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SLC25A6 |
solute carrier family 25 member 6 |
- Mitochondrial protein import
- Mitochondrial protein import
- Influenza Virus Induced Apoptosis
- Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
- Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
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- Clodronic acid
- Etidronic acid
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ATM |
ATM serine/threonine kinase |
- DNA Damage/Telomere Stress Induced Senescence
- Regulation of HSF1-mediated heat shock response
- Autodegradation of the E3 ubiquitin ligase COP1
- HDR through Single Strand Annealing (SSA)
- HDR through Homologous Recombination (HRR)
- Sensing of DNA Double Strand Breaks
- Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Resolution of D-loop Structures through Holliday Junction Intermediates
- Nonhomologous End-Joining (NHEJ)
- Homologous DNA Pairing and Strand Exchange
- Processing of DNA double-strand break ends
- Presynaptic phase of homologous DNA pairing and strand exchange
- TP53 Regulates Transcription of DNA Repair Genes
- TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
- TP53 Regulates Transcription of Caspase Activators and Caspases
- Regulation of TP53 Activity through Phosphorylation
- Regulation of TP53 Degradation
- Regulation of TP53 Activity through Methylation
- G2/M DNA damage checkpoint
- Stabilization of p53
- Meiotic recombination
- Pexophagy
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- Ataxia telangiectasia (AT); Louis-Bar syndrome; Boder-Sedgwick syndrome
- DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
- Ataxia with ocular apraxia (AOA), including: Ataxia telangiectasia (AT); Ataxia telangiectasia like disorder (ATLD); Ataxia oculomotor apraxia type 1 (AOA1); Ataxia oculomotor apraxia type 2 (AOA2)
- Chronic lymphocytic leukemia (CLL)
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CDKN1A |
cyclin dependent kinase inhibitor 1A |
- SCF(Skp2)-mediated degradation of p27/p21
- AKT phosphorylates targets in the cytosol
- Senescence-Associated Secretory Phenotype (SASP)
- DNA Damage/Telomere Stress Induced Senescence
- Constitutive Signaling by AKT1 E17K in Cancer
- Interleukin-4 and Interleukin-13 signaling
- TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
- Cyclin E associated events during G1/S transition
- Cyclin D associated events in G1
- p53-Dependent G1 DNA Damage Response
- Cyclin A:Cdk2-associated events at S phase entry
- Transcriptional activation of cell cycle inhibitor p21
- The role of GTSE1 in G2/M progression after G2 checkpoint
- TFAP2 (AP-2) family regulates transcription of cell cycle factors
- Transcriptional regulation by RUNX2
- RUNX3 regulates CDKN1A transcription
- Transcriptional regulation of granulopoiesis
- FOXO-mediated transcription of cell cycle genes
- Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
- STAT5 activation downstream of FLT3 ITD mutants
- Signaling by FLT3 fusion proteins
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KLK7 |
kallikrein related peptidase 7 |
- Degradation of the extracellular matrix
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- L-alanyl-N-[(1S,2R)-1-benzyl-2-hydroxypropyl]-L-alaninamide
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MRC1 |
mannose receptor C-type 1 |
- Cross-presentation of soluble exogenous antigens (endosomes)
- Cross-presentation of soluble exogenous antigens (endosomes)
- Modulation by Mtb of host immune system
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- Technetium Tc-99m tilmanocept
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PLK3 |
polo like kinase 3 |
- TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
- Regulation of TP53 Activity through Phosphorylation
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PPP2R2A |
protein phosphatase 2 regulatory subunit Balpha |
- Initiation of Nuclear Envelope (NE) Reformation
- Cyclin D associated events in G1
- Cyclin A/B1/B2 associated events during G2/M transition
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
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- 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
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TSSK1B |
testis specific serine kinase 1B |
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AATF |
apoptosis antagonizing transcription factor |
- NRAGE signals death through JNK
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ARHGAP1 |
Rho GTPase activating protein 1 |
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ASF1A |
anti-silencing function 1A histone chaperone |
- Formation of Senescence-Associated Heterochromatin Foci (SAHF)
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ATR |
ATR serine/threonine kinase |
- Meiotic synapsis
- Activation of ATR in response to replication stress
- Regulation of HSF1-mediated heat shock response
- HDR through Single Strand Annealing (SSA)
- Processing of DNA double-strand break ends
- Presynaptic phase of homologous DNA pairing and strand exchange
- Fanconi Anemia Pathway
- TP53 Regulates Transcription of DNA Repair Genes
- Regulation of TP53 Activity through Phosphorylation
- G2/M DNA damage checkpoint
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- Alveolar rhabdomyosarcoma
- Seckel syndrome
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BAALC |
BAALC binder of MAP3K1 and KLF4 |
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BEX1 |
brain expressed X-linked 1 |
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BRCA1 |
BRCA1 DNA repair associated |
- Meiotic synapsis
- SUMOylation of DNA damage response and repair proteins
- HDR through Single Strand Annealing (SSA)
- HDR through Homologous Recombination (HRR)
- Metalloprotease DUBs
- Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Resolution of D-loop Structures through Holliday Junction Intermediates
- Nonhomologous End-Joining (NHEJ)
- Homologous DNA Pairing and Strand Exchange
- Processing of DNA double-strand break ends
- Presynaptic phase of homologous DNA pairing and strand exchange
- TP53 Regulates Transcription of DNA Repair Genes
- Regulation of TP53 Activity through Phosphorylation
- G2/M DNA damage checkpoint
- Transcriptional Regulation by E2F6
- Meiotic recombination
- Defective DNA double strand break response due to BRCA1 loss of function
- Defective DNA double strand break response due to BARD1 loss of function
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- Breast cancer
- Ovarian cancer
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BRCA2 |
BRCA2 DNA repair associated |
- HDR through Homologous Recombination (HRR)
- Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
- Resolution of D-loop Structures through Holliday Junction Intermediates
- Homologous DNA Pairing and Strand Exchange
- Presynaptic phase of homologous DNA pairing and strand exchange
- Meiotic recombination
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- Fanconi anemia
- Pancreatic cancer
- Breast cancer
- Ovarian cancer
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CDC25A |
cell division cycle 25A |
- Transcription of E2F targets under negative control by DREAM complex
- Polo-like kinase mediated events
- Activation of ATR in response to replication stress
- Ub-specific processing proteases
- Cyclin E associated events during G1/S transition
- Cyclin A/B1/B2 associated events during G2/M transition
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- Cyclin A:Cdk2-associated events at S phase entry
- Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
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CDC25C |
cell division cycle 25C |
- Polo-like kinase mediated events
- Activation of ATR in response to replication stress
- RHO GTPases activate PKNs
- TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
- TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
- Cyclin A/B1/B2 associated events during G2/M transition
- Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
- Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
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CDH13 |
cadherin 13 |
- Adherens junctions interactions
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CDK11B |
cyclin dependent kinase 11B |
- Recruitment of mitotic centrosome proteins and complexes
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