Search Results for: AR

Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
POU5F1 POU class 5 homeobox 1
  • POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
  • POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
  • Transcriptional regulation of pluripotent stem cells
PRKG1 protein kinase cGMP-dependent 1
  • Ca2+ pathway
PRMT1 protein arginine methyltransferase 1
  • RMTs methylate histone arginines
  • TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
  • RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
  • Extra-nuclear estrogen signaling
  • Estrogen-dependent gene expression
  • S-adenosyl-L-homocysteine
PRPF6 pre-mRNA processing factor 6
  • mRNA Splicing - Major Pathway
  • mRNA Splicing - Minor Pathway
PSMC3IP PSMC3 interacting protein
  • Meiotic recombination
PTEN phosphatase and tensin homolog
  • Synthesis of PIPs at the plasma membrane
  • Synthesis of IP3 and IP4 in the cytosol
  • Negative regulation of the PI3K/AKT network
  • Downstream TCR signaling
  • TP53 Regulates Metabolic Genes
  • PTEN Loss of Function in Cancer
  • Ub-specific processing proteases
  • Ovarian tumor domain proteases
  • Regulation of PTEN mRNA translation
  • Regulation of PTEN localization
  • Regulation of PTEN stability and activity
  • Transcriptional Regulation by MECP2
  • Phosphatidylethanolamine
  • Vulvar cancer
  • Prostate cancer
  • Endometrial Cancer
  • Glioma
  • Small cell lung cancer
  • Breast cancer
  • Hepatocellular carcinoma
  • Malignant melanoma
PTK6 protein tyrosine kinase 6
  • SCF(Skp2)-mediated degradation of p27/p21
  • Cyclin D associated events in G1
  • ERBB2 Activates PTK6 Signaling
  • PTK6 Regulates Proteins Involved in RNA Processing
  • PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
  • PTK6 Regulates Cell Cycle
  • PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
  • PTK6 Down-Regulation
  • PTK6 Expression
  • PTK6 Activates STAT3
  • PTK6 promotes HIF1A stabilization
  • Vandetanib
  • Fostamatinib
  • Zanubrutinib
PTPN11 protein tyrosine phosphatase non-receptor type 11
  • Interleukin-6 signaling
  • PI3K Cascade
  • MAPK3 (ERK1) activation
  • MAPK1 (ERK2) activation
  • GPVI-mediated activation cascade
  • Prolactin receptor signaling
  • PIP3 activates AKT signaling
  • Spry regulation of FGF signaling
  • Signaling by SCF-KIT
  • GAB1 signalosome
  • Downstream signal transduction
  • PECAM1 interactions
  • Tie2 Signaling
  • Constitutive Signaling by Aberrant PI3K in Cancer
  • Signaling by Leptin
  • Costimulation by the CD28 family
  • CTLA4 inhibitory signaling
  • PD-1 signaling
  • Signal regulatory protein family interactions
  • Netrin mediated repulsion signals
  • Platelet sensitization by LDL
  • Interleukin-3, Interleukin-5 and GM-CSF signaling
  • Interleukin-3, Interleukin-5 and GM-CSF signaling
  • PI-3K cascade:FGFR1
  • FRS-mediated FGFR1 signaling
  • PI-3K cascade:FGFR2
  • FRS-mediated FGFR2 signaling
  • FRS-mediated FGFR3 signaling
  • PI-3K cascade:FGFR3
  • FRS-mediated FGFR4 signaling
  • PI-3K cascade:FGFR4
  • Negative regulation of FGFR1 signaling
  • Negative regulation of FGFR2 signaling
  • Negative regulation of FGFR3 signaling
  • Negative regulation of FGFR4 signaling
  • PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
  • Regulation of IFNG signaling
  • RET signaling
  • Interleukin-20 family signaling
  • MET activates PTPN11
  • Regulation of RUNX1 Expression and Activity
  • Interleukin-37 signaling
  • Activated NTRK2 signals through FRS2 and FRS3
  • Interferon alpha/beta signaling
  • Regulation of IFNA signaling
  • Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
  • FLT3 Signaling
  • STAT5 Activation
  • STAT5 activation downstream of FLT3 ITD mutants
  • Signaling by FLT3 ITD and TKD mutants
  • Dodecyltrimethylammonium
  • Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
  • Metachondromatosis
PXN paxillin
  • GAB1 signalosome
