ATXN1 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
NR4A1	nuclear receptor subfamily 4 group A member 1	AKT phosphorylates targets in the nucleus Nuclear Receptor transcription pathway Constitutive Signaling by AKT1 E17K in Cancer
NUDT21	nudix hydrolase 21	mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
NUMBL	NUMB like endocytic adaptor protein
NUTM2B	NUT family member 2B
OAZ1	ornithine decarboxylase antizyme 1	Regulation of ornithine decarboxylase (ODC)	Ornithine
OPCML	opioid binding protein/cell adhesion molecule like	Post-translational modification: synthesis of GPI-anchored proteins
OTX2	orthodenticle homeobox 2			Anophthalmia and microphthalmia (A/M) Septo-optic dysplasia
PANX2	pannexin 2	Electric Transmission Across Gap Junctions
PEPD	peptidase D
PHPT1	phosphohistidine phosphatase 1
PIAS1	protein inhibitor of activated STAT 1	SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins Formation of Incision Complex in GG-NER Regulation of IFNG signaling
PICALM	phosphatidylinositol binding clathrin assembly protein	Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
PIM2	Pim-2 proto-oncogene, serine/threonine kinase
PLA2G10	phospholipase A2 group X	Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA	Varespladib methyl Crotalus adamanteus antivenin Agkistrodon piscivorus antivenin
PLEKHB1	pleckstrin homology domain containing B1
PLEKHN1	pleckstrin homology domain containing N1
PML	PML nuclear body scaffold	SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Regulation of TP53 Activity through Acetylation Interferon gamma signaling Regulation of RUNX1 Expression and Activity Regulation of PTEN localization HCMV Early Events	Arsenic trioxide	Acute myeloid leukemia (AML)
POGZ	pogo transposable element derived with ZNF domain
POM121	POM121 transmembrane nucleoporin	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation
POMP	proteasome maturation protein			Keratosis linearis with ichthyosis congenita and sclerosing keratoderma; KLICK syndrome

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