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NBN |
nibrin |
- DNA Damage/Telomere Stress Induced Senescence
- HDR through Single Strand Annealing (SSA)
- HDR through MMEJ (alt-NHEJ)
- HDR through Homologous Recombination (HRR)
- Sensing of DNA Double Strand Breaks
- Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Resolution of D-loop Structures through Holliday Junction Intermediates
- Nonhomologous End-Joining (NHEJ)
- Homologous DNA Pairing and Strand Exchange
- Processing of DNA double-strand break ends
- Presynaptic phase of homologous DNA pairing and strand exchange
- Regulation of TP53 Activity through Phosphorylation
- G2/M DNA damage checkpoint
- Meiotic recombination
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- DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
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PPP2R2B |
protein phosphatase 2 regulatory subunit Bbeta |
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- Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
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ST14 |
ST14 transmembrane serine protease matriptase |
- Formation of the cornified envelope
- Formation of the cornified envelope
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- Urokinase
- Benzamidine
- Camostat
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- Ichthyosis with hypotrichosis
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AATF |
apoptosis antagonizing transcription factor |
- NRAGE signals death through JNK
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ARHGAP1 |
Rho GTPase activating protein 1 |
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ASF1A |
anti-silencing function 1A histone chaperone |
- Formation of Senescence-Associated Heterochromatin Foci (SAHF)
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BAALC |
BAALC binder of MAP3K1 and KLF4 |
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BEX1 |
brain expressed X-linked 1 |
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CCL5 |
C-C motif chemokine ligand 5 |
- Chemokine receptors bind chemokines
- G alpha (i) signalling events
- Interleukin-10 signaling
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- Heparin Disaccharide I-S
- Heparin Disaccharide Iii-S
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CDC25A |
cell division cycle 25A |
- Transcription of E2F targets under negative control by DREAM complex
- Polo-like kinase mediated events
- Activation of ATR in response to replication stress
- Ub-specific processing proteases
- Cyclin E associated events during G1/S transition
- Cyclin A/B1/B2 associated events during G2/M transition
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- Cyclin A:Cdk2-associated events at S phase entry
- Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
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CDC25C |
cell division cycle 25C |
- Polo-like kinase mediated events
- Activation of ATR in response to replication stress
- RHO GTPases activate PKNs
- TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
- TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
- Cyclin A/B1/B2 associated events during G2/M transition
- Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
- Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
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CDH13 |
cadherin 13 |
- Adherens junctions interactions
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CDK11B |
cyclin dependent kinase 11B |
- Recruitment of mitotic centrosome proteins and complexes
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DAPK3 |
death associated protein kinase 3 |
- Caspase activation via Dependence Receptors in the absence of ligand
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- 2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one
- 4-(6-{[(1R)-1-(hydroxymethyl)propyl]amino}imidazo[1,2-b]pyridazin-3-yl)benzoic acid
- (4R)-7,8-dichloro-1',9-dimethyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile
- Fostamatinib
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DBF4 |
DBF4 zinc finger |
- Activation of ATR in response to replication stress
- Activation of the pre-replicative complex
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DIRAS3 |
DIRAS family GTPase 3 |
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E2F1 |
E2F transcription factor 1 |
- Activation of NOXA and translocation to mitochondria
- Inhibition of replication initiation of damaged DNA by RB1/E2F1
- Transcription of E2F targets under negative control by DREAM complex
- Transcription of E2F targets under negative control by DREAM complex
- Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
- Activation of PUMA and translocation to mitochondria
- Pre-NOTCH Transcription and Translation
- Pre-NOTCH Transcription and Translation
- Oxidative Stress Induced Senescence
- Oncogene Induced Senescence
- TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
- CDC6 association with the ORC:origin complex
- G2 Phase
- Cyclin E associated events during G1/S transition
- G1/S-Specific Transcription
- G1/S-Specific Transcription
- Cyclin D associated events in G1
- Cyclin A:Cdk2-associated events at S phase entry
- Transcriptional Regulation by E2F6
- Transcriptional regulation of granulopoiesis
- Transcriptional regulation of granulopoiesis
- Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
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ELAVL1 |
ELAV like RNA binding protein 1 |
- HuR (ELAVL1) binds and stabilizes mRNA
- mRNA Splicing - Major Pathway
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ENO1 |
enolase 1 |
- Glycolysis
- Gluconeogenesis
- Manipulation of host energy metabolism
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- Zinc
- Copper
- Artenimol
- Zinc acetate
- Zinc chloride
- Zinc sulfate, unspecified form
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FHL3 |
four and a half LIM domains 3 |
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