  • VEGFA-VEGFR2 Pathway
  • Smooth Muscle Contraction
  • Localization of the PINCH-ILK-PARVIN complex to focal adhesions
  • Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
  • PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
RAC3 Rac family small GTPase 3
  • Rho GTPase cycle
  • PCP/CE pathway
RACK1 receptor for activated C kinase 1
  • Regulation of TNFR1 signaling
  • TNFR1-induced NFkappaB signaling pathway
  • TNFR1-mediated ceramide production
  • Copper
RAD54L2 RAD54 like 2
RAD9A RAD9 checkpoint clamp component A
  • Activation of ATR in response to replication stress
  • HDR through Single Strand Annealing (SSA)
  • Processing of DNA double-strand break ends
  • Presynaptic phase of homologous DNA pairing and strand exchange
  • Regulation of TP53 Activity through Phosphorylation
  • G2/M DNA damage checkpoint
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
  • Stimuli-sensing channels
  • Rap1 signalling
  • GP1b-IX-V activation signalling
  • CD209 (DC-SIGN) signaling
  • RAF activation
  • MAP2K and MAPK activation
  • Negative feedback regulation of MAPK pathway
  • Negative regulation of MAPK pathway
  • Signaling by moderate kinase activity BRAF mutants
  • Signaling by high-kinase activity BRAF mutants
  • Signaling by BRAF and RAF fusions
  • Paradoxical activation of RAF signaling by kinase inactive BRAF
  • Signaling downstream of RAS mutants
  • Signaling by RAF1 mutants
  • Signaling by MRAS-complex mutants
  • Sorafenib
  • LErafAON
  • XL281
  • iCo-007
  • Cholecystokinin
  • Regorafenib
  • Dabrafenib
  • Fostamatinib
RAN RAN, member RAS oncogene family
  • Rev-mediated nuclear export of HIV RNA
  • Regulation of cholesterol biosynthesis by SREBP (SREBF)
  • NEP/NS2 Interacts with the Cellular Export Machinery
  • Nuclear import of Rev protein
  • MicroRNA (miRNA) biogenesis
  • Transcriptional regulation by small RNAs
  • tRNA processing in the nucleus
  • Postmitotic nuclear pore complex (NPC) reformation
  • Postmitotic nuclear pore complex (NPC) reformation
  • Guanosine-5'-Diphosphate
RANBP9 RAN binding protein 9
  • L1CAM interactions
  • RAF/MAP kinase cascade
  • MET activates RAS signaling
RASA1 RAS p21 protein activator 1
  • Downstream signal transduction
  • EPHB-mediated forward signaling
  • EPHB-mediated forward signaling
  • VEGFR2 mediated cell proliferation
  • Regulation of RAS by GAPs
  • PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
  • RASA1-related disorders, including: Parkes-Weber slndrome; Capillary malformation-arteriovenous malformation (CM-AVM); Arteriovenous fistula (AVF)
RB1 RB transcriptional corepressor 1
  • Inhibition of replication initiation of damaged DNA by RB1/E2F1
  • Inhibition of replication initiation of damaged DNA by RB1/E2F1
  • APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
  • Condensation of Prophase Chromosomes
  • Formation of Senescence-Associated Heterochromatin Foci (SAHF)
  • Oncogene Induced Senescence
  • Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
  • Cyclin E associated events during G1/S transition
  • Cyclin D associated events in G1
  • Cyclin A:Cdk2-associated events at S phase entry
  • RUNX2 regulates osteoblast differentiation
  • Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
  • Defective translocation of RB1 mutants to the nucleus
  • Replication of the SARS-CoV-1 genome
  • Aberrant regulation of mitotic exit in cancer due to RB1 defects
  • Replication of the SARS-CoV-2 genome
  • Insulin human
  • Insulin pork
  • Bladder cancer
  • Small cell lung cancer
  • Glioma
  • Osteosarcoma
  • Breast cancer
  • Esophageal cancer
  • Hepatocellular carcinoma
  • Chronic myeloid leukemia (CML)
RBAK RB associated KRAB zinc finger
RCHY1 ring finger and CHY zinc finger domain containing 1
  • Translesion Synthesis by POLH
  • Antigen processing: Ubiquitination & Proteasome degradation

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