphate-9-beta-D-ribofuranosyl xanthine
- Acid yellow 54 free acid
- N-[4-([(2-Amino-4-oxo-1,4-dihydropyrido[3,2-d]pyrimidin-6-yl)methyl]{(2E)-3-[4-carbamoyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazol-5-yl]-2-propenoyl}amino)benzoyl]-L-glutamic acid
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- AICA-ribosiduria; ATIC deficiency
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ATP1A1 |
ATPase Na+/K+ transporting subunit alpha 1 |
- Ion homeostasis
- Ion transport by P-type ATPases
- Potential therapeutics for SARS
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- Digoxin
- Acetyldigitoxin
- Hydroflumethiazide
- Etacrynic acid
- Trichlormethiazide
- Deslanoside
- Ouabain
- Diazoxide
- Bretylium
- Ciclopirox
- Bepridil
- Potassium cation
- Aluminium
- Magnesium cation
- Digitoxin
- Almitrine
- Istaroxime
- Magnesium acetate
- Potassium acetate
- Potassium sulfate
- Potassium
- Magnesium levulinate
- Magnesium lactate
- Aluminium phosphate
- Aluminum acetate
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ATP1B1 |
ATPase Na+/K+ transporting subunit beta 1 |
- Basigin interactions
- Ion homeostasis
- Ion transport by P-type ATPases
- Potential therapeutics for SARS
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ATP5F1C |
ATP synthase F1 subunit gamma |
- Formation of ATP by chemiosmotic coupling
- Cristae formation
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- Quercetin
- 1-ACETYL-2-CARBOXYPIPERIDINE
- AUROVERTIN B
- Piceatannol
- N1-(2-AMINO-4-METHYLPENTYL)OCTAHYDRO-PYRROLO[1,2-A] PYRIMIDINE
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AXL |
AXL receptor tyrosine kinase |
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- Fostamatinib
- Gilteritinib
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B4GALT1 |
beta-1,4-galactosyltransferase 1 |
- Pre-NOTCH Processing in Golgi
- Keratan sulfate biosynthesis
- Interaction With Cumulus Cells And The Zona Pellucida
- Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
- Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
- Lactose synthesis
- Neutrophil degranulation
- N-Glycan antennae elongation
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- N-Acetylglucosamine
- 6-Aminohexyl-uridine-C1,5'-diphosphate
- 4)-N-acetyl-beta-D-glucosamine
- Galactose-uridine-5'-diphosphate
- Uridine monophosphate
- 2-(N-morpholino)ethanesulfonic acid
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- Congenital disorders of glycosylation (CDG) type II
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BAIAP2 |
BAR/IMD domain containing adaptor protein 2 |
- Regulation of actin dynamics for phagocytic cup formation
- Regulation of actin dynamics for phagocytic cup formation
- VEGFA-VEGFR2 Pathway
- RHO GTPases Activate WASPs and WAVEs
- RHO GTPases Activate WASPs and WAVEs
- FCGR3A-mediated phagocytosis
- FCGR3A-mediated phagocytosis
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BCAR3 |
BCAR3 adaptor protein, NSP family member |
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BLK |
BLK proto-oncogene, Src family tyrosine kinase |
- RUNX1 regulates transcription of genes involved in BCR signaling
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
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- Fostamatinib
- Zanubrutinib
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- Maturity onset diabetes of the young (MODY)
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